Hwu, Yeu-Kuang / Adjunct Research Fellow

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Contact Information

Education

  • Ph. D. University of Wisconsin Madison

Secretary

Lee, Fu Fang / 886-2-2789-8985

fiona [at] phys.sinica.edu.tw

Research Interest

  • Application Research of Synchrotron Radiation
  • Photoelectron Spectromicroscopy Using Synchrotron Radiation

獎項及殊榮

(1) 國內學術研究獎項 2016-03 科技部104年度傑出研究獎
(2) 國內學術研究獎項 2015-12 第十二屆 國家新創獎之學研新創獎
(3) 國內學術研究獎項 2010 科技部台法科技獎
(4) 國內學術研究獎項 2005 行政院傑出科技榮譽獎
(5) 國內學術研究獎項 2004 國科會傑出研究獎

Experience

  • Assistant Research Fellow, Academia Sinica

Research Achievements

Journal Papers

  • [1]     Chin An-Lun, Yang Shun-Min, Chen Hsiang-Hsin, Li Min-Tsang, Lee Tsung-Tse, Chen Ying-Jie, Lee Ting-Kuo, Petibois Cyril, Cai Xiaoqing, Low Chian-Ming, Tan Francis Chee Kuan, Teo Alvin, Tok Eng Soon, Ong Edwin B.L., Lin Yen-Yin, Lin I-Jin, Tseng Yi-Chi, Chen Nan-Yow, Shih Chi-Tin, Lim Jae-Hong, Lim Jun, Je Jung-Ho, Kohmura Yoshiki, Ishikawa Tetsuya, Margaritondo Giorgio, Chiang Ann-Shyn, Hwu Yeukuang, 2020, “A synchrotron X-ray imaging strategy to map large animal brains”, Chinese Journal of Physics, 65 24-32. (SCIE) (IF: 3.957; SCI ranking: 30.2%)

  • [2]     Hwu Yeukuang, Margaritondo Giorgio, 2020, “Synchrotron Radiation and Sensors: a History of Synergies”, IEEE Sensors Journal, 1-1. (SCIE) (IF: 4.325; SCI ranking: 29.9%,21.9%,29.2%)

  • [3]     Yang Shin-Ruen, Hua Kuo-Feng, Chu Lichieh Julie, Hwu Yeu-Kuang, Yang Shun-Min, Wu Chung-Yao, Lin Tsai-Jung, Weng Jui-Chun, Zhao Hailin, Hsu Wan-Han, Liu Feng-Cheng, Liaw Wen-Jinn, Ma Daqing, Ka Shuk-Man, Chen Ann, 2020, “Xenon blunts NF-κB/NLRP3 inflammasome activation and improves acute onset of accelerated and severe lupus nephritis in mice”, Kidney International, 98(2) 378-390. (SCIE) (IF: 18.998; SCI ranking: 3.3%)

  • [4]     Huang Chi-Feng, Chang Wei-Hau, Lee Ting-Kuo, Joti Yasumasa, Nishino Yoshinori, Kimura Takashi, Suzuki Akihiro, Bessho Yoshitaka, Lee Tsung-Tse, Chen Mei-Chun, Yang Shun-Min, Hwu Yeukuang, Huang Shih-Hsin, Li Po-Nan, Chen Peilin, Tseng Yung-Chieh, Ma Che, Hsu Tsui-Ling, Wong Chi-Huey, Tono Kensuke, Ishikawa Tetsuya, Liang Keng S., 2020, “XFEL coherent diffraction imaging for weakly scattering particles using heterodyne interference”, AIP Advances, 10(5) 055219. (SCIE) (IF: 1.697; SCI ranking: 81.5%,86.4%,74.5%)

  • [5]     Yang Jhih-Heng, Chen Ning-Jung, Hwu YeuKuang, Chen Chien-Chun, 2019, “Algorithm for characterizing the subcellular structures of nanometer-sized biological specimens in a solution using x-ray free-electron lasers”, Physical Review Materials, 3(12). (SCIE) (IF: 3.98; SCI ranking: 46.2%)

  • [6]     Coburn David Scott, Nazaretski Evgeny, Xu Weihe, Ge Mingyuan, Longo Cindy, Xu Huijuan, Gofron Kazimierz, Yin Zhijian, Chen Huang Han, Hwu Yeukuang, Lee Wah-Keat, 2019, “Design, characterization, and performance of a hard x-ray transmission microscope at the National Synchrotron Light Source II 18-ID beamline”, Review of Scientific Instruments, 90(5) 053701. (SCIE) (IF: 1.843; SCI ranking: 65.6%,71.4%)

  • [7]     Li Min-Tsang, Lai Sheng-Feng, Yang Shun-Min, Chen Yu-Sheng, Chen Ying-Jie, Tok Eng Soon, Margaritondo Giorgio, Hwu Yeukuang, 2019, “Gold nano-mesh synthesis by continuous-flow X-ray irradiation”, Journal of Synchrotron Radiation, 26(6) 1929-1935. (SCIE) (IF: 2.557; SCI ranking: 46.9%,49%,52.8%)

  • [8]     Lu Chieh-Han, Tang Wei-Chun, Liu Yen-Ting, Chang Shu-Wei, Wu Frances Camille M., Chen Chin-Yi, Tsai Yun-Chi, Yang Shun-Min, Kuo Chiung-Wen, Okada Yasushi, Hwu Yeu-Kuang, Chen Peilin, Chen Bi-Chang, 2019, “Lightsheet localization microscopy enables fast, large-scale, and three-dimensional super-resolution imaging”, Communications Biology, 2(1). (SCIE) (IF: 6.548; SCI ranking: 16%)

  • [9]     Chu Li-An, Lu Chieh-Han, Yang Shun-Min, Liu Yen-Ting, Feng Kuan-Lin, Tsai Yun-Chi, Chang Wei-Kun, Wang Wen-Cheng, Chang Shu-Wei, Chen Peilin, Lee Ting-Kuo, Hwu Yeu-Kuang, Chiang Ann-Shyn, Chen Bi-Chang, 2019, “Rapid single-wavelength lightsheet localization microscopy for clarified tissue”, Nature Communications, 10(1). (SCIE) (IF: 17.694; SCI ranking: 8.1%)

  • [10]     Chang Wei-Ling, Wu Hao, Chiu Yu-Kun, Wang Shuo, Jiang Ting-Xin, Luo Zhong-Lai, Lin Yen-Cheng, Li Ang, Hsu Jui-Ting, Huang Heng-Li, Gu How-Jen, Lin Tse-Yu, Yang Shun-Min, Lee Tsung-Tse, Lai Yung-Chi, Lei Mingxing, Shie Ming-You, Yao Cheng-Te, Chen Yi-Wen, Tsai J.C., Shieh Shyh-Jou, Hwu Yeu-Kuang, Cheng Hsu-Chen, Tang Pin-Chi, Hung Shih-Chieh, Chen Chih-Feng, Habib Michael, Widelitz Randall B., Wu Ping, Juan Wen-Tau, Chuong Cheng-Ming, 2019, “The Making of a Flight Feather: Bio-architectural Principles and Adaptation”, Cell, 179(6) 1409-1423.e17. (SCIE) (IF: 66.85; SCI ranking: 0.7%,1.5%)

  • [11]     Chang-Chieh Cheng, Yu-Tai Ching*, Pai-Hung Ko, Yeukuang Hwu, 2018, “Correction of center of rotation and projection angle in synchrotron X-ray computed tomography”, SCIENTIFIC REPORTS, 8(1):9884. (SCIE) (IF: 4.997; SCI ranking: 25.7%)

  • [12]     Hsiang-Hsin Chen, Tsung-Tse Lee, Ann Chen, Yeukuang Hwu, Cyril Petibois*, 2018, “3D Digital Pathology for a Chemical-Functional Analysis of Glomeruli in Health and Pathology”, ANALYTICAL CHEMISTRY, 90 (6), 3811–3818. (SCIE) (IF: 8.008; SCI ranking: 8%)

  • [13]     Abiodun Ogunleke, Benoit Recur, Hugo Balacey, Hsiang-Hsin Chen, Maylis Delugin, Yeukuang Hwu, Sophie Javerzat, Cyril Petibois*, 2018, “3D chemical imaging of the brain using quantitative IR spectro-microscopy.”, CHEMICAL SCIENCE, 9(1), 189-198. (SCIE) (IF: 9.969; SCI ranking: 13.9%)

  • [14]     Chi-Feng Huang, Keng S. Liang, Tsui-Ling Hsu, Tsung-Tse Lee, Yi-Yun Chen, Shun-Min Yang, Hsiang-Hsin Chen, Shih-Hsin Huang, Wei-Hau Chang, Ting-Kuo Lee, Peilin Chen, Kuei-En Peng, Chien-Chun Chen, Cheng-Zhi Shi, Yu-Fang Hu, Giorgio Margaritondo, Tetsuya Ishikawa, Chi-Huey Wong, YeuKuang Hwu*, 2018, “Free-Electron-Laser Coherent Diffraction Images Individual Drug-Carrying Liposome Particles in Solution”, Nanoscale, 10, 2820-2824. (SCIE) (IF: 8.307; SCI ranking: 20.6%,20.2%,28.2%,14.3%)

  • [15]     Hu Chun-Chih, Wu Gong-Her, Lai Sheng-Feng, Muthaiyan Shanmugam Muniesh, Hwu Y., Wagner Oliver I., Yen Ta-Jen, 2018, “Toxic Effects of Size-tunable Gold Nanoparticles on Caenorhabditis elegans Development and Gene Regulation”, Scientific Reports, 8(1). (SCIE) (IF: 4.997; SCI ranking: 25.7%)

  • [16]     Yeukuang Hwu, Giorgio Margaritondo, Ann-Shyn Chiang*, 2017, “Q&A: Why use synchrotron x-ray tomography for multi-scale connectome mapping”, BMC BIOLOGY, 15:122. (SCIE) (IF: 7.364; SCI ranking: 10.6%)

