郭青齡 / 副研究員

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連絡資訊

學歷

  • B.S., National Taiwan University, 1994; M.S., 1996; Ph.D., University of California (San Diego)

秘書

李馥芳 / 886-2-2789-8985

fiona[at]phys.sinica.edu.tw

研究興趣

  • cellular mechanisms of self-organization in biological systems, the biomechanics that enhance and stabilize spatiotemporal control

經歷

  • 2001. Assistant Professor, 2006-14; Caltech, 2014

研究成果

期刊論文

  • [1]     Szu-Yin Ho, Che-Mai Chang, Hsin-Ni Liao, Wan-Hsuan Chou, Chin-Lin Guo, Yun Yen, Yusuke Nakamura, Wei-Chiao Chang, accepted, “Current Trends in Neoantigen-Based Cancer Vaccines”, PHARMACEUTICALS. (SCIE) (IF: 4.8; SCI ranking: 25%,18.9%)

  • [2]     Syue-Wei Peng, Mai-Huong T Ngo, Yung-Che Kuo, Ming-Hao Teng, Chin-Lin Guo, Hung-Cheng Lai, Te-Sheng Chang, Yen-Hua Huang, 2023, “Niclosamide Revitalizes Sorafenib through Insulin-Like Growth Factor 1 Receptor (IGF-1R)/Stemness and Metabolic Changes in Hepatocellular Carcinoma”, cancers, 15(3), 931, 931. (SCIE) (IF: 4.4; SCI ranking: 32.8%)

  • [3]     Chen Lu-Chun, Nersisyan Stepan, Wu Chang-Jiun, Chang Che-Mai, Tonevitsky Alexander, Guo Chin-Lin, Chang Wei-Chiao, 2022, “On the peptide binding affinity changes in population-specific HLA repertoires to the SARS-CoV-2 variants Delta and Omicron”, Journal of Autoimmunity, 133, 102952. (SCIE) (IF: 7; SCI ranking: 15.1%)

  • [4]     Chen Jia-Yang, Chou Hsu-Huan, Lim Syer Choon, Huang Yen-Jang, Lai Kuan-Chen, Guo Chin-Lin, Tung Chien-Yi, Su Chung-Tsai, Wang Jocelyn, Liu Edward, Han Hsiao-Fen, Yeh Po-Ying, Hu Chun-Mei, Dunn Alexander R., Frank Curtis W., Wu Yi-Chun, Yang Muh-Hwa, Chang Ying-Chih, 2022, “Multiomic characterization and drug testing establish circulating tumor cells as an ex vivo tool for personalized medicine”, iScience, 25(10), 105081. (SCIE) (IF: 4.1; SCI ranking: 25.7%)

  • [5]     Guo Chin-Lin, 2022, “Self-Sustained Regulation or Self-Perpetuating Dysregulation: ROS-dependent HIF-YAP-Notch Signaling as a Double-Edged Sword on Stem Cell Physiology and Tumorigenesis”, Frontiers in Cell and Developmental Biology, 10, 862791. (SCIE) (IF: 4.3; SCI ranking: 39.7%,13.2%)

  • [6]     Guo Chinlin, Chang Wei-Chiao, 2021, “Modeling-Based Estimate of the Vaccination Rate, Lockdown Rules and COVID-19”, Healthcare, 9(10), 1245. (SCIE, SSCI) (IF: 2.7; SCI ranking: 46.3%; SSCI ranking: 36.4%)

  • [7]     Au Heng-Kien, Peng Syue-Wei, Guo Chin-Lin, Lin Chien-Chia, Wang Yi-Lin, Kuo Yung-Che, Law Tsz-Yau, Ho Hong-Nerng, Ling Thai-Yen, Huang Yen-Hua, 2021, “Niche Laminin and IGF-1 Additively Coordinate the Maintenance of Oct-4 Through CD49f/IGF-1R-Hif-2α Feedforward Loop in Mouse Germline Stem Cells”, Frontiers in Cell and Developmental Biology, 9, 646644. (SCIE) (IF: 4.3; SCI ranking: 39.7%,13.2%)

  • [8]     Ouyang Mingxing, Yu Jiun‐Yann, Chen Yenyu, Deng Linhong, Guo Chin‐Lin, 2021, “Cell‐extracellular matrix interactions in the fluidic phase direct the topology and polarity of self‐organized epithelial structures”, Cell Proliferation, 54(4), e13014. (SCIE) (IF: 5.6; SCI ranking: 28%)

