專題演講

2017/09/25(Mon)     14:00 -15:00    1st Floor

Title

Encoding information beyond the circadian timescale in the multi-oscillator circadian clock

Speaker

Asst. Prof. Jihwan Myung

Graduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, Taiwan

Abstract

The suprachiasmatic nucleus (SCN) is a collection of about 10,000 neurons, each of which
functions as a circadian clock with different periods and phases, that work in concert to form and
maintain the master circadian clock for the organism. The diversity among neurons confers on
the SCN the ability to robustly encode both the 24-hour light pattern as well as the seasonal time.
Synchronization brings the different neurons into line and reduces the large population to
essentially two oscillators, coordinated by a macroscopic network motif of asymmetric repulsiveattractive
coupling. We recount the steps leading to this simplification and rigorously examine
the two-oscillator case by seeking an analytical solution. Through these steps, we identify
physiologically relevant parameters that shape the behavior of the SCN network and define its
encoding capacity of temporal light patterns beyond the circadian timescale. (Paper)