338
27896704
thiraiwa [at] gate.sinica.edu.tw
Hiraiwa, Tetsuya / Associate Research Fellow
Contact Information
Education
Secretary
Rao, Cindy / 886-2-2789-8916
cindy14 [at] gate.sinica.edu.tw
Research Interest
- Theoretical Biological Physics, Softmatter Physics and Out-of-Equillibrium Physics
- Mechanobiology
Experience
Research Achievements
Journal Papers
- [1] M. Mukenhirn, C.-H. Wang, T. Guyomar, M. J. Bovyn, M. F. Staddon, R. Maraspini, L. Lu, C. Martin-Lemaitre, M. Sano, T. Hiraiwa, D. Riveline*, A. Honigmann*, 2024, “Tight junctions regulate lumen morphology via hydrostatic pressure and junctional tension.”, DEVELOPMENTAL CELL, 59, 2866.
- [2] R. Das*, T. Sakaue, G.V. Shivashankar, J. Prost*, T. Hiraiwa*, 2024, “Transient-linking activity enhances subnuclear dynamics by affecting chromatin remodeling.”, PHYSICAL REVIEW LETTERS, 132, 058401.
- [3] Delanoë-Ayari Hélène, Hiraiwa Tetsuya, Marcq Philippe, Rieu Jean-Paul, Saw Thuan Beng, 2023, “2.5D Traction Force Microscopy: Imaging three-dimensional cell forces at interfaces and biological applications”, The International Journal of Biochemistry & Cell Biology, 161, 106432.
- [4] HIRAIWA Tetsuya, 2023, “Computer Simulations of Dynamic Self-organization of Migrating Cells”(遊走細胞集団の動的自己組織化についての数理モデルと数値シミュレーション), Seibutsu Butsuri, 63(4), 207-211.
發現與突破
- [1] 西元年：2024
研究人員(中)：平岩徹也
研究人員(英)：HIRAIWA, TETSUYA
研究成果名稱(中)：分子的機械作用如何影響活細胞中染色質的波動動力學的計算研究
研究成果名稱(英)：Computational study on how mechanical action of molecules influences fluctuating dynamics in the chromatin in a living cell
簡要記述(中)：真核細胞的遺傳信息存儲在其染色質中，染色質是一種類似聚合物的實體，由DNA和組蛋白組成，密集地包裝 在細胞核內。細胞核還包含各種亞核區，其相對於染色質的時空協調被認為是決定基因表達的重要因素。同時，在 活體細胞中，為實現細胞功能，各種其他亞核分子如酶(如聚合酶和拓撲異構酶)應該在起作用，而這些作用分子對 染色質中亞核區的波動動態可能會產生機械干擾。由本所平岩徹也博士(曾任新加坡國立大學 Mechanobiology Institute)和Jacques Prost博士(Curie Institute，巴黎)領導的國際合作團隊數值上證明了某些類型的干擾確實增強了複 雜的聚合物介質(用以模擬染色質)中的粒子(用以模擬亞核區)的波動。他們還澄清了這種波動動態可以通過三種動態模 式的組合有效地描述，其中包括一種與聚合網格的動態重構相關的新發現模式。這一洞察提供了一個新的視角，說明 了分子的機械干擾如何通過調節亞核區聚動態來調控基因表達。完整的研究資料已發表於Physical Review Letters, Vol. 132, 058401 (2024)。
簡要記述(英)：Genetic information of a eukaryotic cell is stored in its chromatin, a polymer-like entity comprising DNA and histone proteins, densely packed inside the nucleus. The nucleus also contains varieties of subnuclear compartments, whose spatiotemporal coordination relative to the chromatin is known to be an important factor determining the gene expressions. Meanwhile, in a living cell, various other subnuclear molecules like enzymes (such as polymerases and topoisomerases) should be acting to achieve cellular functions, and the mechanical perturbation by such acting molecules may affect fluctuating dynamics of subnuclear compartments in the chromatin. The international collaboration team led by Dr. Tetsuya Hiraiwa (IoPAS, and formerly Mechanobiology Institute in Singapore) and Dr. Jacques Prost (Curie Institute in Paris) numerically demonstrated that some classes of perturbations indeed enhance the fluctuation of the particles (mimicking the subnuclear compartments) within the complex polymeric medium (mimicking chromatin). They also clarified that this fluctuating dynamics can be effectively described by a combination of three dynamical modes, including a newly-discovered mode associated with the dynamic reconfigurations of polymeric meshes. This insight provides a fresh perspective on how mechanical perturbation of molecules may govern gene expressions by regulating the subnuclear-compartment dynamics. The complete work has been published recently on Physical Review Letters, Vol. 132, 058401 (2024).主要相關著作： R. Das*, T. Sakaue, G.V. Shivashankar, J. Prost*, T. Hiraiwa*, 2024, “Transient-linking activity enhances subnuclear dynamics by affecting chromatin remodeling.”, PHYSICAL REVIEW LETTERS, 132, 058401.