Chou,Chia-Fu / Research Fellow


Contact Information



Chu, Michelle / 886-2-2789-8364

Research Interest

  • Biophysics, Biophotonics, Nanobiotechnology, Micro/nanofluidics, Liquid Crystals


(1) 國內學術研究獎項 2014-04 2013 科技部傑出研究獎 Outstanding Research Award of Ministry of Science and Technology


  • 2007- Adjunct Research Fellow, Genomics Research Center, Academia Sinica
  • 2006- Adjunct Research Fellow, Research Center for Applied Sciences, Academia Sinica
  • 2005-Adjunct Faculty, Harrington Department of Bioengineering, Arizona State University
  • 2003-2005Associate Professor & Principal Investigator, Co-Founder, Center for Applied NanoBioscience at Biodesign Institute, Arizona State University
  • 2001-2002Principal Staff Scientist, Micro-Technologies Research Lab, Motorola Labs
  • 2000-2001 Lead Scientist, Micro-Technologies Research Lab, Motorola Labs
  • 1997-2000Postdoctoral Research Fellow, Departments of Physics and Molecular Biology, Princeton University


Journal Papers

  • [1]     Lai Chih-Yu, Weng Jui-Hong, Shih Wei-Li, Chen Lin-Chi, Chou Chia-Fu, Wei Pei-Kuen, 2019, “Diffusion impedance modeling for interdigitated array electrodes by conformal mapping and cylindrical finite length approximation”, Electrochimica Acta, 320 134629. (SCI) (IF: 5.116; SCI ranking: 17.9%)

  • [2]     Pan Ming-Yang, Yang Deng-Kai, Lai Chih-Yu, Weng Jui-Hong, Lee Kuang-Li, Chen Lin-Chi, Chou Chia-Fu, Wei Pei-Kuen, 2019, “Spectral contrast imaging method for mapping transmission surface plasmon images in metallic nanostructures”, Biosensors and Bioelectronics, 142 111545. (SCI) (IF: 8.173; SCI ranking: 6.9%,2.5%,5%,7.1%,15.2%)

  • [3]     P. Teerapanich, M. Pugnière, C. Henriquet , Y. L. Lin , A. Naillona, P. Josepha, C. F. Chou, T. Leichle*, 2018, “Nanofluidic fluorescence microscopy with integrated concentration gradient generation for one-shot parallel kinetic assays”, SENSORS AND ACTUATORS B-CHEMICAL, 274, 338-342. (SCI) (IF: 5.401; SCI ranking: 7.9%,10.3%,3.4%)

  • [4]     D.K. Yang, C.F. Chou, L.C. Chen*, 2018, “Selection of Aptamers for AMACR Detection from the DNA Libraries with Different Primers”, RSC ADVANCES, 8, 19067. (SCI) (IF: 3.108; SCI ranking: 35.5%)

  • [5]     A. Rohani, B. J. Sanghavi, A. Salahi, K. T. Liao, C. F. Chou, N. S. Swami*, 2017, “Frequency-selective electrokinetic enrichment of biomolecules in physiological media based on electrical double-layer polarization”, NANOSCALE, 9, 12124-12131. (SCI) (IF: 7.367; SCI ranking: 8.4%,14.9%,8.8%,12.7%)

  • [6]     F. T. Chien, P. K. Lin, W. Chien, C. H. Hung, M. H. Yu, C. F. Chou, Y. L. Chen*, 2017, “Crowding-facilitated macromolecular transport in attractive micropost arrays”, SCIENTIFIC REPORTS, 7, 1340. (SCI) (IF: 4.259; SCI ranking: 15.6%)

  • [7]     P. Teerapanich, M. Pugnière, C. Henriquet , Y. L. Lin , C. F. Chou, T. Leichle*, 2017, “Nanofluidic Fluorescence Microscopy (NFM) for real-time monitoring of protein binding kinetics and affinity studies”, BIOSENSORS & BIOELECTRONICS, 88, 25-33. (SCI) (IF: 7.78; SCI ranking: 8.2%,5.6%,3.4%,2.6%,12.6%)

