郭青齡 / 副研究員

研究興趣

• cellular mechanisms of self-organization in biological systems, the biomechanics that enhance and stabilize spatiotemporal control

獎項及殊榮

經歷

• 2001. Assistant Professor, 2006-14; Caltech, 2014

學術著作

期刊論文

• [1]     Syue-Wei Peng, Mai-Huong T Ngo, Yung-Che Kuo, Ming-Hao Teng, Chin-Lin Guo, Hung-Cheng Lai, Te-Sheng Chang, Yen-Hua Huang, 2023, “Niclosamide Revitalizes Sorafenib through Insulin-Like Growth Factor 1 Receptor (IGF-1R)/Stemness and Metabolic Changes in Hepatocellular Carcinoma”, cancers, 15(3), 931, 931. (SCIE) (IF: 6.639; SCI ranking: 21%)
  
  
• [2]     Chen Lu-Chun, Nersisyan Stepan, Wu Chang-Jiun, Chang Che-Mai, Tonevitsky Alexander, Guo Chin-Lin, Chang Wei-Chiao, 2022, “On the peptide binding affinity changes in population-specific HLA repertoires to the SARS-CoV-2 variants Delta and Omicron”, Journal of Autoimmunity, 133, 102952. (SCIE) (IF: 7.094; SCI ranking: 20.4%)
  
  
• [3]     Chen Jia-Yang, Chou Hsu-Huan, Lim Syer Choon, Huang Yen-Jang, Lai Kuan-Chen, Guo Chin-Lin, Tung Chien-Yi, Su Chung-Tsai, Wang Jocelyn, Liu Edward, Han Hsiao-Fen, Yeh Po-Ying, Hu Chun-Mei, Dunn Alexander R., Frank Curtis W., Wu Yi-Chun, Yang Muh-Hwa, Chang Ying-Chih, 2022, “Multiomic characterization and drug testing establish circulating tumor cells as an ex vivo tool for personalized medicine”, iScience, 25(10), 105081. (SCIE) (IF: 5.458; SCI ranking: 19.2%)
  
  
• [4]     Guo Chin-Lin, 2022, “Self-Sustained Regulation or Self-Perpetuating Dysregulation: ROS-dependent HIF-YAP-Notch Signaling as a Double-Edged Sword on Stem Cell Physiology and Tumorigenesis”, Frontiers in Cell and Developmental Biology, 10, 862791. (SCIE) (IF: 6.684; SCI ranking: 26.7%,14.6%)
  
  
• [5]     Guo Chinlin, Chang Wei-Chiao, 2021, “Modeling-Based Estimate of the Vaccination Rate, Lockdown Rules and COVID-19”, Healthcare, 9(10), 1245. (SSCI) (IF: 2.645; SCI ranking: 52.8%)
  
  
• [6]     Au Heng-Kien, Peng Syue-Wei, Guo Chin-Lin, Lin Chien-Chia, Wang Yi-Lin, Kuo Yung-Che, Law Tsz-Yau, Ho Hong-Nerng, Ling Thai-Yen, Huang Yen-Hua, 2021, “Niche Laminin and IGF-1 Additively Coordinate the Maintenance of Oct-4 Through CD49f/IGF-1R-Hif-2α Feedforward Loop in Mouse Germline Stem Cells”, Frontiers in Cell and Developmental Biology, 9, 646644. (SCIE) (IF: 6.684; SCI ranking: 26.7%,14.6%)
  
  
• [7]     Ouyang Mingxing, Yu Jiun‐Yann, Chen Yenyu, Deng Linhong, Guo Chin‐Lin, 2021, “Cell‐extracellular matrix interactions in the fluidic phase direct the topology and polarity of self‐organized epithelial structures”, Cell Proliferation, 54(4), e13014. (SCIE) (IF: 6.831; SCI ranking: 23.6%)
  