  • [17]     E. Nazaretski, H. Yan, K. Lauer, N. Bouet, X. Huang, W. Xu, J. Zhou, D. Shu, Y. Hwu, Y. Chu*, 2017, “Design and performance of a hard x-ray scanning microscope at the nanoprobe beamline of NSLS-II.”, JOURNAL OF SYNCHROTRON RADIATION, 24, 1113–1119. (SCIE) (IF: 2.557; SCI ranking: 46.9%,49%,52.8%)

  • [18]     Yung‐Chieh Liu, Wen‐Sung Chung, Chun‐Chieh Yu, Su‐Ting Hsu, Fung‐Lan Chan, Tsung‐Han Liu, Chia‐Hao Su, Yeukuang Hwu, N. Justin Marshall, Chuan‐Chin Chiao, 2017, “Morphological changes of the optic lobe from late embryonic to adult stages in oval squids Sepioteuthis lessoniana.”, Journal of Morphology, 279(1), 75-85. (SCIE) (IF: 1.966; SCI ranking: 57.1%)

  • [19]     Yu-Chuan Lin, Yeukuang Hwu, Guo-Shu Huang, Michael Hsiao, Tsung-Tse Lee, Shun-Min Yang, Ting-Kuo Lee, Nan-Yow Chen, Sung-Sen Yang, Ann Chen*, Shuk-Man Ka *, 2017, “Differential synchrotron X-ray imaging markers based on the renal microvasculature for tubulointerstitial lesions and glomerulopathy.”, SCIENTIFIC REPORTS, 7(1), 3488. (SCIE) (IF: 4.997; SCI ranking: 25.7%)

  • [20]     Abiodun Ogunleke, Vladimir Bobroff, Hsiang-Hsin Chen, Jeremy Rowlette, Maylis Delugin, Benoit Recur, Yeukuang Hwu, Cyril Petibois*, 2017, “Fourier-transform vs. quantum-cascade-laser infrared microscopes for histo-pathology: From lab to hospital?”, TrAC Trends in Analytical Chemistry, 89, 190-196. (SCIE) (IF: 14.908; SCI ranking: 1.1%)

  • [21]     Feby Wijaya Pratiwi, Chih-Hao Hsia, Chiung Wen Kuo*, Shun-Min Yang, Yeu-Kuang Hwu, Peilin Chen*, 2016, “CONSTRUCTION OF SINGLE FLUOROPHORE RATIOMETRIC PH SENSORS USING DUAL-EMISSION MN(2+)-DOPED QUANTUM DOTS.”, Biosens Bioelectron, 29(84),133-140. (SCIE) (IF: 12.545; SCI ranking: 4.2%,6.2%,3.4%,10%,14.5%)

  • [22]     Cheng Chang-Chieh, Hwu Yeukuang, Ching Yu-Tai*, 2016, “High-resolution and large-volume tomography reconstruction for x-ray microscopy”, Medical Imaging 2016: Physics of Medical Imaging, 9783, 7-14.

  • [23]     Sheng-Feng Lai, Bai-Hung Ko, Chia-Chi Chien, Chia-Ju Chang, Shun-Ming Yang, Hsiang-Hsin Chen, Cyril Petibois, Dueng-Yuan HuengEmail author, Shuk- Man Ka, Ann Chen, G. Margaritondo, YeuKuang Hwu*, 2015, “Gold nanoparticles as multimodality imaging agents for brain gliomas”, JOURNAL OF NANOBIOTECHNOLOGY, 13:85. (SCIE) (IF: 9.429; SCI ranking: 8.7%,26.4%)

  • [24]     Pei-Cheng Hsu, Edwin B. L. Ong, Chang-Hai Wang, YeuKuang Hwu*, J. H. Je, and G. Margaritondo, Eng Soon Tok, 2015, “X-ray-induced Cu deposition and patterning on insulators at room temperature.”, JOURNAL OF SYNCHROTRON RADIATION, 22, 1524-1527. (SCIE) (IF: 2.557; SCI ranking: 46.9%,49%,52.8%)

  • [25]     Min-Tsang Li, Chang-Hai Wang, Sheng-Feng Lai, Edwin B. L. Ong, Y. H. Chen, Chung-Kwei Lin, G. Margaritondo, YeuKuang Hwu*, 2015, “X-ray irradiation synthesis of PEG-coated Au-Pd nanoparticles”, NANOTECHNOLOGY, 26(35), 355601-355609. (SCIE) (IF: 3.953; SCI ranking: 46.5%,58.2%,31.7%)

  • [26]     Min-Tsang Li, Chang-Hai Wang, Sheng-Feng Lai, Yu-Han Chen, Edwin B. L. Ong, Chung-Kwei Lin, G. Margaritondo, YeuKuang Hwu*, 2015, “Catalytic properties of uncapped Au-Pd nanoparticles”, RSC ADVANCES, 5, 61846–61850. (SCIE) (IF: 4.036; SCI ranking: 41.7%)

  • [27]     Sheng-Feng Lai, Hui Ru Tan, Eng Soon Tok, Yu-Han Chen, Edwin B. L. Ong, Min-Tsang Li, Yi-Yun Chen, Fan-Ching Chien, Peilin Chen, Giorgio Margaritondo, Yeukuang Hwu*, 2015, “Optimization of Gold Nanoparticle Photoluminescence by Alkanethiolation”, CHEMICAL COMMUNICATIONS, 51, 7954-7957. (SCIE) (IF: 6.065; SCI ranking: 29.4%)

  • [28]     Chien-Hung Chen, Fong-Sian Lin, Wei-Neng Liao, Sanching L. Liang, Min-Hua Chen, Yo-Wen Chen, Wan-Yu Lin, Ming-Hua Hsu, Mei-Ya Wang, Jinn-Jer Peir, Fong-In Chou, Chin-Ya Chen, Sih-Yu Chen, Su-Chin Huang, Mo-Hsiung Yang, Dueng-Yuan Hueng, Yeukuang Hwu, Chung-Shi Yang*, and Jen-Kun Chen*, 2015, “Establishment of a Trimodality Analytical Platform for Tracing, Imaging and Quantification of Gold Nanoparticles in Animals by Radiotracer Techniques”, ANALYTICAL CHEMISTRY, 87(1):601-608. (SCIE) (IF: 8.008; SCI ranking: 8%)

  • [29]     Kuo-Hao Lee, Sheng-Feng Lai, Yan-Cheng Lin, Wu-Ching Chou, Edwin B.L. Ong, Hui-Ru Tan, Eng Soon Tok, C. S. Yang, G. Margaritondo and Y. Hwu*, 2015, “Gold Nanoparticles: BSA (Bovine Serum Albumin) Coating and X-ray Irradiation Produce Variable-spectrum Photoluminescence ”, MATERIALS CHEMISTRY AND PHYSICS, 149-150, 582-586. (SCIE) (IF: 4.778; SCI ranking: 36.1%)

  • [30]     Albertin F., Astolfo A., Stampanoni M., Peccenini Eva, Hwu Y., Kaplan F., Margaritondo G., 2015, “Ancient administrative handwritten documents: X-ray analysis and imaging”, Journal of Synchrotron Radiation, 22(2) 446-451. (SCIE) (IF: 2.557; SCI ranking: 46.9%,49%,52.8%)

  • [31]     Lee Su Yong, Noh Do Young, Lee Hae Cheol, Yu Chung-Jong, Hwu Yeukuang, Kang Hyon Chol, 2015, “Direct-write X-ray lithography using a hard X-ray Fresnel zone plate”, Journal of Synchrotron Radiation, 22(3) 781-785. (SCIE) (IF: 2.557; SCI ranking: 46.9%,49%,52.8%)

  • [32]     Bao L.M., Zhang G.L., Lei Q.T., Li Y., Li X.L., Hwu Y.K., Yi J.M., 2015, “Microstructure of atmospheric particles revealed by TXM and a new mode of influenza virus transmission”, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 359 167-172.

  • [33]     Albertin Fauzia, Astolfo Alberto, Stampanoni Marco, Peccenini Eva, Hwu Yeukuang, Kaplan Frédé́ric, Margaritondo Giorgio, 2015, “X-ray spectrometry and imaging for ancient administrative handwritten documents”, X-Ray Spectrometry, 44(3) 93-98. (SCIE) (IF: 1.234; SCI ranking: 74.4%)

  • [34]     Yueh-Lin Tsai, Chia-Wei Li,* Tzay-Ming Hong, Jen-Zon Ho, En-Cheng Yang, Wen-Yen Wu,G. Margaritondo, Su-Ting Hsu, Edwin B. L. Ong, and Y. Hwu, 2014, “Firefly Light Flashing: Oxygen Supply Mechanism”, PHYSICAL REVIEW LETTERS, 113, 258103. (SCIE) (IF: 9.185; SCI ranking: 9.3%)

  • [35]     Chan Kim, Yoonhee Kim, Changyong Song, Sang Soo Kim, Sunam Kim, Hyon Chol Kang, Yeukuang Hwu, Ku-Ding Tsuei, Keng San Liang, and Do Young Noh*, 2014, “Resolution enhancement in coherent x-ray diffraction imaging by overcoming instrumental noise ”, OPTICS EXPRESS, 22, 29161–29169. (SCIE) (IF: 3.833; SCI ranking: 27.5%)

  • [36]     Cyril Petibois*, Vladimir Bobroff, Adrian Travo, Hsiang-Hsin Chen, Sophie Javerzat, YeuKuang Hwu, 2014, “Application of X-ray/Infrared multimodal imaging on nanoparticles in glioma research”, JOURNAL OF NEUROCHEMISTRY, 130, 23-23. (SCIE) (IF: 5.546; SCI ranking: 31.3%,26.5%)

  • [37]     Y. Hwu* and Edwin B. L. Ong, 2014, “X-ray nanotechnology for biomedical imaging”, JOURNAL OF NEUROCHEMISTRY, 130, 23-23. (SCIE) (IF: 5.546; SCI ranking: 31.3%,26.5%)