  • [8]     K. K. Sriram, S. Nayak, C.F. Chou*, A. Erbe*, 2017, “10-nm Deep, Sub-Nanoliter Fluidic Nanochannels on Germanium for Attenuated Total Reflection Infrared (ATR-IR) Spectroscopy”, ANALYST, 142, 273-278. (SCI) (IF: 3.885; SCI ranking: 15.8%)

  • [9]     R. Fernandez, B. Sanghavi, V. Farmehini, J. Chavez, J. Hagen, N. Kelley-Loughnane, C.F. Chou, N. Swami*, 2016, “Aptamer-functionalized graphene-gold nanocomposites for label-free detection of dielectrophoretic-enriched neuropeptide Y”, ELECTROCHEMISTRY COMMUNICATIONS, 72, 144–147. (SCI) (IF: 4.396; SCI ranking: 17.2%)

  • [10]     C. Sharma, A.K. Dinda, P.D. Potdar, C.F. Chou, N.C. Mishra *, 2016, “Fabrication and characterization of novel nanobiocomposite scaffold of chitosan–gelatin–alginate–hydroxyapatite for bone tissue engineering”, Materials Science & Engineering C-Materials for Biological Applications, 64, 416–427. (SCI) (IF: 4.164; SCI ranking: 27.3%)

  • [11]     J.P. Shen and C.F. Chou* , 2016, “Morphological Plasticity of Bacteria − Open Questions”, Biomicrofluidics, 10(3), 031501. (SCI) (IF: 2.535; SCI ranking: 25.8%,50.6%,46.2%,49.3%)

  • [12]     Y.L. Lin, Y.J. Huang, P. Teerapanich, T. Leichlé, C.F. Chou* , 2016, “Multiplexed immunosensing and kinetics monitoring in nanofluidic devices with highly enhanced target capture efficiency”, Biomicrofluidics, 10(3), 034114. (SCI) (IF: 2.535; SCI ranking: 25.8%,50.6%,46.2%,49.3%)

  • [13]     A. Rohani, W. Varhue, K.T. Liao, C.F. Chou, N.S. Swami* , 2016, “Nanoslit design for ion conductivity gradient enhanced dielectrophoresis for ultrafast biomarker enrichment in physiological media”, Biomicrofluidics, 10, 033109. (SCI) (IF: 2.535; SCI ranking: 25.8%,50.6%,46.2%,49.3%)

  • [14]     B.J. Sanghavi, J.A. Moore, J.L. Chávez, J.A. Hagen, N. Kelley-Loughnane, C.F. Chou, N.S. Swami, 2016, “Aptamer-functionalized nanoparticles for surface immobilization-free electrochemical detection of cortisol in a microfluidic device”, BIOSENSORS & BIOELECTRONICS, 78, 244–252. (SCI) (IF: 7.78; SCI ranking: 8.2%,5.6%,3.4%,2.6%,12.6%)

  • [15]     P. Spuul, P.Y. Chi, C. Billottet, C.F. Chou*, E. Genot* , 2016, “Microfluidic devices for the study of actin cytoskeleton in constricted environments: Evidence for podosome formation in endothelial cells exposed to a confined slit”, METHODS, 94, 65–74. (SCI) (IF: 3.802; SCI ranking: 30.7%,26.9%)

  • [16]     Y.H Su, P.C. Chiang, L.J. Cheng, C.H. Lee, N.S. Swami*, C.F. Chou* , 2015, “High aspect ratio nanoimprinted grooves of poly(lactic-co-glycolic acid) control the length and direction of retraction fibers during fibroblast cell division”, Biointerphases, 10, 041008. (SCI) (IF: 2.603; SCI ranking: 57.6%,45.2%)

  • [17]     B.J. Sanghavi, W. Varhue, A. Rohani, K.T. Liao, L. Bazydlo, C.F. Chou*, N. S. Swami* , 2015, “Ultrafast immunoassays by coupling dielectrophoretic biomarker enrichment on nanoslit molecular dam with electrochemical detection on graphene”, Lab Chip, 15, 4563-4570. (SCI) (IF: 6.045; SCI ranking: 7.7%,15.1%,20.7%)

