2026/07/16(Thu) 11:00 -12:00 一樓演講廳 1F, Auditorium
Title
Active Multicellular Deformation as a Physical Readout of Biological State - From Hydra regeneration to patient-derived cancer organoids -
Speaker
Dr. Ryo Suzuki (Department of Biosciences & Informatics, Faculty of Science and Technology, Keio University)Abstract
Multicellular systems generate active forces through processes such as contractility, adhesion, cell rearrangement, and growth, but how these mechanical activities are coordinated with biological state to produce tissue-level function remains poorly understood. In this talk, I will discuss active multicellular deformation as a coarse-grained physical readout to study this problem. First, I will introduce our work on Hydra regeneration, where time-resolved deformation analysis reveals a biomechanical transition associated with body-axis formation and its coordination with Wnt/Hippo-Yap signalling. I will then extend this concept to patient-derived colorectal cancer organoids, in which early deformation dynamics and shape recovery after cell division reveal mutation-associated viscoelastic properties linked to cell-cell adhesion. Together, these studies suggest that active deformation dynamics provide a useful physical perspective for connecting biological state, mechanics, and multicellular function across different biological contexts.
Language
演講語言 (Language): in English