  • [38]     Xiaojing Huang, Hanfei Yan, Ross Harder, Yeukuang Hwu, Ian K. Robinson, and Yong S. Chu*, 2014, “Optimization of overlap uniformness for ptychography ”, OPTICS EXPRESS, 22 12634. (SCIE) (IF: 3.833; SCI ranking: 27.5%)

  • [39]     Chia-Ling Chan, Kai K. Ewert, Ramsey N.Majzoub, Yeu-Kuang Hwu, Keng S. Liang, Cecilia Leal, Cyrus R Safinya, 2014, “Optimizing cationic and neutral lipids for efficient gene delivery at high serum content”, JOURNAL OF GENE MEDICINE, 16(3-4) 84-96. (SCIE) (IF: 4.152; SCI ranking: 39.8%,40.1%,52.9%)

  • [40]     Pei-Rung Wu, Bo-Rui Chen, Chi-Chun Hsieh, Wei-Chung Lin, Kenneth K. Wu, Yeukuang Hwu and Pei-Feng Chen, 2014, “The N-terminal portion of autoinhibitory element modulates human endothelial nitric-oxide synthase activity through coordinated controls of phosphorylation at Thr(495) and Ser(1177)”, BIOSCIENCE REPORTS, 34 443-455. (SCIE) (IF: 3.977; SCI ranking: 55.6%,62.6%)

  • [41]     E. Nazaretski, X. Huang, H. Yan, K. Lauer, R. Conley, N. Bouet, J. Zhou, W. Xu, D. Eom, D. Legnini, R. Harder, C.-H. Lin, Y.-S. Chen, Y. Hwu and Y. S. Chu*, 2014, “Design and performance of a scanning ptychography microscope”, REVIEW OF SCIENTIFIC INSTRUMENTS, 85, 033707. (SCIE) (IF: 1.843; SCI ranking: 65.6%,71.4%)

  • [42]     Yu-Chuen Huang, Yuh-Cheng Yang, Kai-Chien Yang, Hui-Ru Shieh, Tao-Yeuan Wang, Yeukuang Hwu, and Yu-Jen Chen, 2014, “Pegylated Gold Nanoparticles Induce Apoptosis in Human Chronic Myeloid Leukemia Cells”, BioMed Research International, 2014, 182353. (SCIE) (IF: 3.246; SCI ranking: 55.9%,65%)

  • [43]     Yu-Sheng Chen, Huang-Han Chen, Tsung-Tse Li, Edwin Ong, Jun Lim, Giorgio Margaritondo, En-Te Hwu and Yeukuang Hwu*, 2014, “A Compact Synchrotron-based Transmission X-ray Microscope”, JOURNAL OF SYNCHROTRON RADIATION, 21, 376-9. (SCIE) (IF: 2.557; SCI ranking: 46.9%,49%,52.8%)

  • [44]     Chang-Chieh Cheng, Chia-Chi Chien, Hsiang-Hsin Chen, Yeukuang Hwu, Yu-Tai Ching *, 2014, “Image Alignment for Tomography Reconstruction from Synchrotron X-Ray Microscopic Images”, PLoS One, 9(1): e84675. (SCIE) (IF: 3.752; SCI ranking: 39.2%)

  • [45]     S. R. Wu, C. H. Lin, Y. S. Chen, Y. Y. Chen, Y. Hwu*, Y. S. Chu, G. Margaritondo: “, 2013, “At the frontiers of high-resolution hard-x-ray microscopy: an international programme”, JOURNAL OF PHYSICS D-APPLIED PHYSICS, 46 (49) 494005. (SCIE) (IF: 3.409; SCI ranking: 37.9%)

  • [46]     Y. Hwu, G. Margaritondo, 2013, “Phase contrast: the frontier of x-ray and electron imaging PREFACE”, JOURNAL OF PHYSICS D-APPLIED PHYSICS, 46 (49) 490301. (SCIE) (IF: 3.409; SCI ranking: 37.9%)

  • [47]     En-Te Hwu,*, Evgeny Nazaretski, Yong S. Chu, Huang-Han Chen, Yu-Sheng Chen, Weihe Xu and Yeukuang Hwu: “, 2013, “Design and characterization of a compact nano-positioning system for a portable transmission x-ray microscope ”, REVIEW OF SCIENTIFIC INSTRUMENTS, 84, 123702. (SCIE) (IF: 1.843; SCI ranking: 65.6%,71.4%)

  • [48]     Razia Noreen, Chia-Chi Chien, Hsiang-Hsin Chen, Vladimir Bobroff, Michel Moenner, Sophie Javerzat, Yeukuang Hwu, Cyril Petibois, 2013, “FTIR spectro-imaging of collagen scaffold formation during glioma tumor development ”, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 405 (27), 8729-8736. (SCIE) (IF: 4.478; SCI ranking: 31.6%,25.3%)

  • [49]     Ching-Ping Liu, Fong-Sian Lin, Chih-Te Chien, Sheng-Yang Tseng, Chih-Wei Luo, Chien-Hung Chen, Jen-Kun Chen, Fan-Gang Tseng, Yeukuang Hwu, Leu-Wei Lo, Chung-Shi Yang, Shu-Yi Lin, 2013, “In-situ formation and assembly of gold nanoparticles by gum arabic as efficient photothermal agent for killing cancer cells ”, MACROMOLECULAR BIOSCIENCE, 13(10) 1314-1320. (SCIE) (IF: 5.859; SCI ranking: 26.3%,32.6%,12.2%)

  • [50]     C. Petibois, Y. Hwu, 2013, “Morpho-spectral imaging in the biosciences”, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 405 (27), 8699-8700. (SCIE) (IF: 4.478; SCI ranking: 31.6%,25.3%)

  • [51]     Tsai, Mu-Gong; Tung, Hsien-Tse; Chen, In-Gann; Chen, Chia-Chuan; Wu, Yun-Fang; Qi, Xiaoding; Hwu, Y; Lin, Cen-Ying; Wu, u, Ping-Han; Cheng, Cheng, Chung-Wei, 2013, “Annealing Effect on the Properties of Cu(In0.7Ga0.3)Se2 Thin Films Grown by Femtosecond Pulsed Laser Deposition” ”, JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 96 2419-2423. (SCIE) (IF: 4.186; SCI ranking: 17.2%)

  • [52]     S.-Ja Tseng, Ivan M. Kempson, Shu-Fen Peng, Bai-Hung Ke, Hsiang-Hisn Chen, Pei-Feng Chen, Y. Hwu*, 2013, “Using charge-reversal and size oscillation of polyelectrolytes through pH-dependence medium for localized recombinant adeno-associated virus serotype 2 delivery”, JOURNAL OF CONTROLLED RELEASE, 170, 252. (SCIE) (IF: 11.467; SCI ranking: 12.2%,4.3%)

  • [53]     Chia-Chi Chien, Ivan M. Kempson, C. L. Wang, H. S. Chen, Y. Hwu*, N. Y. Chen, T. K. Lee, Cyril Petibois, Kelvin K.-C. Tsai*, Ming-Sheng Liu, Kwang-Yu Chang, C. S. Yang, G. Margaritondo, 2013, “Complete microscale profiling of tumor microangiogenesis: A microradiological methodology reveals fundamental aspects of tumor angiogenesis and yields an array of quantitative parameters for its characterization”, BIOTECHNOLOGY ADVANCES, 31(3), 396-401. (SCIE) (IF: 17.681; SCI ranking: 3.1%)

  • [54]     C. C. Chien, P. Y. Tseng, H. H. Chen, T. E. Hua, S. T. Chen, Y. Y. Chen,W. H. Leng, C. H. Wang, Y. Hwu, G. C. Yin, K. S. Liang, F. R. Chen, Y. S. Chu, H. I. Yeh, C. S. Yang, G. L. Zhang, J. H. Je, and G. Margaritondo, 2013, “Imaging Cells and Sub-Cellular Structures with Ultrahigh Resolution Full-Field X-ray Microscopy”, BIOTECHNOLOGY ADVANCES, (2013), 31(3) 375-86.. (SCIE) (IF: 17.681; SCI ranking: 3.1%)

  • [55]     Sheng-Feng Lai, Chia-Chi Chien, Wen-Chang Chen Hsiang-Hsin Chen, Yi-Yun Chen, Cheng-Liang Wang, Y. Hwu*, C. S. Yang, C. Y. Chen, K. S. Liang, C. Petibois and G. Margaritondo, 2013, “Very small photoluminescent gold nanoparticles for multimodality”, BIOTECHNOLOGY ADVANCES, 31(3), 362-268. (SCIE) (IF: 17.681; SCI ranking: 3.1%)

  • [56]     Wei-Syuan Lin, Hong-Ming Lin, Hsiang-Hsin Chen, Yeu-Kuang Hwu, Yuh-Jing Chiou, 2013, “Shape Effects of Iron Nanowires on Hyperthermia Treatment”, J Nanomaterials, 2013, 237439.

  • [57]     G. Margaritondo and Y. Hwu, 2013, “The New Birth of Radiology – more than One Century after Röntgen”, Nuovo Saggiatore, 29, 45.