  • [18]     T. Leichlé and C.F. Chou* , 2015, “Biofunctionalized Nanoslit Sensors for Wash-Free and Fast Real-Time Sensing with Spatiotemporally Resolved Kinetics”, Biomicrofluidics, 9, 034103. (SCI) (IF: 2.535; SCI ranking: 25.8%,50.6%,46.2%,49.3%)

  • [19]     C. F. Chou*, P. K. Wei, and Y. L. Chen , 2014, “Preface to Special Topic: Selected Papers from the Advances in Microfluidics and Nanofluidics 2014 Conference in Honor of Professor Hsueh-Chia Chang's 60th Birthday”, Biomicrofluidics, 8, 051901. (SCI) (IF: 2.571; SCI ranking: 54.3%,32.3%,43%,47.2%)

  • [20]     K. K. Sriram, C.L. Chang, U. R. Kumar, C.F. Chou*, 2014, “DNA Combing on Low-Pressure Oxygen Plasma Modified Polysilsesquioxane Substrates For Single-Molecule Studies”, Biomicrofluidics, 8, 052102. (SCI) (IF: 2.571; SCI ranking: 54.3%,32.3%,43%,47.2%)

  • [21]     J. P. Shen, C. F. Chou* , 2014, “Bacteria under the Physical Constraints of Periodic Micro-Nanofluidic Junctions Reveal Morphological Plasticity and Dynamic Shifting of Min Patterns”, Biomicrofluidics, 8, 041103 (Fast Track Article). (SCI) (IF: 2.571; SCI ranking: 54.3%,32.3%,43%,47.2%)

  • [22]     K.K. Sriram, J.W. Yeh, Y.L. Lin, Y.R. Chang, C.F. Chou*, 2014, “Direct Optical Mapping of Transcription Factor Binding Sites on Field-stretched λ-DNA in Nanofluidic Devices”, NUCLEIC ACIDS RESEARCH, 42, e85. (SCI) (IF: 11.561; SCI ranking: 3.4%)

  • [23]     B. Sanghavi, W. Varhue, J. Chávez, C.F. Chou, N. S. Swami* , 2014, “Electrokinetic preconcentration and detection of neuropeptides at patterned graphene-modified electrodes in a nanochannel”, ANALYTICAL CHEMISTRY, 86 (9), 4120–4125. (SCI) (IF: 6.042; SCI ranking: 4.9%)

  • [24]     C. Lin, E. H.-L. Chen, L. Y.-L. Lee, R. L. Hsu, F. Y. Luh, L. L. Yang, C. F. Chou, L. D. Huang, C. C. Lin, R. P.-Y. Chen*, 2014, “Comparison of the anti-amyloidogenic effect of O-mannosylation, O-galactosylation, and O-GalNAc glycosylation”, CARBOHYDRATE RESEARCH, 387, 46–53. (SCI) (IF: 2.074; SCI ranking: 49.1%,43.1%,70.6%)

  • [25]     S. Gautam, C. F. Chou, A. K. Dinda, P. D. Potdar, N. C. Mishra* , 2014, “Fabrication and Characterization of PCL/Gelatin/Chitosan Ternary Nanofibrous Composite Scaffold for Tissue Engineering Applications”, JOURNAL OF MATERIALS SCIENCE, 49, 1076–1089. (SCI) (IF: 2.993; SCI ranking: 29.5%)

  • [26]     L. Lesser-Rojas, P. Ebbinghaus, G. Vasan, M. L. Chu, A. Erbe*, C. F. Chou*, 2014, “Low-Copy Number Protein Detection by Electrode Nanogap-Enabled Dielectrophoretic Trapping forSurface-enhanced Raman Spectroscopy and Electronic Measurements”, NANO LETTERS, 14(5), 2242–2250. (SCI) (IF: 12.08; SCI ranking: 11.9%,10.9%,6.2%,8.8%,6.7%,7.5%)

  • [27]     S. Gautam, C. F. Chou, A. K. Dinda, P. D. Potdar, N. C. Mishra*, 2014, “Surface Modification of Nanofibrous Polycaprolactone/Gelatin Composite Scaffold by Collagen I Grafting for Skin Tissue Engineering”, Materials Science & Engineering C-Materials for Biological Applications, 34, 402–409. (SCI) (IF: 5.08; SCI ranking: 18.2%)