  
• [8]     Wong Henry Sung-Ching, Guo Chin-Lin, Lin Gan-Hong, Lee Kang-Yun, Okada Yukinori, Chang Wei-Chiao, 2021, “Transcriptome network analyses in human coronavirus infections suggest a rational use of immunomodulatory drugs for COVID-19 therapy”, Genomics, 113(2), 564-575. (SCIE) (IF: 5.736; SCI ranking: 14.4%,15.9%)
  
  
• [9]     Chih-Yu Wu, Chin-Lin Guo, Yen-Ching Yang, Chao-Wei Huang, Jun-Yu Zeng, Zhen-Yu Guan, Yu-Chih Chiang, Peng-Yuan Wang, Hsien-Yeh Chen, 2020, “Parylene-Based Porous Scaffold with Functionalized Encapsulation of PRP and Living Stem Cells for Tissue Engineering Applications”, ACS Appl. Bio Mater., 3(10), 7193-7201.
  
  
• [10]     Wu MF, Lin CA, Yuan TH, Yeh HY, Su SF, Guo CL, Chang GC, Li KC, Ho CC, Chen HW, 2020, “The M1/M2 Spectrum and Plasticity of Malignant Pleural Effusion-Macrophage in Advanced Lung Cancer”, CANCER IMMUNOLOGY IMMUNOTHERAPY, 70(5), 1435--1450. (SCIE) (IF: 6.968; SCI ranking: 21.6%,18.9%)
  
  
• [11]     Tsai, Y. L. Yeh, P. Y. Huang, C. J. Guo*, C. L. Chang, Y. C., 2019, “Scalable Multilayer Cell Collector to Capture Circulating Tumor Cells with an Unlimited Volume Capacity”, ACS BIOMATERIALS SCIENCE & ENGINEERING, 5(6), 2725-2731. (SCIE) (IF: 4.749; SCI ranking: 41.5%)
  
  
• [12]     J-Y. Yu, S. Kim, D. B. Holland, M. A. Allodi, G. A. Blake, Y-G. Han and C. Guo, 2018, “Fiber-array illumination: realizing high temporal multiplexing in multifocal multiphoton microscopy with simplicity”, Scientific Reports, 8(1),14863. (SCIE) (IF: 4.38; SCI ranking: 23.3%)
  
  
• [13]     Yu, J. Y. Kim, J. Holland, D. B. Mou, Y. Chiu, H. Blake, G. A. Lee, W. Guo, C. L., 2018, “Multiphoton structured thin-plane imaging with a single optical path”, OPTICS LETTERS, 43(21),5271-5274. (SCIE, EI) (IF: 3.776; SCI ranking: 22.2%)
  
  
• [14]     G-Y. Zhuo, M-Y. Chen, C-Y. Yeh, J-Y. Yu, C Guo, and F-J. Kao., 2017, “Fast determination of three­dimensional fibril orientation of type­I collagen via macroscopic chirality”, APPLIED PHYSICS LETTERS, 110, 023702. (SCIE) (IF: 3.791; SCI ranking: 29.4%)
  
  
• [15]     T-Y. Chang, C. Chen, Y-C. Chang, C-H. Lu, M. Lee, S-T. Lu, D-Y. Wang, A. Wang, C. Guo and P-L. Cheng, 2017, “Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery”, ELIFE. (SCIE) (IF: 8.146; SCI ranking: 5.4%)
  
  
• [16]     Muller, N. Piel, M. Calvez, V. Voituriez, R. Goncalves-Sa, J. Guo, C. L. Jiang, X. Murray, A. Meunier, N, 2016, “A Predictive Model for Yeast Cell Polarization in Pheromone Gradients”, PLoS Computational Biology, 12(4), e1004795. (SCIE) (IF: 4.475; SCI ranking: 20.5%,13.8%)
  