  • [58]     Hsien-Tse Tung, In-Gann Chen, Jenn-Ming Song, Mu-Gong Tsai, Ivan M. Kempson, Giorgio Margaritondo and Yeukuang Hwu*, 2013, “Cu(In1-xGax)S2 nanocrystals and films: low-temperature synthesis with size and composition control”, Nanoscale, 5, 4706-4710. (SCIE) (IF: 8.307; SCI ranking: 20.6%,20.2%,28.2%,14.3%)

  • [59]     Wei-Syuan Lin, Zih-Jie Jian, Hong-Ming Lin*, Li-Chung Lai, Wen-An Chiou, Yeu-Kuang Hwu, She-Huang Wu, Wen-Chang Chen, Y. D. Yao, 2013, “Synthesis and Characterization of Iron Nanowires”, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 60(1), 85-91. (SCIE) (IF: 1.753; SCI ranking: 75%)

  • [60]     Cheng-Lung Chen*, Ling-Ru Kuo, Shin-Yu Lee, Yeu-Kuang Hwu, Shang-Wei Chou, Chia-Chun Chen, Fu-Hsiung Chang, Kung-Hsuan Lin, Dzung-Han Tsai, Yang-Yuan Chen, 2013, “Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles”, BIOMATERIALS, 34(4), 1128-1134. (SCIE) (IF: 15.304; SCI ranking: 4.1%,6.5%)

  • [61]     Changhai Wang*, Frederick Casper, Yanzhi Guo, Teuta Gasi, Vadim Ksenofontov, Benjamin Balke, Gerhard H. Fecher, Claudia Felser, Yeu-Kuang Hwu, Jey-Jau Lee, 2012, “Resolving the phase structure of nonstoichiometric Co2FeGa Heusler nanoparticles”, JOURNAL OF APPLIED PHYSICS, 112(12). (SCIE) (IF: 2.877; SCI ranking: 46%)

  • [62]     Seung-Kwon Seol*, Daeho Kim, Sunshin Jung, Won-Suk Chang, Young-Min Bae, Kyeong-Hee Lee, Yeukuang Hwu, 2012, “Effect of citrate on poly(vinyl pyrrolidone)-stabilized gold nanoparticles formed by PVP reduction in microwave (MW) synthesis”, MATERIALS CHEMISTRY AND PHYSICS, 137(1), 135-139. (SCIE) (IF: 4.778; SCI ranking: 36.1%)

  • [63]     Ivan M. Kempson*, Chia-Chi Chien, Chao-Yu Chung, Yeukuang Hwu, David Paterson, Martin D. de Jonge, Daryl L. Howard, 2012, “Fate of Intravenously Administered Gold Nanoparticles in Hair Follicles: Follicular Delivery, Pharmacokinetic Interpretation, and Excretion”, ADVANCED HEALTHCARE MATERIALS, 1(6), 736-741. (SCIE) (IF: 11.092; SCI ranking: 8.2%,8.7%,19.1%)

  • [64]     Razia Noreen, Michel Moenner, Yeukuang Hwu , Cyril Petibois*, 2012, “FTIR spectro-imaging of collagens for characterization and grading of gliomas”, BIOTECHNOLOGY ADVANCES, 30(6), 1432-1446. (SCIE) (IF: 17.681; SCI ranking: 3.1%)

  • [65]     Hsien-Tse Tung, In-Gann Chen, Ivan M. Kempson, Jenn-Ming Song, Yu-Feng Liu, Po-Wei Chen, Weng-Sing Hwang, Yeukuang Hwu*, 2012, “Shape-Controlled Synthesis of Silver Nanocrystals by X-ray Irradiation for Inkjet Printing”, ACS Applied Materials & Interfaces, 4(11), 5930-5935. (SCIE) (IF: 10.383; SCI ranking: 14.2%,20.9%)

  • [66]     Syue-Ren Wu, Yeukuang Hwu*, Giorgio Margaritondo, 2012, “Hard-X-ray Zone Plates: Recent Progress”, MATERIALS, 5(10), 1752-1773. (SCIE) (IF: 3.748; SCI ranking: 51.5%,51.2%,22.8%,34.8%,40.6%)

  • [67]     Nai-Tzu Chen, Chia-Yan Wu, Chao-Yu Chung, Yeukuang Hwu, Shih-Hsun Cheng, Chung-Yuan Mou*, Leu-Wei Lo, 2012, “Probing the Dynamics of Doxorubicin-DNA Intercalation during the Initial Activation of Apoptosis by Fluorescence Lifetime Imaging Microscopy (FLIM)”, PLOS ONE, 7(9),. (SCIE) (IF: 3.752; SCI ranking: 39.2%)

  • [68]     C-C. Chien, C-C. Cheng, H. H. Chen, Y. Hwu*, Y. S. Chu, C. Petibois, A. Chen, Y-T. Ching, G. Margaritondo, 2012, “X-ray microscopy and tomography detect the accumulation of bare and PEG-coated gold nanoparticles in normal and tumor mouse tissues”, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 404(5), 1287-1296. (SCIE) (IF: 4.478; SCI ranking: 31.6%,25.3%)

  • [69]     Chia-Chi Chien, Hsiang-Hsin Chen, Sheng-Feng Lai, Y. Hwu*, Cyril Petibois, C. S. Yang, Y. Chu, G. Margaritondo, 2012, “X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells”, SCIENTIFIC REPORTS, 2. (SCIE) (IF: 4.997; SCI ranking: 25.7%)

  • [70]     Changhai Wang*, Frederick Casper, Teuta Gasi, Vadim Ksenofontov, Benjamin Balke, Gerhard H. Fecher, Claudia Felser, Yeu-Kuang Hwu, Jeu-Jau Lee, 2012, “Structural and magnetic properties of Fe2CoGa Heusler nanoparticles”, JOURNAL OF PHYSICS D-APPLIED PHYSICS, 45(29),. (SCIE) (IF: 3.409; SCI ranking: 37.9%)

  • [71]     Chia-Wei Wang, S-Ja Tseng, Shu-Fen Peng, Yeu-Kuang Hwu, Chung-Kwei Lin*, 2012, “Functionalized polymer spheres via one-step photoinduced synthesis for antimicrobial activity and gene delivery”, NANOTECHNOLOGY, 23(25),. (SCIE) (IF: 3.953; SCI ranking: 46.5%,58.2%,31.7%)

  • [72]     H. R. Wu, S. T. Chen, Y. S. Chu, R. Conley, N. Bouet, C. C. Chien, H. H. Chen, C. H. Lin, H. T. Tung, Y. S. Chen, G. Margaritondo, J. H. Je, Y. Hwu*, 2012, “Nanoresolution radiology of neurons”, JOURNAL OF PHYSICS D-APPLIED PHYSICS, 45(24). (SCIE) (IF: 3.409; SCI ranking: 37.9%)

  • [73]     H. R. Wu, S. T. Chen, Y. S. Chu, R. Conley, N. Bouet, C. C. Chien, H. H. Chen, C. H. Lin, H. T. Tung, Y. S. Chen, G. Margaritondo, J. H. Je, and Y. Hwu*, 2012, “Nanoresolution Radiology of Neurons”, JOURNAL OF PHYSICS D-APPLIED PHYSICS, 45, 242001. (SCIE) (IF: 3.409; SCI ranking: 37.9%)

  • [74]     Chun-Yu Chen*, Pei-Feng Chen, Yeukuang Hwu, U-Ser Jeng, Kun-Yu Wu, Keng S. Liang, 2012, “Envelope Structure of Human eNOS Protein Revealed by Small-Angle X-ray Scattering”, CHINESE JOURNAL OF PHYSICS, 50(2), 344-348. (SCIE) (IF: 3.957; SCI ranking: 30.2%)

  • [75]     C. C. Chien, P. Y. Tseng, H. H. Chen, T. E. Hua, S. T. Chen, Y. Y. Chen,W. H. Leng, C. H. Wang, Y. Hwu*, G. C. Yin, K. S. Liang, F. R. Chen, Y. S. Chu, H. I. Yeh, C. S. Yang, G. L. Zhang, J. H. Je, and G. Margaritondo, 2012, “Imaging Cells and Sub-Cellular Structures with Ultrahigh Resolution Full-Field X-ray Microscopy”, Biotechnology Advances, 31(3), 375-386. (SCIE) (IF: 17.681; SCI ranking: 3.1%)

  • [76]     Chia-Chi Chien, Hsiang-Hsin Chen, Sheng-Feng Lai, Kang-Chao Wu, Xiaoqing Cai, Yeukuang Hwu*, Cyril Petibois, Yong Chu, Giorgio Margaritondo, 2012, “Gold nanoparticles as high-resolution X-ray imaging contrast agents for the analysis of tumor-related micro-vasculature”, JOURNAL OF NANOBIOTECHNOLOGY, 10. (SCIE) (IF: 9.429; SCI ranking: 8.7%,26.4%)

  • [77]     Fong-Sian Lin*, Chih-Te Chien, Wan-Ching Chiu, Shu-Yi Lin, Fan-Gang Tseng, Yeukuang Hwu , Chung-Shi Yang, 2012, “Chemical auxiliary-free polymerization yielding non-linear PEG for protein-resistant application”, RSC ADVANCES, 2(18), 7174-7179. (SCIE) (IF: 4.036; SCI ranking: 41.7%)

  • [78]     S. -Ja Tseng, Chia-Chi Chien, Zi-Xian Liao, Hsiang-Hisn Chen, Yi-Da Kang, Cheng-Liang Wang, Y. Hwu*, G. Margaritondo, 2012, “Controlled hydrogel photopolymerization inside live systems by X-ray irradiation”, SOFT MATTER, 8(5), 1420-1427. (SCIE) (IF: 4.046; SCI ranking: 48.5%,43.9%,29.1%,27.8%)

  • [79]     Sheng-Feng Lai*, Chia-Chi Chien, Wen-Chang Chen, Yi-Yun Chen, Chang-Hai Wang, Y. Hwu, C. S. Yang, G. Margaritondo, 2012, “Size control of gold nanoparticles by intense X-ray irradiation: the relevant parameters and imaging applications”, RSC ADVANCES, 2(15). (SCIE) (IF: 4.036; SCI ranking: 41.7%)

  • [80]     Seung-Kwon Seol*, Daeho Kim, Sunshin Jung, Yeukuang Hwu, 2011, “Microwave synthesis of gold nanoparticles: Effect of applied microwave power and solution pH”, MATERIALS CHEMISTRY AND PHYSICS, 131(1-2), 331-335. (SCIE) (IF: 4.778; SCI ranking: 36.1%)

  • [81]     Jinkyung Kim, Namseop Kwon, Soeun Chang, Kyong-Tai Kim, Dongmyeong Lee, Seunghwan Kim, So-Jeong Yun, Daehee Hwang, Jee-Woong Kim, Yeukuang Hwu, Giorgio Margaritondo, Jung Ho Je*, Im-Joo Rhyu, 2011, “Altered branching patterns of Purkinje cells in mouse model for cortical development disorder”, SCIENTIFIC REPORTS, 1. (SCIE) (IF: 4.997; SCI ranking: 25.7%)