  • [28]     L. Lesser-Rojas, K. K. Sriram, K.T. Liao, S.C. Lai, P.C. Kuo, M.L. Chu, C.F. Chou*, 2014, “Tandem array of nanoelectronic readers embedded coplanar to a fluidic nanochannel for correlated single biopolymer analysis”, Biomicrofluidics, 8, 016501. (SCI) (IF: 2.571; SCI ranking: 54.3%,32.3%,43%,47.2%)

  • [29]     A. Taloni*, J. W. Yeh, C. F. Chou* , 2013, “Scaling Theory of Stretched DNA In Nanoslits”, MACROMOLECULES, 46 (19), 7989–8002. (SCI) (IF: 5.914; SCI ranking: 5.7%)

  • [30]     V. Chaurey, A. Rohani, Y.H. Su, K.T. Liao, C.F. Chou*, N.S. Swami* , 2013, “Scaling down constriction-based (electrodeless) dielectrophoresis devices for trapping nanoscale bio-particles in physiological media of high-conductivity”, ELECTROPHORESIS, 34, 1097–1104.. (SCI) (IF: 2.569; SCI ranking: 34.6%,44.3%)

  • [31]     V. Chaurey, F. Block, Y.H. Su, P.C. Chiang, E. Botchwey, C.F. Chou, N.S. Swami*, 2012, “Nanofiber size-dependent sensitivity of fibroblast directionality to the methodology for scaffold alignment”, Acta Biomaterialia, 8, 3982–3990. (SCI) (IF: 6.383; SCI ranking: 5.1%,9.1%)

  • [32]     Kuo-Tang Liao, Chia-Fu Chou*, 2012, “Nanoscale molecular traps and dams for ultrafast protein enrichment in high-conductivity buffers (Featured in JACS Spotlights)”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134 (21), 8742−8745. (SCI) (IF: 14.357; SCI ranking: 4.7%)

  • [33]     Jia-Wei Yeh, Alessandro Taloni, Yeng-Long Chen, Chia-Fu Chou*, 2012, “Entropy-driven single molecule tug-of-war of DNA at micro-nanofluidic interfaces (Research Highlighted by Nature)”, NANO LETTERS, 12 (3), 1597–1602. (SCI) (IF: 12.08; SCI ranking: 11.9%,10.9%,6.2%,8.8%,6.7%,7.5%)

  • [34]     T. Leïchlé, Y.L. Lin, P.C. Chiang, K.T. Liao, S.M. Hu, C.F. Chou* , 2012, “Biosensor-compatible encapsulation for pre-functionalized nanofluidic channels using asymmetric plasma treatment”, SENSORS AND ACTUATORS B-CHEMICAL, 161, 805–810. (SCI) (IF: 5.667; SCI ranking: 14.3%,3.3%,8.6%)

  • [35]     P.K. Lin, C.C. Hsieh, Y.L Chen*, C.F. Chou* , 2012, “Effects of Topology and Ionic Strength on Double-Stranded DNA Confined in Nanoslits”, MACROMOLECULES, 45(6), 2920–2927. (SCI) (IF: 5.914; SCI ranking: 5.7%)

  • [36]     V. Chaurey, C. Polanco, C.F. Chou*, N.S. Swami*, 2012, “Floating-electrode enhanced constriction dielectrophoresis for biomolecular trapping in media of high-conductivity”, Biomicrofluidics, 6, 012806. (SCI) (IF: 2.571; SCI ranking: 54.3%,32.3%,43%,47.2%)

  • [37]     V. Chaurey, K.T. Liao, C. Polanco, C.F. Chou*, N.S. Swami*, 2012, “Nano-constriction device for rapid protein pre-concentration through balance of electrokinetic forces”, ELECTROPHORESIS, 33, 1958-1966. (SCI) (IF: 2.569; SCI ranking: 34.6%,44.3%)

  • [38]     C.C. Wang, Y.C. Kao, P.Y. Chi, C.W. Huang, J.Y. Lin, C.F. Chou, J.Y. Cheng*, C.H. Lee, 2011, “Asymmetric cancer-cell filopodium growth induced by electric-fields in a microfluidic culture chip”, LAB ON A CHIP, 11, 695-699. (SCI) (IF: 5.995; SCI ranking: 6.2%,26.1%,18.7%,6.3%)