  
• [17]     Meng-Tsung Hsu, Chin-Lin Guo, Angela Y. Liou, Ting-Ya Chang, Ming-Chong Ng, Yen-Lin Wu, Bogdab I. Florea, Herman S. Overkleeft, Yen-Ling Wu, Jung-Chi Liao, and Pei-Lin Cheng , 2015, “Stage-Dependent Axon transport of Proteasomes Contributes to Axon Development ”, Developmental Cell, in press. (SCIE) (IF: 12.27; SCI ranking: 9.7%,4.9%)
  
  
• [18]     Mou Y, Yu JY, Wannier TM, Guo CL, Mayo SL, 2015, “Computational design of co-assembling protein-DNA nanowires.”, Nature, 525(7568), 230-3. (SCIE) (IF: 49.962; SCI ranking: 1.4%)
  
  
• [19]     Guo CL, Cheng PL, 2015, “Second messenger signaling for neuronal polarization: cell mechanics-dependent pattern formation.”, Developmental neurobiology, 75(4), 388-401. (SCIE) (IF: 3.964; SCI ranking: 24.4%,44%)
  
  
• [20]     Abrams MJ, Basinger T, Yuan W, Guo CL, Goentoro L, 2015, “Self-repairing symmetry in jellyfish through mechanically driven reorganization.”, Proceedings of the National Academy of Sciences of the United States of America, 112(26), E3365-73. (SCIE) (IF: 11.205; SCI ranking: 11%)
  
  
• [21]     Guo CL, 2013, “Mechanical models for the self-organization of tubular patterns.”, Biomatter, 3(3).
  
  
• [22]     Guo CL, Harris NC, Wijeratne SS, Frey EW, Kiang CH, 2013, “Multiscale mechanobiology: mechanics at the molecular, cellular, and tissue levels.”, Cell & bioscience, 3(1), 25. (SCIE) (IF: 7.133; SCI ranking: 15.8%)
  
  
• [23]     J-Y. Yu, D. B. Holland, G. A. Blake, and C. Guo, 2013, “The wide Field optical sectioning of a microlens array and structural illumination-based plane-projection multi-photon microscopy”, OPTICS EXPRESS, 21, 2097-109. (SCIE) (IF: 3.894; SCI ranking: 20.2%)
  
  
• [24]     Guo CL, Ouyang M, Yu JY, Maslov J, Price A, Shen CY, 2012, “Long-range mechanical force enables self-assembly of epithelial tubular patterns.”, Proceedings of the National Academy of Sciences of the United States of America, 109(15), 5576-82. (SCIE) (IF: 11.205; SCI ranking: 11%)
  
  
• [25]     A. Grosberg, P-L. Kuo, C. Guo, N. A. Geisse, M-A. Bray, W. J. Adams, S. P. Sheehy, and K. K. Parker, 2011, “Self-organization of muscle cell structure and function”, PLoS Computational Biology, 7:e1001088. (SCIE) (IF: 4.475; SCI ranking: 20.5%,13.8%)
  
  
• [26]     J-Y. Yu, C-H. Kuo, D. B. Holland, Y-Y. Chen, M. Ouyang, G. A. Blake, R. Zadoyan, and C. Guo, 2011, “Wide-field optical sectioning for live-tissue imaging by plane-projection multi-photon microscopy”, JOURNAL OF BIOMEDICAL OPTICS, 16, 116009. (SCIE) (IF: 3.17; SCI ranking: 50%,30.3%,42.5%)
  
  
• [27]     Z. Chang, C. Guo, I. Ahronowitz, A. O. Stemmer-Rachamimov, M. MacCollin, F. P. Nunes, 2009, “A role for the p53 pathway in the pathology of meningiomas with NF2 loss. Journal of Neuro-oncology”, JOURNAL OF NEURO-ONCOLOGY, 9, 265-270. (SCIE) (IF: 4.13; SCI ranking: 31.7%,50.6%)
  
  
• [28]     P-W. Fok, C. Guo, and T. Chou, 2008, “Guanine-mediated adsorption of DNA repair proteins”, JOURNAL OF CHEMICAL PHYSICS, 129, 235101. (SCIE) (IF: 3.488; SCI ranking: 50%,24.3%)
  
