專題演講

2018/09/17(Mon)     10:30 -11:30    5th Floor(1st meeting room)

Title

Bridging individual cell behaviors to collective tissue morphogenesis

Speaker

Dr. Fu-lai Wen

RIKEN Center for Biosystems Dynamics Research, Japan

Abstract

Tissues consist of many cells. Each cell within the tissues can exhibit rich behaviors such as changes of cell shape, rearrangements of cell position, and increment/decrement of cell population. The various cell behaviors thus generate mechanical forces that are essential for the formation of tissue morphology during development. However, how individual cell behaviors are coordinated to sculpt the overall tissue morphology remains poorly understood. In this talk, I will introduce our work on modeling tissue morphogenesis at the fundamental level of individual cell behaviors in diverse model systems. Specifically, I will discuss how cell shape changes can lead to formation of tissue folds, and how rearrangement of cell positions can cause elongation of tissue tubes. A novel tissue morphogenesis that is driven by couplings between cell mechanics and cell polarity will also be discussed.