  • [39]     Y.L. Chen, P. K. Lin, C.F. Chou , 2010, “Generalized force-extension relation for worm-like chains in slit confinement”, MACROMOLECULES, 43, 10204–10207. (SCI) (IF: 5.914; SCI ranking: 5.7%)

  • [40]     V. Chaurey, P.C. Chiang, C. Polanco, Y.H. Su, C.F Chou*, N. Swami*, 2010, “Interplay of Electrical Forces for Alignment of Sub-100 nm Electrospun Nanofibers on Insulator Gap Collectors”, LANGMUIR, 26, 19022–19026. (SCI) (IF: 3.789; SCI ranking: 32.7%,21.4%,29.2%)

  • [41]     N. Swami, C. F. Chou*, V. Ramamurthy, V. Chaurey , 2009, “Enhancing DNA hybridization kinetics through constriction-based dielectrophoresis”, LAB ON A CHIP, 9, 3212. (SCI) (IF: 5.995; SCI ranking: 6.2%,26.1%,18.7%,6.3%)

  • [42]     J. Gu, R. Gupta, C.F. Chou, Q. Wei, F. Zenhausern, 2007, “A simple polysilsesquioxane sealing of nanofluidic channels below 10 nm at room temperature”, LAB ON A CHIP, 7, 1198. (SCI) (IF: 5.995; SCI ranking: 6.2%,26.1%,18.7%,6.3%)

  • [43]     N. Swami, C.F. Chou, R. Terbrueggen , 2005, “Two-potential electrochemical surface probe of DNA immobilization”, LANGMUIR, 21, 1937. (SCI) (IF: 3.789; SCI ranking: 32.7%,21.4%,29.2%)

  • [44]     L.J. Guo, X. Cheng, C.F. Chou* , 2004, “Fabrication of Size-Controllable Nanofluidic Channels by Nanoimprinting and Its Application for DNA Stretching”, NANO LETTERS, 4, 69-73. (SCI) (IF: 12.08; SCI ranking: 11.9%,10.9%,6.2%,8.8%,6.7%,7.5%)

  • [45]     C.F. Chou*, F. Zenhausern , 2003, “Electrodeless Dielectrophoresis for Micro Total Analysis Systems”, IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE, 22, 62-67.

  • [46]     C.Y. Chao, T.C. Pan, C.F. Chou, J.T. Ho , 2003, “Multiple Electron Diffraction and Two-Dimensional Crystalline Order in Liquid-Crystal Thin Films”, PHYSICAL REVIEW LETTERS, 91, 125504. (SCI) (IF: 8.839; SCI ranking: 7.7%)

  • [47]     D. Sadler, R. Changrani, P. Roberts, C.F. Chou, F. Zenhausern , 2003, “Thermal Management of BioMEMS: Temperature Control for Ceramic-based PCR and DNA Detection Devices”, IEEE TRANSACTIONS ON COMPONENTS AND PACKAGING TECHNOLOGIES, 26 (2), 309-316.

  • [48]     C.F. Chou*, R. Changrani, P. Roberts, D. Sadler, S. Lin, A. Mulholland, N. Swami, R. Terbrueggen, F. Zenhausern, 2002, “A Miniaturized Cyclic PCR Device-Modeling and Experiments”, MICROELECTRONIC ENGINEERING, 61/62, 921-925. (SCI) (IF: 2.02; SCI ranking: 69.6%,47.7%,45.7%,43.2%)

  • [49]     C.F. Chou, J.O. Tegenfeldt, O. Bakajin, S.S. Chan, E.C. Cox, N. Darnton, T.A.J. Duke, R.H. Austin , 2002, “Electrodeless Dielectrophoresis of Single and Double Stranded DNA”, BIOPHYSICAL JOURNAL, 83, 2170. (SCI) (IF: 3.495; SCI ranking: 25%)

  • [50]     J. O. Tegenfeldt, O. Bakajin, C. F. Chou, S. S. Chan, R. H. Austin, W. Fann, L. Liou, E. Chan, T. Duke, and E. C. Cox, 2001, “Near-Field Scanner for Moving Molecules”, PHYSICAL REVIEW LETTERS, 86, 1378-1381. (SCI) (IF: 8.839; SCI ranking: 7.7%)