  • [9]     Wong Henry Sung-Ching, Guo Chin-Lin, Lin Gan-Hong, Lee Kang-Yun, Okada Yukinori, Chang Wei-Chiao, 2021, “Transcriptome network analyses in human coronavirus infections suggest a rational use of immunomodulatory drugs for COVID-19 therapy”, Genomics, 113(2), 564-575. (SCIE) (IF: 3; SCI ranking: 47.4%,38.5%)

  • [10]     Chih-Yu Wu, Chin-Lin Guo, Yen-Ching Yang, Chao-Wei Huang, Jun-Yu Zeng, Zhen-Yu Guan, Yu-Chih Chiang, Peng-Yuan Wang, Hsien-Yeh Chen, 2020, “Parylene-Based Porous Scaffold with Functionalized Encapsulation of PRP and Living Stem Cells for Tissue Engineering Applications”, ACS Appl. Bio Mater., 3(10), 7193-7201.

  • [11]     Wu MF, Lin CA, Yuan TH, Yeh HY, Su SF, Guo CL, Chang GC, Li KC, Ho CC, Chen HW, 2020, “The M1/M2 Spectrum and Plasticity of Malignant Pleural Effusion-Macrophage in Advanced Lung Cancer”, CANCER IMMUNOLOGY IMMUNOTHERAPY, 70(5), 1435--1450. (SCIE) (IF: 5.1; SCI ranking: 26.4%,26.1%)

  • [12]     Tsai, Y. L. Yeh, P. Y. Huang, C. J. Guo*, C. L. Chang, Y. C., 2019, “Scalable Multilayer Cell Collector to Capture Circulating Tumor Cells with an Unlimited Volume Capacity”, ACS BIOMATERIALS SCIENCE & ENGINEERING, 5(6), 2725-2731. (SCIE) (IF: 5.5; SCI ranking: 38.1%)

  • [13]     J-Y. Yu, S. Kim, D. B. Holland, M. A. Allodi, G. A. Blake, Y-G. Han and C. Guo, 2018, “Fiber-array illumination: realizing high temporal multiplexing in multifocal multiphoton microscopy with simplicity”, Scientific Reports, 8(1),14863. (SCIE) (IF: 3.9; SCI ranking: 29.7%)

  • [14]     Yu, J. Y. Kim, J. Holland, D. B. Mou, Y. Chiu, H. Blake, G. A. Lee, W. Guo, C. L., 2018, “Multiphoton structured thin-plane imaging with a single optical path”, OPTICS LETTERS, 43(21),5271-5274. (SCIE, EI) (IF: 3.3; SCI ranking: 34.3%)

  • [15]     G-Y. Zhuo, M-Y. Chen, C-Y. Yeh, J-Y. Yu, C Guo, and F-J. Kao., 2017, “Fast determination of three­dimensional fibril orientation of type­I collagen via macroscopic chirality”, APPLIED PHYSICS LETTERS, 110, 023702. (SCIE) (IF: 3.6; SCI ranking: 35.4%)

  • [16]     T-Y. Chang, C. Chen, Y-C. Chang, C-H. Lu, M. Lee, S-T. Lu, D-Y. Wang, A. Wang, C. Guo and P-L. Cheng, 2017, “Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery”, ELIFE. (SCIE) (IF: 6.4; SCI ranking: 8.9%)

  • [17]     Muller, N. Piel, M. Calvez, V. Voituriez, R. Goncalves-Sa, J. Guo, C. L. Jiang, X. Murray, A. Meunier, N, 2016, “A Predictive Model for Yeast Cell Polarization in Pheromone Gradients”, PLoS Computational Biology, 12(4), e1004795. (SCIE) (IF: 3.6; SCI ranking: 29.9%,20.4%)

  • [18]     Meng-Tsung Hsu, Chin-Lin Guo, Angela Y. Liou, Ting-Ya Chang, Ming-Chong Ng, Yen-Lin Wu, Bogdab I. Florea, Herman S. Overkleeft, Yen-Ling Wu, Jung-Chi Liao, and Pei-Lin Cheng , 2015, “Stage-Dependent Axon transport of Proteasomes Contributes to Axon Development ”, Developmental Cell, in press. (SCIE) (IF: 8.7; SCI ranking: 15.9%,5.3%)

  • [19]     Mou Y, Yu JY, Wannier TM, Guo CL, Mayo SL, 2015, “Computational design of co-assembling protein-DNA nanowires.”, Nature, 525(7568), 230-3. (SCIE) (IF: 48.5; SCI ranking: 2.7%)

  • [20]     Guo CL, Cheng PL, 2015, “Second messenger signaling for neuronal polarization: cell mechanics-dependent pattern formation.”, Developmental neurobiology, 75(4), 388-401. (SCIE) (IF: 2.3; SCI ranking: 44.7%,70.1%)

  • [21]     Abrams MJ, Basinger T, Yuan W, Guo CL, Goentoro L, 2015, “Self-repairing symmetry in jellyfish through mechanically driven reorganization.”, Proceedings of the National Academy of Sciences of the United States of America, 112(26), E3365-73. (SCIE) (IF: 9.1; SCI ranking: 16.2%)

  • [22]     Guo CL, 2013, “Mechanical models for the self-organization of tubular patterns.”, Biomatter, 3(3).