  
• [29]     Mechanisms underlying sequence independent beta-sheet formation, 2002, “C. Guo, M. Cheung, D.A. Kessler, and H Levine”, JOURNAL OF CHEMICAL PHYSICS, 116, 4353-4365. (SCIE) (IF: 3.488; SCI ranking: 50%,24.3%)
  
  
• [30]     C. Guo and H. Levine, 2000, “A statistical mechanics model for TNFR1 signaling”, JOURNAL OF BIOLOGICAL PHYSICS, 26, 219-234. (SCIE) (IF: 1.365; SCI ranking: 87.5%)
  
  
• [31]     C. Guo, H. Levine and D.A. Kessler, 2000, “How does a beta-hairpin fold? Competition between topology and heterogeneity in a solvable model”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 97, 10775-10779. (SCIE) (IF: 11.205; SCI ranking: 11%)
  
  
• [32]     C. Guo, H. Levine and D.A. Kessler, 2000, “Two state behavior in a solvable model of beta-hairpin folding. Physical Review Letters”, PHYSICAL REVIEW LETTERS, 84, 3490-3493. (SCIE) (IF: 9.161; SCI ranking: 8.1%)
  
  
• [33]     C.H. Lee, C. Guo, and J. Wang, 1998, “Optical measurement of the viscoelastic and biochemical responses of living cells to mechanical perturbation”, OPTICS LETTERS, 23, 307-309. (SCIE) (IF: 3.776; SCI ranking: 22.2%)
  
  

學術會議(研討會)論文

• [1]     Y. G. Han, Y. G. J.-Y. Yu, and C. Guo, 2013, “Fiber array-based time-multiplexed multifocal multiphoton microscopy (TM-MMM): a new approach toward large numbers of time multiplexing”, paper presented at SPIE BiOS, Multiphoton Microscopy in the Biomedical Sciences XIV, Korea: SPIE, 2013-12-01 ~ 2013-12-10.
  
  
• [2]     Jiun-Yann Yu, Daniel B. Holland, Geoffrey A. Blake, and Chin-Lin Guo, 2013, “Temporal focusing generated via a height-staggered microlens array can be used for wide-field optical-sectioning microscopy”, paper presented at CLEO: Science and Innovations, San Jose, California United States: CLEO, 2013-06-09 ~ 2013-06-14.
  
  
• [3]     4. C. Guo, M. Ouyang, and J-Y. Yu, 2012, “Long-range mechanical force enables tubule self-organization”, Mechanics of Biological Systems and Materials, Volume 5, Chapter 3, Springer pages, paper presented at XII Society of Experimental Mechanics Congress Proceedings. Mechanics of Biological Systems and Materials, costa mesa CA: Society of Experimental Mechanics, 2012-10-01 ~ 2012-10-10.
  
  
• [4]     Guo C-L, Ouyang M, Yu J-Y, Price A, Maslov J, 2011, “Long-range mechanical force in colony branching and tumor invasion”, 8099: 809903–809901-809908 pages, paper presented at Proc of SPIE, San Diego: SPIE, 2011-07-01 ~ 2011-07-11.
  
  
• [5]     Jiun-Yann Yu ; Chun-Hung Kuo ; Zadoyan, R. ; Chin-Lin Guo, 2011, “Plane-projection multi-photon microscopy for high-frame-rate Live Tissue Imaging”, 1 - 2 pages, paper presented at Lasers and Electro-Optics (CLEO), Baltimore, MD: CLEO, 2011-05-01 ~ 2011-05-06.
  
  
• [6]     Chau-Hwang Lee ; Jyhpyng Wang ; Chin-Lin Guo, 1998, “Nanometer imaging by differential confocal microscopy and its applications in biology”, 1715 - 1718 vol.4 pages, paper presented at Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE, HK: IEEE, 1998-10-29 ~ 1998-11-01.
  
