2025/12/30(Tue) 10:30 -12:00 一樓演講廳 1F, Auditorium
Title
A Principled Framework for Nonequilibrium Dynamics and its Applications to Biology
Speaker
Dr. Ying-Jen Yang (Laufer Center for Physical and Quantitative Biology, Stony Brook University)Abstract
The laws of material equilibria follow a well-known logic: a First Law (conservation); a Second Law (entropic tendency); and Legendre Transforms that give: (i) forces (T, P, μ) from observables (U, V, N), (ii) the conjugate phase-space coordinates they constitute, and (ii) the fluctuation-response and Maxwell Relations they obey. There has been no equivalent logic for non-equilibria such as energetic or material flows in biology. I will describe such a logic, which we call Caliber Force Theory (CFT). It requires replacing (U, V, N) with dynamic observables (node probabilities, edge traffics, and cycle fluxes) and state entropies with path entropies. I will describe some of the new concepts and relations it gives, and how it generalizes Stochastic Thermodynamics. Finally, I will demonstrate how CFT provides new insights into biological dynamics, ranging from the mechano-chemical coupling of molecular motors to the evolutionary strategies of populations in varying environments.
Language
演講語言 (Language): in English