專題演講

2019/09/17(Tue)     10:30 -11:30    五樓第一會議室5th Floor(1st meeting room)

Title

Colistin-resistant Klebsiella pneumoniae in Taiwan: Surveillance and resistant mechanisms

Speaker

Dr. Yi-Hsiang Cheng

National Yang Ming University

Abstract

Klebsiella pneumoniae infection is a serious threat to public health. However, carbapenem-resistant K. pneumoniae (CRKP) strains rapidly increased in recent years worldwide and their infections were associated with high mortality. Colistin is a last-resort antibiotic for treatment of CRKP, whereas report regarding surveillance and resistant mechanisms is lacking. In this study, colistin-resistant K. pneumoniae were collected from National Taiwan University Hospital and Taipei Veterans General Hospital, and molecular features of these strains were attempted to analyze. Our results showed capsular type K64 and sequence type ST11 were the prevalent capsular and ST types in colistin-resistant strains of Taiwan, and interruptions in mgrB that increased expression of the pmrHFIJKLM operon were major mechanisms contributing to colistin resistance. In addition, a novel two-component regulatory system and efflux pump, crrAB and H239_3064, involved in high colistin-resistance were identified. Overall, this study helps us understand how to manage these strains from the biological points and suggests a mechanism for CrrAB-mediated resistance to colistin in K. pneumoniae.