2020/01/06(Mon) 10:30 -11:30 P101會議室 1F, P101 Meeting Room
Title
A hybrid approach for collective hydrodynamics of amphiphiles in a viscous solvent
Speaker
Prof. Yuan-Nan Young (New Jersey Institute of Technology)Abstract
Recent advancements in microfluidic experiments on vesicle hydrodynamics show that under extreme flowing conditions, a vesicle (a self-enclosing lipid bilayer membrane) may undergo large deformation and even lysis by strong shear and/or stretching. To investigate and model such topological change in the shape of a vesicle we propose a hybrid approach where the bilayer lipid molecules (amphiphiles) are coarse-grained while their hydrophobic interactions with each other and the solvent molecules are modeled in the continuum framework. Formulated as such, we demonstrate that such hybrid description of lipid hydrodynamics can capture (1) the self-assembly of amphiphiles in a water-like solvent, (2) fusion and fission of bilayers of amphiphiles, (3) the mechanical properties of a lipid bilayer membrane, (4) vesicle hydrodynamics in a shear flow (tanking treading and lysis), and (5) vesicle hydrodynamics in an extension flow (deformation, poration, and rupture).
Together with ongoing work that accounts for fluctuating hydrodynamics this hybrid approach shows great promise that it may be a good candidate to go beyond the Helfrich free energy for modeling the dynamics of lipid bilayer membranes in a viscous solvent. This talk is based on results summarized in an upcoming paper in SIAM Journal of Multiscale Modeling and Simulation (2020).
Language
演講語言 (Language): in English
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