  • [23]     Guo CL, Harris NC, Wijeratne SS, Frey EW, Kiang CH, 2013, “Multiscale mechanobiology: mechanics at the molecular, cellular, and tissue levels.”, Cell & bioscience, 3(1), 25. (SCIE) (IF: 6.2; SCI ranking: 16.9%)

  • [24]     J-Y. Yu, D. B. Holland, G. A. Blake, and C. Guo, 2013, “The wide Field optical sectioning of a microlens array and structural illumination-based plane-projection multi-photon microscopy”, OPTICS EXPRESS, 21, 2097-109. (SCIE) (IF: 3.3; SCI ranking: 34.3%)

  • [25]     Guo CL, Ouyang M, Yu JY, Maslov J, Price A, Shen CY, 2012, “Long-range mechanical force enables self-assembly of epithelial tubular patterns.”, Proceedings of the National Academy of Sciences of the United States of America, 109(15), 5576-82. (SCIE) (IF: 9.1; SCI ranking: 16.2%)

  • [26]     A. Grosberg, P-L. Kuo, C. Guo, N. A. Geisse, M-A. Bray, W. J. Adams, S. P. Sheehy, and K. K. Parker, 2011, “Self-organization of muscle cell structure and function”, PLoS Computational Biology, 7:e1001088. (SCIE) (IF: 3.6; SCI ranking: 29.9%,20.4%)

  • [27]     J-Y. Yu, C-H. Kuo, D. B. Holland, Y-Y. Chen, M. Ouyang, G. A. Blake, R. Zadoyan, and C. Guo, 2011, “Wide-field optical sectioning for live-tissue imaging by plane-projection multi-photon microscopy”, JOURNAL OF BIOMEDICAL OPTICS, 16, 116009. (SCIE) (IF: 2.9; SCI ranking: 44.2%,43.4%,40.4%)

  • [28]     Z. Chang, C. Guo, I. Ahronowitz, A. O. Stemmer-Rachamimov, M. MacCollin, F. P. Nunes, 2009, “A role for the p53 pathway in the pathology of meningiomas with NF2 loss. Journal of Neuro-oncology”, JOURNAL OF NEURO-ONCOLOGY, 9, 265-270. (SCIE) (IF: 3.1; SCI ranking: 41%,51.5%)

  • [29]     P-W. Fok, C. Guo, and T. Chou, 2008, “Guanine-mediated adsorption of DNA repair proteins”, JOURNAL OF CHEMICAL PHYSICS, 129, 235101. (SCIE) (IF: 3.1; SCI ranking: 55.8%,28.6%)

  • [30]     Mechanisms underlying sequence independent beta-sheet formation, 2002, “C. Guo, M. Cheung, D.A. Kessler, and H Levine”, JOURNAL OF CHEMICAL PHYSICS, 116, 4353-4365. (SCIE) (IF: 3.1; SCI ranking: 55.8%,28.6%)

  • [31]     C. Guo and H. Levine, 2000, “A statistical mechanics model for TNFR1 signaling”, JOURNAL OF BIOLOGICAL PHYSICS, 26, 219-234. (SCIE) (IF: 2.2; SCI ranking: 68.6%)

  • [32]     C. Guo, H. Levine and D.A. Kessler, 2000, “How does a beta-hairpin fold? Competition between topology and heterogeneity in a solvable model”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 97, 10775-10779. (SCIE) (IF: 9.1; SCI ranking: 16.2%)

  • [33]     C. Guo, H. Levine and D.A. Kessler, 2000, “Two state behavior in a solvable model of beta-hairpin folding. Physical Review Letters”, PHYSICAL REVIEW LETTERS, 84, 3490-3493. (SCIE) (IF: 9; SCI ranking: 10.6%)

  • [34]     C.H. Lee, C. Guo, and J. Wang, 1998, “Optical measurement of the viscoelastic and biochemical responses of living cells to mechanical perturbation”, OPTICS LETTERS, 23, 307-309. (SCIE) (IF: 3.3; SCI ranking: 34.3%)

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