專題演講 Seminar

Title

MODELING EPITHELIAL SHEET FOLDING

Speaker

温福來 博士 (日本理工研究所)

Dr. Fu-Lai Wen (RIKEN Quantitative Biology Center, Japan)

Abstract

Epithelial sheets consist of interconnected, polarized cells, serving as barriers to protect underlying tissues and regulate material exchange between inner and outer environments. During embryonic development, simple epithelia fold into complex structures, leading to the formation of neural tubes, guts, optic cups, branches of lungs, etc. Questions remain as to whether epithelia
can fold without external forces and what intrinsic mechanisms can induce it. By using a simple physical model, I will show that an autonomous folding can be induced by modulation of the intracellular mechanics along the basal-lateral as well as the apical cell surfaces. Those intrinsic mechanisms sculpt epithelia into distinct fold morphology. I will demonstrate that the different
mechanical modulations can be identified from the cell and tissue shapes obtained experimentally.

CV

Language

演講語言 (Language): in English

Hosted by

周家復
Chou, Chia-Fu Chou