  • [51]     O. Bakajin, T. A. J. Duke, J. Tegenfeldt, C. F. Chou, S. S. Chan, R. H. Austin and E. C. Cox , 2001, “Separation of 100 kilobase DNA molecules in 10 seconds”, ANALYTICAL CHEMISTRY, 73, 6053-6056. (SCI) (IF: 6.042; SCI ranking: 4.9%)

  • [52]     C.F. Chou, R.H. Austin, O. Bakajin, J.O. Tegenfeldt, J.A. Castelino, S.S. Chan, E.C. Cox, H.G. Craighead, N. Darton, T.A.J. Duke, J. Han, S.W. Turner , 2000, “Sorting Biomolecules with Microdevices”, Electrophoresis, 21, 81-90. (SCI) (IF: 2.569; SCI ranking: 34.6%,44.3%)

  • [53]     C.Y. Chao, T.C. Pan, C.F. Chou, and J.T. Ho , 2000, “Structural Characterization of Surface Hexatic Behavior in Free-Standing 4O.8 Liquid-Crystal Films”, PHYSICAL REVIEW E, 62 (2): R1485-R1488. (SCI) (IF: 2.284; SCI ranking: 12.7%,38.7%)

  • [54]     C.F. Chou, O. Bakajin, S.W. Turner, T. Duke, S.S. Chan, R.H. Austin, E.C. Cox, and H.G. Craighead , 1999, “Sorting by Diffusion: an Asymmetric Obstacle Course for Continuous Molecular Separation”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96, 13762-13765. (SCI) (IF: 9.504; SCI ranking: 7.8%)

  • [55]     O.B. Bakajin, T.A.J. Duke, C.F. Chou, S.S. Chan, R.H. Austin, and E.C. Cox , 1998, “Electrohydrodynamic Stretching of DNA in Confined Environments”, PHYSICAL REVIEW LETTERS, 80, 2737-2740. (SCI) (IF: 8.839; SCI ranking: 7.7%)

  • [56]     C.F. Chou*, A.J. Jin, S.W. Hui, C.C. Huang, and J.T. Ho , 1998, “Multiple-Step Melting in Two-Dimensional Hexatic Liquid-Crystal Films”, SCIENCE, 280, 1424-1426. (SCI) (IF: 41.058; SCI ranking: 3.1%)

  • [57]     M. Veum, C.C. Huang, C.F. Chou, and V. Surendranath , 1997, “Stability and Phase Transitions of Single-Molecular-Layer Free-Standing Liquid-Crystal Films”, PHYSICAL REVIEW E, 56, 2298-2301. (SCI) (IF: 2.284; SCI ranking: 12.7%,38.7%)

  • [58]     C.Y. Chao, S.W. Hui, J.E. Maclennan, C.F. Chou, and J.T. Ho , 1997, “Surface-Freezing Transitions and Novel Tilted Hexatic Phases in Smectic Liquid-Crystal Films”, PHYSICAL REVIEW LETTERS, 78, 2581-2584. (SCI) (IF: 8.839; SCI ranking: 7.7%)

  • [59]     C.Y. Chao, C.F. Chou, J.T. Ho, S.W. Hui, A.J. Jin, and C.C. Huang , 1996, “Nature of Layer-by-Layer Freezing in Free-Standing 4O.8 Films”, PHYSICAL REVIEW LETTERS, 77, 2750-2753. (SCI) (IF: 8.839; SCI ranking: 7.7%)

  • [60]     A.J. Jin, M. Veum, T. Stoebe, C.F. Chou, J.T. Ho, S.W. Hui, V. Surendranath, and C.C. Huang , 1996, “Nature of the Smectic-A–Hexatic-B–Crystal-B Transitions of One Liquid-Crystal Compound”, PHYSICAL REVIEW E, 53, 3639-3646. (SCI) (IF: 2.284; SCI ranking: 12.7%,38.7%)

