2025/06/09(Mon) 11:00 -12:00 一樓演講廳 1F, Auditorium
Title
Reticulons on the Move: Extracellular Vesicles Link Neuronal and Glial ER Remodeling
Speaker
姚季光副研究員 (中央研究院生物化學研究所) Associate Research Fellow Chi-Kuang Yao (Institute of Biological Chemistry, Academia Sinica)Abstract
The research group led by Dr. Chi-Kuang Yao investigates the molecular mechanisms governing synaptic transmission, neuron-glia communication, and their relevance to neurological disorders. Building on this foundation, a major current focus of Dr. Yao's group is the discovery that ER-derived extracellular vesicles (EVs) mediate transcellular transfer of ER components, particularly the ER-shaping protein Reticulon, from neurons to glia. This transfer, regulated by neuronal activity and autophagy, maintains ER homeostasis across neurons and glia. Disruption of this pathway impairs glial ER morphology and neural circuit function, highlighting a novel intercellular mechanism essential for nervous system integrity.
Speaker Instroduction
Language
演講語言 (Language): in English