Honor of Physicist

Dr. Keng-Hui Lins Group was awarded「2017 The 13th National Innovation Award」

Post Date:2017-01-11

Traditionally, cell biological investigations have mostly employed cells growing on flat, two-dimensional, hard substrates such as petri dish, which are of questionable utility in mimicking microenvironments in vivo. For example, endothelial cells on petri dish can not organize into a tube structure. The response to drug in vitro often lack of predictability in animal tests. The key to improve in vitro study is to grow cells in the third dimensions (3D). Many studies show that cellular behaviors in 3D culture are more physiologically relevant but the exact mechanism is unknown. However, it is hard to understand the mechanism when the scaffold is highly heterogeneous which makes systematic studies difficult. We engineered novel scaffolds whose pore size, porosity, stiffness, and protein conjugation are all tunable parameters. The novel scaffolds consist of uniform bubbles generated by a microfluidic device. The monodisperse foam scaffolds allow scientists to have more control over experimental parameters. We found that various cell types exhibit their physiological characters in the foam scaffolds. For example, epithelial cells form cyst-like structure. Myoblast cells form myotubes. Chondrocytes’ expression is close to health in vivo cells. Mesenchymal stromal cells possess better osteogenic differentiation power than their two-dimensional (2D) counterparts. We believe that the foam scaffolds are useful not only in the applications such as drug screening and tissue engineering but also in the fundamental studies of cellular biology. The technology has been exclusively licensed to Tantti for mass production. The product is available on Sigma-Aldrich.

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Journal Links: http://www.sigmaaldrich.com/catalog/substance/gomatrix9mm1234598765?lang=en®ion=TW

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