  • [82]     Tsung-Yu Chen*, Yu-Tung Chen, Cheng-Liang Wang, Ivan M. Kempson, Wah-Keat Lee, Yong S. Chu, Y. Hwu, G. Margaritondo, 2011, “Full-field microimaging with 8 keV X-rays achieves a spatial resolutions better than 20 nm”, OPTICS EXPRESS, 19(21), 19919-19924. (SCIE) (IF: 3.833; SCI ranking: 27.5%)

  • [83]     Shih-Hsun Cheng, Nai-Tzu Chen, Chia-Yan Wu, Chao-Yu Chung, Yeukuang Hwu, Chung-Yuan Mou, Chung-Shi Yang, Leu-Wei Lo*, 2011, “Recent Advances in Dynamic Monitoring of Drug Release of Nanoparticle Using Forster Resonance Energy Transfer and Fluorescence Lifetime Imaging”, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 58(6), 798-804. (SCIE) (IF: 1.753; SCI ranking: 75%)

  • [84]     Razia Noreen, Raphael Pineau, Chia-Chi Chien, Mariangela Cestelli-Guidi, Yeukuang Hwu, Augusto Marcelli, Michel Moenner, Cyril Petibois*, 2011, “Functional histology of glioma vasculature by FTIR imaging”, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 401(3). (SCIE) (IF: 4.478; SCI ranking: 31.6%,25.3%)

  • [85]     Xiaoqing Cai, Hsiang-Hsin Chen, Cheng-Liang Wang, Shin-Tai Chen, Sheng-Feng Lai, Chia-Chi Chien, Yi-Yun Chen, Ivan M. Kempson, Yeukuang Hwu* , C. S. Yang, G. Margaritondo, 2011, “Imaging the cellular uptake of tiopronin-modified gold nanoparticles”, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 401(3), 809-816. (SCIE) (IF: 4.478; SCI ranking: 31.6%,25.3%)

  • [86]     Sheng-Feng Lai, Wen-Chang Chen, Cheng-Liang Wang, Hsiang-Hsin Chen, Shin-Tai Chen, Chia-Chi Chien, Yi-Yun Chen, Wen-Ting Hung, Xiaoqing Cai, Enrong Li, Ivan M. Kempson, Y. Hwu*, C. S. Yang, Eng-Soon Tok, Hui-Ru Tan, Ming Lin, G. Margaritondo, 2011, “One-Pot Tuning of Au Nucleation and Growth: From Nanoclusters to Nanoparticles”, LANGMUIR, 27(13), 8424-8429. (SCIE) (IF: 4.331; SCI ranking: 40%,44.8%,39.9%)

  • [87]     Jaemock Yi*, Yong S. Chu, Yu-Tung Chen, Tsung-Yu Chen, Y. Hwu, G. Margaritondo, 2011, “High-resolution hard-x-ray microscopy using second-order zone-plate diffraction”, JOURNAL OF PHYSICS D-APPLIED PHYSICS, 44(23),. (SCIE) (IF: 3.409; SCI ranking: 37.9%)

  • [88]     Dong Woo Chang, Bora Kim, Jae Hoon Shin, Young Min Yun, Jung Ho Je, Yeu Kuang Hwu, Jung Hee Yoon, Je Kyung Seong*, 2011, “Real time observation of mouse fetal skeleton using a high resolution X-ray synchrotron”, JOURNAL OF VETERINARY SCIENCE, 12(2), 107-113.

  • [89]     W. Wang*, J. Chen, D. Y. Yu, B. Yang, Y. Hwu, M. W. Zhang, F. F. Ruan, X. H. Cai, 2011, “Transmission of electrons through a tapered glass capillary”, PHYSICA SCRIPTA, T144. (SCIE) (IF: 3.081; SCI ranking: 40.7%)

  • [90]     Lin-Ren Tsai, Min-Hua Chen, Chih-Te Chien, Meng-Kai Chen, Fong-Sian Lin, Kurt Ming-Chao Lin, Yeu-Kuang Hwu, Chung-Shi Yang, Shu-Yi Lin*, 2011, “A single-monomer derived linear-like PEI-co-PEG for siRNA delivery and silencing”, BIOMATERIALS, 32(14), 3647-3653. (SCIE) (IF: 15.304; SCI ranking: 4.1%,6.5%)

  • [91]     Yu-Tung Chen, Tsung-Yu Chen, Jaemock Yi, Yong S. Chu, Wah-Keat Lee, Cheng-Liang Wang, Ivan M. Kempson, Y. Hwu, Vincent Gajdosik, and G. Margaritondo*, 2011, “Hard x-ray Zernike microscopy reaches 30 nm resolution”, OPTICS LETTERS, 36(7), 1269-1271. (SCIE) (IF: 3.56; SCI ranking: 31.4%)

  • [92]     Hsiang-Hsin Chen, Chia-Chi Chien, Cyril Petibois, Cheng-Liang Wang, Yong S. Chu, Sheng-Feng Lai, Tzu-En Hua, Yi-Yun Chen, Xiaoqing Cai, Ivan M. Kempson, Yeukuang Hwu*, Giorgio Margaritondo, 2011, “Quantitative analysis of nanoparticle internalization in mammalian cells by high resolution X-ray microscopy”, JOURNAL OF NANOBIOTECHNOLOGY, 9. (SCIE) (IF: 9.429; SCI ranking: 8.7%,26.4%)

  • [93]     Enrong Li, Yeukuang Hwu*, David Chien, C L Wang and G Margaritondo, 2011, “Phase retrieval from integrated near-field diffraction intensity”, JOURNAL OF OPTICS, 13(3),.

  • [94]     Chang-Hai Wang, Chi-Jen Liu*, Chia-Chi Chien, Hsin-Tai Chen, Tzu-En Hua, Wei-Hua Leng, Hsiang-Hsin Chen, Ivan M. Kempson, Y. Hwu, Michael Hsiao, Tsung-Ching Lai, J.L. Wang, Chung-Shi Yang, Hong-Ming Lin, Yu-Jen Chen, G. Margaritondo, 2011, “X-ray synthesized PEGylated (polyethylene glycol coated) gold nanoparticles in mice strongly accumulate in tumors”, MATERIALS CHEMISTRY AND PHYSICS, 126(1-2), 352-356. (SCIE) (IF: 4.778; SCI ranking: 36.1%)

  • [95]     Cheng-Liang Wang*, Bo-Jun Hsao, Sheng-Feng Lai, Wen-Chang Chen, Hsiang-Hsin Chen, Yi-Yun Chen, Chia-Chi Chien, Xiaoqing Cai, Ivan M Kempson, Y Hwu and G Margaritondo, 2011, “One-pot synthesis of AuPt alloyed nanoparticles by intense x-ray irradiation”, NANOTECHNOLOGY, 22(6). (SCIE) (IF: 3.953; SCI ranking: 46.5%,58.2%,31.7%)

  • [96]     Hsien-Tse Tung, Yeukuang Hwu*, In-Gann Chen, Mu-Gong Tsai, Jenn-Ming Song, Ivan M. Kempson and Giorgio Margaritondo, 2011, “Fabrication of single crystal CuGaS2 nanorods by X-ray irradiation”, CHEMICAL COMMUNICATIONS, 47(32), 9152-9154. (SCIE) (IF: 6.065; SCI ranking: 29.4%)

  • [97]     Chia-Yan Wu, Chuan-Keng Huang, Chao-Yu Chung, I-Ping Huang, Yeukuang Hwu, Chung-Shi Yang, Yiu-Kay Lai, Leu-Wei Lo*and Su-Yu Chiang, 2011, “Probing the binding kinetics of proinflammatory cytokine-antibody interactions using dual color fluorescence cross correlation spectroscopy”, ANALYST, 136(10), 2111-2118. (SCIE) (IF: 5.227; SCI ranking: 20.7%)

  • [98]     Changhai Wang, Lubna Basit, Yuriy Khalavka, Yanzhi Guo, Frederick Casper, Teuta Gasi, Vadim Ksenofontov, Benjamin Balke, Gerhard H. Fecher, Carsten Sönnichsen, Yeu-Kuang Hwu, Jey-Jau Lee, and Claudia Felser*, 2010, “Probing the Size Effect of Co2FeGa-SiO2@C Nanocomposite Particles Prepared by a Chemical Approach”, CHEMISTRY OF MATERIALS, 22(24), 6575-6582. (SCIE) (IF: 10.508; SCI ranking: 18.8%,13.9%)

  • [99]     C. H. Wang, Y. Z. Guo, F. Casper, B. Balke, G. H. Fecher, C. Felser*, and Y. Hwu, 2010, “Size correlated long and short range order of ternary Co2FeGa Heusler nanoparticles”, APPLIED PHYSICS LETTERS, 97(10),. (SCIE) (IF: 3.971; SCI ranking: 31.1%)

  • [100]     Feng Liang, Guilin Zhang*, Xianghui Xiao, Zhonghou Cai, Barry Lai, Yeukuang Hwu, Chonghuai Yan, Jian Xu, Yulan Li, Mingguang Tan, Chuanfu Zhang, Yan Li, 2010, “Toxicological study of injuries of rat's hippocampus after lead poisoning by synchrotron microradiography and elemental mapping”, NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 268(17-18), 2840-2845. (SCIE) (IF: 1.279; SCI ranking: 84.4%,70.6%,88.9%,84.2%)

  • [101]     Xiaoqing Cai, Cheng-Liang Wang, Hsiang-Hsin Chen, Chia-Chi Chien, Sheng-Feng Lai, Yi-Yun Chen, Tzu-En Hua, Ivan M Kempson, Y Hwu*, C S Yang and G Margaritondo, 2010, “Tailored Au nanorods: optimizing functionality, controlling the aspect ratio and increasing biocompatibility”, NANOTECHNOLOGY, 21(33),. (SCIE) (IF: 3.953; SCI ranking: 46.5%,58.2%,31.7%)

