2023/12/12(Tue) 10:00 -11:00 一樓演講廳 1F, Auditorium
Title
Engineering Biomaterials for Stem Cell Morphogenesis and Drug Delivery
Speaker
Dr. Donny Hanjaya-Putra (Department of Aerospace and Mechanical Engineering, University of Notre Dame)Abstract
Stem cells respond to many cues from their microenvironment, which may include chemical and mechanical signals. These important cues can be incorporated into biomaterials to control stem cell differentiation and morphogenesis. Here, we discuss our recent efforts to design synthetic biomaterials as a modular platform to direct stem cell fate and morphogenesis into the blood and lymphatic vasculatures. First, we have used multilamellar lipid nanoparticles to rejuvenate vascular progenitor cells and improve their therapeutic potential. By controlling the release kinetic of various bioactive molecules to the surface of vascular progenitor cells, we not only improve cell migration, but also augment their angiogenic potential in vitro and in vivo. Second, we have used hyaluronic acid (HA)-based hydrogels to promote lymphatic network formation. By tuning the mechanical properties of the hydrogels, we have demonstrated that HA-hydrogels preserve key lymphatic phenotypes and matrix stiffness primes lymphatic tube formation directed by VEGF-C. Finally, we have utilized alternating current (AC) electrospray to encapsulate stem cells and produce granular hydrogels. The electrically induced “tip streaming” mode has enabled high-throughput encapsulation of stem cells with high efficiency and universality. Collectively, these recent advances in biomaterials design and fabrication provides us the opportunity to control stem cell differentiation and morphogenesis for a range of biomedical applications.
Language
演講語言 (Language): in English
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