We are an interdisciplinary research group with members of diverse scientific backgrounds, including physics, biology, chemistry, and engineering. We are curious about how physical factors affect cell behaviors, and how cells utilize physical force to perform biological functions. The study of how cells sense and respond to the physical microenvironment is mechanobiology. In the past, most of studies are carried out on two-dimensional (2D) substrates. My lab focuses on three-dimensional behaviors, which are good for testing current understanding based on 2D systems. Our biological research addresses how the 3D microenvironment affects cellular shapes and functions, with the ultimate goals of  understanding cell morphodynamics and tissue morphogenesis and applying this knowledge to regenerative medicine and drug screening. In addition to investigating 3D mechanobiology, we also study mechanobiology in vivo, particularly, on zebrafish, which is a fascinating model system. Our approaches exploit knowledge and techniques from soft matter physics such as advanced optical microscopy, image analysis, and fluorescent probes for visualizing microscopic details.






Marco and Fu-lai's work is published on Nature Physics and featured as the cover in the September issue! Congratulations to Marco and Fu-lai! Here is the official news release.



You Hsuan Liu attended 2021 The 25th Biophysics Conference which held at National Cheng Kung University, Tainan, Taiwan.



Dr. Keng-hui Lin, Bor-Lin Huang and You Hsuan Liu attended Cell and Tissue Hydraulics Mini-Symposium (#hydraulics2021) which held online by Mechanobiology Institute, Singapore



We welcome you to join the Material, Mimics, and Microfluidics: Engineering Tools for Mechanobiology (#3M2021) which is co-oragnized by Dr. Keng-hui Lin and being held hybrid (both online and onsite).   



Congratulations Ching-chung Hsueh (薛景中) for winning Distinguished Poster Award in the 2018 Annual Meeting of the Physical Society of Taiwan held at National Taiwan University, Taipei, Taiwan.   



Congratulations Ting-Jie Wang for winning Distinguished Presentation Award in the  ASIoP Summer Student Program, 2017 held at Institute of Physics, Academia Sinica. 



Our lab visitor, Prof. Megan T. Valentine from Department of Mechanical Engineering, University of California, Santa Barbara, USA will give a Seminar Talk on "Learning from nature: how mussels stick to rocks using strong, tough and porous materials"



Congratulations Ivan Alex Priela Lazarte for winning Best Poster award at the BPS thematic meeting on Single-Cell Biophysics held at National Taiwan University, Taipei, Taiwan.


We welcome you to join the BPS thematic meeting on Single-Cell Biophysics which is co-oragnized by Dr. Keng-hui Lin and being held at National Taiwan University, Taipei, Taiwan.



Our lab visitor, Prof. Pakorn (Tony) Kanchanawong from Mechanobiology Institute & Department of Biomedical Engineering, National University of Singapore, Singapore will give a Seminar Talk on "Interference Techniques in Superresolution Microscopy" 



Prof. Christine Payne from School of Chemistry & Biochemistry, Georgia Institute of Technology, USA is going to visit our lab for a month. Welcome! 



Our lab visitor, Prof. Itai Cohen from Dept. of Physics, Cornell University, USA will give a Seminar Talk on "Graphene-based bimorphs for the fabrication of micron-sized, autonomous origami machines" 


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