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  • [103]     Chia-Chi Chien, C. H. Wang, C. L. Wang, E. R. Li, K. H. Lee, Y. Hwu*, Chien-Yi Lin, Shing-Jyh Chang, C. S. Yang, Cyril Petibois, G. Margaritondo, 2010, “Synchrotron microangiography studies of angiogenesis in mice with microemulsions and gold nanoparticles”, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 397(6), 2109-2116. (SCIE) (IF: 4.478; SCI ranking: 31.6%,25.3%)

  • [104]     Hueywen Liou, Weijen Liou, Hongming Lin*, Yeukuang Hwu, Wenchang Chen, 2010, “Characterization of gold/PMMA hybrid nanomaterials synthesized by hard X-ray synchrotron radiation”, PARTICUOLOGY, 8(3), 234-239. (SCIE) (IF: 3.251; SCI ranking: 50.3%,57.8%)

  • [105]     Cheng-Lung Chen*, Ling-Ru Kuo, Ching-Lin Chang, Yeu-Kuang Hwu, Cheng-Kuang Huang, Shin-Yu Lee, Kowa Chen, Su-Jien Lin, Jing-Duan Huang, Yang-Yuan Chen, 2010, “In situ real-time investigation of cancer cell photothermolysis mediated by excited gold nanorod surface plasmons”, BIOMATERIALS, 31(14), 4104-4112. (SCIE) (IF: 15.304; SCI ranking: 4.1%,6.5%)

  • [106]     Chao-Yu Chung*, Yen-Yin Lin, Kuo-Yu Wu, Wan-Yu Tai, Shi-Wei Chu, Yao-Chang Lee, Yeukuang Hwu, and Yin-Yu Lee, 2010, “Coherent anti-Stokes Raman scattering microscopy using a single-pass picosecond supercontinuum-seeded optical parametric amplifier”, OPTICS EXPRESS, 18(6), 6116-6122. (SCIE) (IF: 3.833; SCI ranking: 27.5%)

  • [107]     B Ankamwar, T C Lai, J H Huang, R S Liu*, M Hsiao, C H Chen and Y K Hwu, 2010, “Biocompatibility of Fe3O4 nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells”, NANOTECHNOLOGY, 21(7). (SCIE) (IF: 3.953; SCI ranking: 46.5%,58.2%,31.7%)

  • [108]     Chi-Jen Liu, Chang-Hai Wang, Shin-Tai Chen, Hsiang-Hsin Chen, Wei-Hua Leng, Chia-Chi Chien, Cheng-Liang Wang, Ivan M Kempson, Y Hwu*, Tsung-Ching Lai, Michael Hsiao, Chung-Shi Yang, Yu-Jen Chen and G Margaritondo, 2010, “Enhancement of cell radiation sensitivity by pegylated gold nanoparticles”, PHYSICS IN MEDICINE AND BIOLOGY, 55(4), 931-945. (SCIE) (IF: 4.174; SCI ranking: 44.9%,36.8%)

  • [109]     Fu-Kuo Huang*, Wen-Chang Chen, Sheng-Feng Lai, Chi-Jen Liu, Cheng-Liang Wang, Chang-Hai Wang, Hsiang-Hsin Chen, Tzu-En Hua, Yi-Yun Cheng, M K Wu, Y Hwu, Chung-Shi Yang and G Margaritondo, 2010, “Enhancement of irradiation effects on cancer cells by cross-linked dextran-coated iron oxide (CLIO) nanoparticles”, PHYSICS IN MEDICINE AND BIOLOGY, 55(2), 469-482. (SCIE) (IF: 4.174; SCI ranking: 44.9%,36.8%)

  • [110]     Kyle N. Grew*, Yong S. Chu, Jaemock Yi, Aldo A. Peracchio, John R. Izzo Jr., Yeukuang Hwu, Francesco De Carlo and Wilson K. S. Chiu, 2010, “Nondestructive Nanoscale 3D Elemental Mapping and Analysis of a Solid Oxide Fuel Cell Anode”, JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 157(6), B783-B792. (SCIE) (IF: 4.371; SCI ranking: 50%,30%)

  • [111]     Shu-Yi Lin*, Fong-Sian Lin, Meng-Kai Chen, Lin-Ren Tsai, Yu-Chen Jao, Hong-Yi Lin, Cheng-Liang Wang, Yeu-Kuang Hwu and Chung-Shi Yang, 2010, “One-pot synthesis of linear-like and photoluminescent polyethylenimines for intracellular imaging and siRNA delivery”, CHEMICAL COMMUNICATIONS, 46(30), 5554-5556. (SCIE) (IF: 6.065; SCI ranking: 29.4%)

  • [112]     Yen-Chih Lin*, Ji-Ming Sun, Jen-Hao Hsiao, Yeukuang Hwu, C. L. Wang, and Tzay-Ming Hong, 2009, “Spontaneous Emergence of Ordered Phases in Crumpled Sheets”, PHYSICAL REVIEW LETTERS, 103(26). (SCIE) (IF: 9.185; SCI ranking: 9.3%)

  • [113]     Yen-Chih Lin*, Ji-Ming Sun, H. W. Yang, Yeukuang Hwu, C. L. Wang, and Tzay-Ming Hong, 2009, “X-ray tomography of a crumpled plastoelastic thin sheet”, PHYSICAL REVIEW E, 80(6). (SCIE) (IF: 2.707; SCI ranking: 47.1%,17.9%)

  • [114]     Chang-Hai Wang, Chi-Jen Liu, Cheng-Liang Wang, Chia-Chi Chien, Y. Hwu*, Ru-Shi Liu, Chung-Shi Yang, Jung-Ho Je, Hong-Ming Lin, G. Margaritondo, 2009, “Intense X-ray induced formation of silver nanoparticles stabilized by biocompatible polymers”, APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 97(2), 295-300. (SCIE) (IF: 2.983; SCI ranking: 60.7%,44.7%)

  • [115]     Chi-Jen Liu, Tsung-Yeh Yang, Chang-Hai Wang, Chia-Chi Chien, Shin-Tai Chen, Cheng-Liang Wang, Wei-Hua Leng, Y. Hwu*, Hong-Ming Lin, Yao-Chang Lee, Chia-Liang Cheng, J.H. Je, G. Margaritondo, 2009, “Enhanced photocatalysis, colloidal stability and cytotoxicity of synchrotron X-ray synthesized Au/TiO2 nanoparticles”, MATERIALS CHEMISTRY AND PHYSICS, 117(1), 74-79. (SCIE) (IF: 4.778; SCI ranking: 36.1%)

  • [116]     B. M. Weon, S. Chang, J. Yeom, S. K. Hahn, J. H. Je*, Y. Hwu, and G. Margaritondo, 2009, “X-ray ablation of hyaluronan hydrogels: Fabrication of three-dimensional microchannel networks”, JOURNAL OF APPLIED PHYSICS, 106(5). (SCIE) (IF: 2.877; SCI ranking: 46%)

  • [117]     Jessie Shiue, Chia-Seng Chang, Sen-Hui Huang, Chih-Hao Hsu, Jin-Sheng Tsai, Wei-Hau Chang, Yi-Min Wu, Yen-Chen Lin, Pai-Chia Kuo, Yang-Shan Huang, Yeukuang Hwu, Ji-Jung Kai, Fan-Gang Tseng and Fu-Rong Chen*, 2009, “Phase TEM for biological imaging utilizing a Boersch electrostatic phase plate: theory and practice”, JOURNAL OF ELECTRON MICROSCOPY, 58(3), 137-145.

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  • [120]     Chi-Jen Liu, Chang-Hai Wang, Cheng-Liang Wang, Y. Hwu*, Chien-Yi Lin, G. Margaritondo, 2009, “Simple dose rate measurements for a very high synchrotron X-ray flux”, JOURNAL OF SYNCHROTRON RADIATION, 16, 395-397. (SCIE) (IF: 2.557; SCI ranking: 46.9%,49%,52.8%)

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  • [122]     Yong Bum Kwon, Byung Mook Weon, Kyu Hwang Won, Jung Ho Je*, Yeukuang Hwu and Giorgio Margaritondo, 2009, “X-ray-Induced Changes in Wettability”, LANGMUIR, 25(4), 1927-1929.

  • [123]     J. T. Kim*, S. K. Seol, J. H. Je, Y. Hwu, and G. Margaritondo , 2009, “The microcontainer shape in electropolymerization on bubbles”, APPLIED PHYSICS LETTERS, 94(3),. (SCIE) (IF: 3.971; SCI ranking: 31.1%)

  • [124]     Yeu-Kuang Hwu, 2008, “Full-field hard x-ray microscopy below 30 nm: a challenging nanofabrication achievement”, NANOTECHNOLOGY, 39(19),395302. (SCIE) (IF: 3.953; SCI ranking: 46.5%,58.2%,31.7%)

  • [125]     胡宇光, 2006, “Silicified egg clusters from a Middle Cambrian Burgess Shale–type deposit, Guizhou, south China”, Geology, 34(12), 1037-1040. (SCIE) (IF: 6.324; SCI ranking: 2%)

  • [126]     胡宇光, 2006, “Synchrotron X-ray synthesis of colloidal gold particles for drug delivery”, Materials Chemistry and Physics, 100, 72-76.

  • [127]     胡宇光, 2006, “X-ray synthesis of nickel–gold composite nanoparticles”, Materials Chemistry and Physics, 100, 292-295. (SCIE) (IF: 4.778; SCI ranking: 36.1%)

  • [128]     胡宇光, 2006, “Field dependence of spin and orbital moments of Fe in L10 FePt magnetic thin films”, Journal of Magnetism and Magnetic Materials, 303, 247-250. (SCIE) (IF: 3.097; SCI ranking: 59.5%,50.7%)

  • [129]     胡宇光, 2006, “Phase contrast radiography of Lewy bodies in Parkinson disease”, Neuroimage, 32(2), 566-569. (SCIE) (IF: 7.4; SCI ranking: 14.3%,13.8%,11%)

  • [130]     胡宇光, 2006, ““In vivo real-time vessel Imaging and ex vivo 3D reconstruction of atherosclerotic plaque”, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 47(4), 330-331. (SCIE) (IF: 27.206; SCI ranking: 3.5%)

  • [131]     胡宇光, 2006, ““Phosphatized Polar-lobe-Forming Embryos from the Precambrian of Southwest China”, Science, 312, 1644-1646. (SCIE) (IF: 63.832; SCI ranking: 2.7%)

  • [132]     胡宇光, 2006, “Spin and Orbital Magnetic Moments of FePt Thin Films”, Jpn. J. Appl. Phys, 45(4A), 2539-2541. (SCIE) (IF: 1.491; SCI ranking: 80.1%)

  • [133]     胡宇光, 2006, “Investigation of phase miscibility of CoCrPt thin films using anomalous x-ray scattering and extended x-ray absorption fine structure”, Appl. Phys. Lett, 88, 32767.

