We aim to map an entire human brain at sub-cellular resolution revealing the connections of this neuronal network. This feat is made possible by synchrotron x-ray microscopy though image acquisition at 3mm per minute and 0.3um resolution.
SYNAPSE is a coalition of synchrotron facilities including Pohang Light Source (Korea), Shanghai Synchrotron Radiation Facility, SPring-8 (Japan), Singapore Synchrotron Light Source, and Taiwan Photon Source, under the Asia Oceania Forum for Synchrotron Radiation Research (AOFSRR), with support from the local synchrotron, neurobiology and computing communities.
We plan to comprehensively map the neuron network of an entire human brain at sub-cellular level to reveal the connections. This historical target is made possible by the recent performances of synchrotron x-ray microscopy: 0.3 micrometer resolution at 1 mm3/min image taking speed. However, mapping one human brain would take a very long time and generate a huge amount of data. To overcome problems, SYNAPSE adopts a strategy of simultaneous image acquisition by several synchrotrons and coordinated data management. SYNAPSE will also use other advanced imaging techniques besides synchrotron microscopy: infrared spectromicroscopy, super-resolution visible light 3D microscopy and cryo-electron tomography.
The historical mission of mapping a human brain is also the first step to understand its functions, i.e., the incredible cognition and intelligence which is not generated by the mere combination of individual neurons but by the collective action of a massive, interactive network. This could lead to effective therapies for diseases, a planetary problem with huge social impact. SYNAPSE will also generate important technology byproducts in advanced imaging, new computational strategies and artificial intelligence.