  

發現與突破

• [1]     西元年：2015
  研究人員(中)：郭青齡、Mou Y, Yu JY, Wannier TM, Mayo SL
  研究人員(英)：GUO, CHIN-LIN, Mou Y, Yu JY, Wannier TM, Mayo SL
  研究成果名稱(中)：自組裝蛋白質-脫氧核糖核酸納米線的計算設計
  研究成果名稱(英)：Computational design of co-assembling protein–DNA nanowires
  簡要記述(中)：因為生物納米技術的多功能性和生物相容性，研發生物分子自組裝納米材料一直是大家非常感興趣的課題。在過去十年中，這方面的設計一直 局限在單組成的納米結構。為了開發新的自組裝納米材料， 我們使用計算設計結構以及使用光學顯微鏡驗證新的蛋白質- 脫氧核糖核酸共同組裝納米材料。這材料使用蛋白質形成二聚體，以結合到DNA螺旋 ， 並依次建立DNA-蛋白質納米線 ，為新的納米材料設計啟發先河。
  簡要記述(英)：Biomolecular self-assemblies are of great interest to nanotechnologists because of their functional versatility and biocompatibility. Over the past decade, the design has been focused on single-component nanostructures. Here, for the development of new classes of protein–DNA hybrid materials, we use computational protein design and microscopy to create a protein–DNA co-assembling nanomaterial. The results lay a foundation for the new design of self-assembling bio-nanomaterials.
  

  主要相關著作：

  Mou Y, Yu JY, Wannier TM, Guo CL, Mayo SL, 2015, “Computational design of co-assembling protein-DNA nanowires.”, Nature, 525(7568), 230-3. (SCIE) (IF: 49.962; SCI ranking: 1.4%)

  
  
  
• [2]     西元年：2015
  研究人員(中)：郭青齡、Abrams MJ, Basinger T, Yuan W, Goentoro L
  研究人員(英)：GUO, CHIN-LIN, Abrams MJ, Basinger T, Yuan W, Goentoro L
  研究成果名稱(中)：水母通過機械重組自行修復體態對稱
  研究成果名稱(英)：Self-repairing symmetry in jellyfish through mechanically driven reorganization
  簡要記述(中)：當動物受傷會怎麼自我修復，一直是再生醫學一個熱門課題。藉由研究水母，我們發現一個以前未知的自我修復策略。當受傷時，水母通過重組現有零件，而非再生，來重建至關重要的體態勻稱。這項對再生醫學有影響的工作在 Washington post (http://www.washingtonpost.com/news/speaking-of-science/wp/2015/06/17/scientists-discover-the-self-repairing-mechanism-behind-a-jellyfishs-stunning-symmetry/ ) 和 New York Times (http://www.nytimes.com/2015/06/16/science/moon-jellyfish-tentacles-symmetry-realignment.html?_r=0) 都有報導。
  簡要記述(英)：What happens when an animal is injured and loses important structures? This is an important issue in regenerative medicine. Here, we report a previously unidentified strategy of self-repair, where moon jellyfish respond to injuries by reorganizing existing parts, and rebuilding essential body symmetry, without regenerating what is lost. This work is broadcasted on Washington post (http://www.washingtonpost.com/news/speaking-of-science/wp/2015/06/17/scientists-discover-the-self-repairing-mechanism-behind-a-jellyfishs-stunning-symmetry/ ) and New York Times (http://www.nytimes.com/2015/06/16/science/moon-jellyfish-tentacles-symmetry-realignment.html?_r=0). The results might provide a new strategy for the engineering of regenerative medicine.
  
  

  主要相關著作：

  Abrams MJ, Basinger T, Yuan W, Guo CL, Goentoro L, 2015, “Self-repairing symmetry in jellyfish through mechanically driven reorganization.”, Proceedings of the National Academy of Sciences of the United States of America, 112(26), E3365-73. (SCIE) (IF: 11.205; SCI ranking: 11%)