  • [134]     胡宇光, 2006, “Study of effects of annealing on nanostructured Co–C thin films by X-ray absorption spectroscopy”, Journal of Magnetism and Magnetic Materials, 303, 383-386.

  • [135]     胡宇光, 2006, “From K atom pairs to K atomic chains: A semiconducting 2x3 to metallic 2x1 transition on the ?-SiC(100) c(4x2) surface”, Appl. Phys. Lett, 88, 22105. (SCIE) (IF: 3.971; SCI ranking: 31.1%)

  • [136]     胡宇光, 2006, “Phase contrast x-ray imaging”, International Journal of Nanotechnology (Invited Review Paper), 3(2/3), 280-297.

  • [137]     胡宇光, 2006, ““Synchrotron microradiography study on acute lung injury of mouse caused by PM(2.5) aerosols”, Eur. J. Radiol, 58(2), 266-272.

  • [138]     Hwu Y, Je JH and Margaritondo G, 2005, “Real-time radiology in the microscale”, NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 551(1), 108-118. (SCIE) (IF: 1.335; SCI ranking: 81.3%,67.6%,78.9%,82.8%)

  • [139]     Seol SK, Pyun AR and Hwu YK et al., 2005, “Localized electrochemical deposition of copper monitored using real-time X-ray microradiography”, ADVANCED FUNCTIONAL MATERIALS, 15(6), 934-937. (SCIE) (IF: 19.924; SCI ranking: 5.6%,6.1%,4.9%,7.3%,5%,8.7%)

  • [140]     Hwu Y, Je JH and Margaritondo G, 2005, “Real-time radiology in the microscale”, CHINESE JOURNAL OF PHYSICS, 43((1): Part 2), 285-292. (SCIE) (IF: 3.957; SCI ranking: 30.2%)

  • [141]     Hwu Y, Tsai WL and Chang HM et al., 2004, “Imaging cells and tissues with refractive index radiology”, BIOPHYSICAL JOURNAL, 87(6), 4180-4187. (SCIE) (IF: 3.699; SCI ranking: 41.7%)

  • [142]     Meuli R, Hwu Y and Je JH et al., 2004, “Synchrotron radiation in radiology: radiology techniques based on synchrotron sources”, EUROPEAN RADIOLOGY, 14(9), 1550-1560. (SCIE) (IF: 7.034; SCI ranking: 14.7%)

  • [143]     Hwu Y, Tsai WL and Je JH et al., 2004, “Synchrotron microangiography with no contrast agent”, PHYSICS IN MEDICINE AND BIOLOGY, 49(4), 501-508. (SCIE) (IF: 4.174; SCI ranking: 44.9%,36.8%)

  • [144]     Margaritondo G, Hwu Y and Je JH, 2004, “Synchrotron light in medical and materials science radiology”, RIVISTA DEL NUOVO CIMENTO, 27(7), 1-40. (SCIE) (IF: 3.609; SCI ranking: 39.5%)

  • [145]     Tsai WL, Hsu PC and Hwu Y et al., 2003, “Edge-enhanced radiology with broadband synchrotron X-rays”, NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 199, 436-440. (SCIE) (IF: 1.279; SCI ranking: 84.4%,70.6%,88.9%,84.2%)

  • [146]     Tsai WL, Hwu Y and Chen CH et al., 2003, “Grain boundary imaging, gallium diffusion and the fracture behavior of Al-Zn Alloy - An in situ study”, NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 199, 457-463. (SCIE) (IF: 1.279; SCI ranking: 84.4%,70.6%,88.9%,84.2%)

  • [147]     Tsai WL, Hsu PC and Hwu Y et al., 2003, “Real-time observation of Zn electro-deposition with high-resolution microradiology”, NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 199, 451-456. (SCIE) (IF: 1.279; SCI ranking: 84.4%,70.6%,88.9%,84.2%)

  • [148]     Lee HJ, Je JH and Hwu Y et al., 2003, “Synchrotron X-ray induced solution precipitation of nanoparticles”, NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 199, 342-347. (SCIE) (IF: 1.279; SCI ranking: 84.4%,70.6%,88.9%,84.2%)

  • [149]     Fecher GH, Schmidt O and Hwu Y et al., 2002, “Multiphoton photoemission electron microscopy using femtosecond laser radiation”, JOURNAL OF ELECTRON SPECTROSCOPY AND RELATED PHENOMENA, 126(1-3), 77-87. (SCIE) (IF: 1.993; SCI ranking: 58.1%)

發現與突破

  • [1]     西元年：2018
    研究人員(中)：胡宇光、黃啟峰、梁耕三、徐翠玲、李宗澤、陳怡云、楊舜閔、陳翔欣、黃士炘 章為皓 李定國 陳培菱、彭奎恩、陳健群、Cheng-Zhi Shi、胡宇方、Giorgio Margaritondo、翁啟惠、胡宇光
    研究人員(英)：HWU, YEU-KUANG, Chi-Feng Huang, Keng S. Liang, Tsui-Ling Hsu, Tsung-Tse Lee, Yi-Yun Chen, Shun-Min Yang, Hsiang-Hsin Chen, Shih-Hsin Huang, Wei-Hau Chang, Ting-Kuo Lee, Peilin Chen, Kuei-En Peng, Chien-Chun Chen, Cheng-Zhi Shi, Yu-Fang Hu, Giorgio Margaritondo, Tetsuya Ishikawa, Chi-Huey Wong and Y. Hwu*
    研究成果名稱(中)：以自由電子雷射同調繞射影像術解析水溶液中攜帶藥物之微脂體影像
    研究成果名稱(英)：Free-Electron-Laser Coherent Diffraction Images Individual Drug-Carrying Liposome Particles in Solution
    簡要記述(中)：微脂體是由脂質所組成，臨床上，許多廣泛性的抗癌藥物便是利用微脂體進行輸送。改變微脂體的大小及性質，對於醫療應用及社會貢獻度將具有相當價值。然而目前的成像方法要在天然的液體環境中，評估脂質體的形狀及尺寸具有相當的難度。X光自由電子雷射術(X-FEL)的發展，對於具有較大尺寸的金屬奈米粒子和病毒的影像特別有幫助。我們將包覆有doxorubicin之微脂體進行X-FEL照射後，取得影像以 CDI進行演算及重組，重組影像與低溫電子顯微鏡（Cyro-EM）所得到的影像或經由X光小角度散射(SAXS)分析所得的散斑圖案結果一致。然而值得注意的是，低溫電子顯微鏡並無法觀測在一般液態環境中的微脂體。而常規的SAXS無法偵測在水溶液中偵測非均質性及大小不均勻的奈米棒狀樣品。特別的是這些搭載藥物的奈米顆粒其典型結構是具特異性的並且大小不均勻。這樣的特性也會影響其他成像技術：例如，動態光散射儀，其測得平均值遠超過許多顆粒大小，同時也無法檢測奈米顆粒內的藥物。我們顯示了X-FEL結合CDI可以克服這些限制，並得到微脂體包覆藥物在水溶液中的影像。該方法可望做為日後，藥廠對於同類型藥物於水溶液中型態分析之方法。
    簡要記述(英)：Using the excellent performances of the SACLA (RIKEN/HARIMA, Japan) X-ray free electron laser (X-FEL), coherent diffraction imaging (CDI) was used to detect individual liposome particles in water, with or without inserted doxorubicin nanorods. This was possible because of the electron density differences between the carrier, the liposome, and the drug. The result is important since liposome nanocarriers dominate at present the drug delivery systems. In spite of the low cross section of the original ingredients, the diffracted intensity of drug-free liposomes was sufficient for spatial reconstruction yielding quantitative structural information. For particles containing doxorubicin, the structural parameters of the nanorods could be extracted from CDI. Furthermore, the measurement of the electron density of the solution enclosed in each liposome provides direct evidence of the incorporation of ammonium sulphate into the nanorods. Overall, ours is an important test for extending the X-FEL analysis of individual nanoparticles to low cross-section-systems in solution, and also for its potential use to optimize the manufacturing of drug nanocarriers. The complete results have been published in the Nanoscale.