  • [61]     C.F. Chou, J.T. Ho, S.W. Hui, and V. Surendranath , 1996, “Scaling of 6n-Fold Bond-Orientational Order Parameters in a Hexatic Liquid-Crystal Thin Film”, PHYSICAL REVIEW LETTERS, 76, 4556-4559. (SCI) (IF: 8.839; SCI ranking: 7.7%)

  • [62]     A.J. Jin, M. Veum, T. Stoebe, C.F. Chou, J.T. Ho, S.W. Hui, V. Surendranath, and C.C. Huang , 1995, “Calorimetric and Structural Characterization of Thin Liquid-Crystal Films Exhibiting the Smectic-A–Hexatic-B–Crystal-B Transitions”, PHYSICAL REVIEW LETTERS, 74, 4863-4866. (SCI) (IF: 8.839; SCI ranking: 7.7%)

Chapters in Books

  • [1]     Chi Pei-Yin, Spuul Pirjo, Tseng Fan-Gang, Genot Elisabeth*, Chou Chia-Fu*, Taloni Alessandro*, 2019, “Cell Migration in Microfluidic Devices: Invadosomes Formation in Confined Environments”, editor(s): Caterina A. M. La Porta and Stefano Zapperi, Advances in Experimental Medicine and Biology, pp. 79-103, Switzerland: Springer Nature Switzerland AG.


(1) 西元年:2012
研究人員(中):周家復、葉佳唯、Alessandro Taloni、陳彥龍
研究人員(英):CHOU, CHIA-FU, Jia-Wei Yeh, Alessandro Taloni, Yeng-Long Chen
研究成果名稱(英):Entropy-driven single molecule tug-of-war of DNA at micro-nanofluidic interfaces
簡要記述(英):Entropy-driven polymer dynamics at the nanoscale is fundamentally important in biological systems but the dependence of the entropic force on the nanoconfinement remains elusive. Here we established an entropy-driven single molecule tug-of-war (TOW) at two micro-nanofluidic interfaces bridged by a nanoslit, performed the force analysis from a modified worm-like chain in the TOW scenario and the entropic recoiling process, and determined the associated scalings on the nanoconfinement. Our results provide a direct experimental evidence that the entropic forces in these two regimes, though unequal, are essentially constant at defined slit heights, irrespective of the slit lengths and the DNA segments within. Our findings have the implications to polymer transport at the nanoscale, device design for single molecule analysis, and biotechnological applications.
Jia-Wei Yeh, Alessandro Taloni, Yeng-Long Chen, Chia-Fu Chou*, 2012, “Entropy-driven single molecule tug-of-war of DNA at micro-nanofluidic interfaces (Research Highlighted by Nature)”, NANO LETTERS, 12 (3), 1597–1602. (SCI) (IF: 12.08; SCI ranking: 11.9%,10.9%,6.2%,8.8%,6.7%,7.5%)
(2) 西元年:2012
研究人員(英):CHOU, CHIA-FU, Kuo-Tang Liao
研究成果名稱(英):Nanoscale molecular traps and dams for ultrafast protein enrichment in high-conductivity buffers
簡要記述(英):We report a new approach, termed molecular dam, to enhance mass transport for protein enrichment in nanofluidic channels by nanoscale electrodeless dielectrophoresis under physiological buffer conditions. Dielectric nanoconstrictions, down to 30nm in size, embedded in nanofluidic device, serve as field focusing lens capable of magnifying the applied field to 100000-fold when combined with a micro-to-nanofluidic step interface. Empowered by this strong field and the associated field gradient occurred at the nanoconstrictions, we demonstrate proteins are enriched by molecular damming effect, faster than the trapping effect, to greater than 100000-fold in 20 seconds, which is orders of magnitude faster than most reported methods. Our study opens up further possibilities of using nanoscale molecular dams in miniaturized sensing plat-forms for rapid and sensitive protein analysis and biomarker discovery, with potential applications in precipitation studies and protein crystallization, and possible extensions to small molecules enrichment or screening.
Kuo-Tang Liao, Chia-Fu Chou*, 2012, “Nanoscale molecular traps and dams for ultrafast protein enrichment in high-conductivity buffers (Featured in JACS Spotlights)”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134 (21), 8742−8745. (SCI) (IF: 14.357; SCI ranking: 4.7%)
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