2021/08/11(Wed)     10:00 -12:00    視訊演講 Video Seminar [ Meeting Link / ID: 1708586692 / Password: PABS ]


Dynamic self-organization of living systems


Prof. Tetsuya Hiraiwa (Mechanobiology Institute, National University of Singapore, Singapore)


A cell which contains millions of various molecules is the building blocks of an organism. The process to form an organism requires the dynamic self-organization which is fascinating and mysterious. Particularly, I focus on building theoretical model to understand the migratory behaviors of cells and those which act in unison.

Migratory behavior is a ubiquitous kind of eukaryotic cell dynamics. Some cells migrate on a substrate according to intracellular signals that localize at their front or back, even without extracellular cues. In light of this, we theoretically investigated single cell migration with spontaneously broken isotropy, or intrinsic polarity [1,2], and applied the theory to the multicellular case where cells communicate with each other [3,4,5].

In the presentation, I will mainly deal with the multicellular case and address what forms of dynamic self-organization of migrating cells are caused through intercellular contact communication [4,5]. An individual cell-based model will be introduced based on single-cell migration study and the concept of collective motion of active matter [3]. Numerical results from a version of this model in which migrating cells perform two types of contact communications ubiquitous for cells will be explained [5]. Some of the results will be compared with experimental observations of a social amoeba [4]. I plan to also mention how this work can interplay with the investigations of dynamic self-organization in non-living active material systems [6,7]. This study may lead to unveiling yet-unknown mechanisms of dynamic self-organization.


演講語言 (Language): in English