  • [2]     西元年：2017
    研究人員(中)：胡宇光、裴熙理、陳祥欣、NanoX 團隊(台灣)、INSERM 團隊(法國)
    研究人員(英)：HWU, YEU-KUANG, CYRIL PETIBOIS, Hsiang-Hsin Chen, NanoX group, INSERM (France)
    研究成果名稱(中)：利用定量遠紅外線顯微鏡構築全腦三維化學影像
    研究成果名稱(英)：3D chemical imaging of the brain using quantitative IR spectro-microscopy
    簡要記述(中)：三維組織學技術的建立是現代解剖病理學發展的當務之急。辨識組織中不正常的因子對於了解疾病發生原因是必須的。然而目前並沒有可以在體內或組織裡用以偵測這些不正常因子，並將其以高解析度的三維影像呈現出來的技術。本所客座專家裴熙理博士與胡宇光研究員團隊應用一具有獨特性且具高通量的遠紅外線顯微術進行組織病理學之研究，該技術可結合自動圖像校正及三維-遠紅外線(3D-IR)圖像的光譜數據分析加以重建。該團隊成功的將370片小鼠全腦之連續切片，進行全光譜3D-IR影像掃描後得到腦腫瘤內部精確的化學成分組成並加以圖像化，同時亦經由X光斷層掃描技術進一步確認該腫瘤在腦部的位置。3D-IR圖譜的建立，可利用解剖學、化學及代謝產物之資訊，將腫瘤組織於正常大腦區塊中辨識出來。該團隊亦證實組織的代謝參數可以從IR的光譜圖中取得、定量，其代謝特徵可做為正常腦組織與腫瘤間的區別，同時也可以印證腫瘤組織中的瓦氏效應。該團隊所建立的光譜學方法，可以經由搜索整個光譜分佈，進一步以非監控的方式來區分腫瘤與健康組織。詳細的結果已發表於Chemical Science。
    簡要記述(英)：Characterizing abnormal parameters in a tissue is essential to understand the rationale of pathology development. However, there is no analytical technique, in vivo or histological, able to discover such abnormal features and provide their 3D distribution at microscopic resolution. Here, we introduce a unique high-throughput infrared (IR) microscopy method, which combines automated image corrections and subsequent spectral data analysis for 3D-IR image reconstruction. We performed the spectral analysis of a complete organ for a small animal model, a mouse brain with an implanted glioma tumor. The 3D-IR image is reconstructed from 370 consecutive tissue sections and corrected with the X-ray tomogram of the organ for an accurate quantitative analysis of chemical contents. A 3D matrix of 89.106 IR spectra is generated, allowing to separate the tumor mass from healthy brain tissues based on various anatomical, chemical, and metabolic parameters. We demonstrate that quantitative metabolic parameters can be extracted from IR spectra for characterization of brain vs. tumor metabolism (assessing the Warburg effect in tumor). Our method can be further exploited by searching for whole spectral profile discriminating tumor vs. healthy tissue in a non-supervised manner, which we call ‘spectromics’. The complete results have been published in the Chemical Science.
    主要相關著作：
    Abiodun Ogunleke, Benoit Recur, Hugo Balacey, Hsiang-Hsin Chen, Maylis Delugin, Yeukuang Hwu, Sophie Javerzat, Cyril Petibois*, 2018, “3D chemical imaging of the brain using quantitative IR spectro-microscopy.”, CHEMICAL SCIENCE, 9(1), 189-198. (SCIE) (IF: 9.969; SCI ranking: 13.9%)


  • [3]     西元年：2014
    研究人員(中)：胡宇光、蔡岳霖、李家維、洪在明、
    研究人員(英)：HWU, YEU-KUANG, Yueh-Lin Tsai, Chia-Wei li, Tzay-Ming Hong, Jen-Zon Ho, En-Cheng Yang, Wen-Yen Wu, G. Margaritondo, Su-Ting Hsu, Edwin B. L. Ong and Y. Hwu
    研究成果名稱(中)：利用X光三維成像技術解析螢火蟲發光之物理機制
    研究成果名稱(英)：X-ray 3D imaging elucidates firefly luminescence physical mechanism
    簡要記述(中)：中央研究院物理研究所NanoX研究團隊成功利用同步輻射X光顯微鏡觀測螢火蟲發光器的氣管系統並解析出螢火蟲控制螢光閃爍的物理機制。
    幾千年以來，螢火蟲產生自發的螢光的現象，不斷吸引人類的幻想。螢光蛋白及酵素也早已被分離、萃取、合成，並產生了大量的應用。但是不同於其他可以自發產生螢光之生物體螢火蟲可以控制螢光的發光，進而利用螢光的閃爍，達到群體聯繫的目的。螢火蟲控制螢光閃爍的生化機制也是於最近幾年才被提出，認為一氧化氮與粒線體的作用，作為細胞層級開關的角色。但是在系統層面及氧氣供應機制方面這些研究並沒有清楚的圖像。而當螢火蟲發光時，其發光器內複雜的氣管系統藉由與氣孔與外界直接連結，利用氣體的擴散經微小的氣管，將氧氣輸送到螢火蟲體內的發光細胞中，並利用發光細胞裡的螢光酵素將螢光素及氧氣結合，使得螢光素因為氧化而激發出螢光。並且在氧氣消耗殆盡之後再度回覆穩態。因為螢光發光時氧氣的供應是唯一可被調控而造成閃爍的反應要件，所以其在完整生物系統所扮演的角色，不應只嘗試在細胞生化層面回答。
    傳統生物學觀察方式，因為無法對活體昆蟲進行超過光學解析度的即時影像分析，因此無法斷定數種有關氧氣供應方式的假說。中央研究院物理研究所NanoX研究團隊此次利用我國國家同步輻射研究中心之高亮度X光，藉由X光顯微成像之高穿透力及三維奈米解析度，成功地對螢火蟲發光器進行了完整的三維顯微成像，包括螢火蟲的體內極為複雜的微氣管結構，以及直徑小於200奈米之支氣管。經過數值化處理所有的氣管系統後，我們可以精確地計算出氧氣到達發光細胞的流量，並藉由精確地測量螢光發光的能量消耗評估氧氣提供螢光發光的整體效率。
    基於以證實之螢光持續的時間與粒線體的關聯，我們可以證實在正常代謝狀況時，粒線體將消耗所有氣管系統所提供之氧氣，完全阻隔氧氣進入發光細胞中的發光系統。因此螢光閃爍頻率的控制需藉由粒線體的鈍化來達成。例如藉由一氧化氮合酶（NOS）受到神經系統刺激產生快速擴散的一氧化氮與粒線體的生化結合，鈍化粒線體來造成發光系統可以得到足夠的氧氣供給發出螢光。一氧化氮與粒線體的生化結合極為短暫，一氧化氮消逝而粒線體消耗氧氣速率高於氧氣從氣管系統到發光細胞的擴散速率時，螢光素將會因為缺乏氧氣而逐漸回復穩態，並停止發光。此種中間歇性的氧氣供給，也就是造成可控制的螢光的閃爍現象。
    此突破性的研究成果是由清華大學李家維教授、中央研究院物理研究所胡宇光研究員，與瑞士EPFL、特有生物保育中心、台灣大學國立臺灣大學昆蟲學系合作所共同完成，並發表於國際知名物理期刊(Phys. Rev. Lett. 2014, DOI: 10.1103/physrevlett.113.258103)

    簡要記述(英)：The Institute of Physics NanoX team has resolved an important physical phenomenon in firefly luminescence mechanism using bright synchrotron x-rays of National Synchrotron Radiation Research Center and the phase contrast microtomography and transmission x-ray microscopy with spatial resolution <20nm.
    Firefly luminescence occurs through the action of the enzyme luciferase, which combines luciferin and oxygen to make oxyluciferin in an electronically excited state and releases light as it relaxes.
    While its biochemistry background was only recently established, the physical aspect remains unclear specifically where oxygen supply mechanism for light flashing is concerned.
    The team resolved this problem by obtaining a detailed three-dimensional mapping of the firefly lantern – a complex microscopic structure of the tracheal system including the smallest tracheole branches (~200 nm diameter) critical for the gas exchange.
    They established that the oxygen consumption corresponding to mitochondria functions exceeds the maximum rate of oxygen diffusion from the tracheal system to the photocytes and leave no room for other hypothesized control mechanisms to waste the oxygen supply.
    Measurement of the energy consumption of flashing confirms that the flashing mechanism indeed uses a large portion of this maximum rate. The flashing control therefore requires the mitochondria functions, which is also require large oxygen supply, to be passivated, e.g., by nitric oxide, subsequently allowing the oxygen supply to be switched to photoluminescence.
    This groundbreaking research was led by Chia-Wei Li of National Tsing Hua University and Yeu-Kuang Hwu of Academia Sinica, in collaboration with the Swiss Institution EPFL (Phys. Rev. Lett. 2014, DOI: 10.1103/physrevlett.113.258103).

    主要相關著作：
    Yueh-Lin Tsai, Chia-Wei Li,* Tzay-Ming Hong, Jen-Zon Ho, En-Cheng Yang, Wen-Yen Wu,G. Margaritondo, Su-Ting Hsu, Edwin B. L. Ong, and Y. Hwu, 2014, “Firefly Light Flashing: Oxygen Supply Mechanism”, PHYSICAL REVIEW LETTERS, 113, 258103. (SCIE) (IF: 9.185; SCI ranking: 9.3%)


  • [4]     西元年：2004
    研究人員(中)：胡宇光
    研究人員(英)：HWU, YEU-KUANG
    研究成果名稱(英)：Real time high resolution X-ray microscopy observa
    簡要記述(中)：高解析、高速度之x光顯像術具有即時觀察電鍍鍍膜之成長能力。藉由此項優勢，我們成功的觀察到過去從未在電鍍時發現到的之現象，那就是金屬鍍膜將在非導電的水汽泡表面上成長(如圖1所示)。這項發現不只說明了水汽泡在這個特殊情況下具有導電性，而且也提供了充分的證據說明當電鍍未達到最佳化時缺陷之生成機制，這項發現已在2002年的”自然”雜誌中發表。我們亦用相同的成像機制觀察高速之活體動物影像，在2004年中的”自然”雜誌中亦發表了此項特殊成果。圖2顯示胚胎群分裂之化石結構的3維重組影像，此非破壞性之技術且同時具備高解析度三維影像之能力可用來鑑定特殊細胞分裂模式，此種特殊的細胞分化型式在5億4仟萬年前就已存在。

    簡要記述(英)：High resolution, high speed radiology allows us to monitor the electrodeposition process in real time and realistic electrochemical environment. The discovery of a special growth phenomenon demonstrated the first time that metal deposition can occur on the seemingly nonconducting hydrogen bubbles.(Fig. 1) This observation does not only prove that the hydrogen bubble surface in this case is conducting, but also provide evidence of the nature of one notorious type of defects often compromises the film quality in electrodeposition. This work was published in Nature 2002. Our work using similar approach in high speed animal imaging was also reported by Nature in 2004. Fig. 2 show the tomography reconstructed 3D model of a fossil embryo cluster frozen in time exactly at a 2-4 fold cell cleavage stage. The nondestructive high resolution 3D imaging allows us to identify the special division mode in cell and prove that such type of cell differentiation already existed 540 million years ago.



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