周家復 / 研究員

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連絡資訊

學歷

  • 美國紐約州立大學水牛城分校 物理學博士
  • 國立清華大學物理系學士

秘書

周泳恩 / 886-2-2789-8364

研究興趣

生物物理、生醫光電、奈米生技、微奈米流體、液晶物理 ;

經歷

  • 2007- 合聘研究員, 基因體研究中心, 中央研究院
  • 2006- 合聘研究員, 應用科學研究中心, 中央研究院
  • 2005- 合聘副教授, 生醫工程系, 亞利桑那州立大學
  • 2003-2005- 副教授暨首要研究員暨共同創辦人,應用奈米生醫中心, 生物設計研究院,亞利桑那州立大學
  • 2000-2002 首要科學家, 微工藝研究室, 摩托羅拉實驗室
  • 1997-2000 NIH 博士後研究員, 物理系及分子生物系, 普林斯頓大學

學術著作

期刊論文

  • [1]     K. K. Sriram, S. Nayak, C.F. Chou*, A. Erbe* , 2016, “10-nm Deep, Sub-Nanoliter Fluidic Nanochannels on Germanium for Attenuated Total Reflection Infrared (ATR-IR) Spectroscopy”, ANALYST, DOI: 10.1039/C6AN01699E. (SCI) (IF: 4.107; SCI ranking: 9.5%)

  • [2]     R. Fernandez, B. Sanghavi, V. Farmehini, J. Chavez, J. Hagen, N. Kelley-Loughnane, C.F. Chou, N. Swami*, 2016, “Aptamer-functionalized graphene-gold nanocomposites for label-free detection of dielectrophoretic-enriched neuropeptide Y”, ELECTROCHEMISTRY COMMUNICATIONS, 72, 144–147. (SCI) (IF: 4.847; SCI ranking: 10.7%)

  • [3]     C. Sharma, A.K. Dinda, P.D. Potdar, C.F. Chou, N.C. Mishra *, 2016, “Fabrication and characterization of novel nanobiocomposite scaffold of chitosan–gelatin–alginate–hydroxyapatite for bone tissue engineering”, Materials Science & Engineering C-Materials for Biological Applications, 64, 416–427. (SCI) (IF: 3.088; SCI ranking: 51.5%)

  • [4]     P. Teerapanich, M. Pugnière, C. Henriquet , Y. L. Lin , C. F. Chou, T. Leichle* , 2016, “Nanofluidic Fluorescence Microscopy (NFM) for real-time monitoring of protein binding kinetics and affinity studies”, BIOSENSORS & BIOELECTRONICS, 88, 25–33. (SCI) (IF: 6.409; SCI ranking: 9.6%,6.7%,4.1%,3.6%,17.5%)

  • [5]     J.P. Shen and C.F. Chou* , 2016, “Morphological Plasticity of Bacteria − Open Questions”, Biomicrofluidics, 10(3), 031501. (SCI) (IF: 3.357; SCI ranking: 27.8%,27.4%,33.8%,9.7%)

  • [6]     Y.L. Lin, Y.J. Huang, P. Teerapanich, T. Leichlé, C.F. Chou* , 2016, “Multiplexed immunosensing and kinetics monitoring in nanofluidic devices with highly enhanced target capture efficiency”, Biomicrofluidics, 10(3), 034114. (SCI) (IF: 3.357; SCI ranking: 27.8%,27.4%,33.8%,9.7%)

  • [7]     A. Rohani, W. Varhue, K.T. Liao, C.F. Chou, N.S. Swami* , 2016, “Nanoslit design for ion conductivity gradient enhanced dielectrophoresis for ultrafast biomarker enrichment in physiological media”, Biomicrofluidics, 10, 033109. (SCI) (IF: 3.357; SCI ranking: 27.8%,27.4%,33.8%,9.7%)

  • [8]     B.J. Sanghavi, J.A. Moore, J.L. Chávez, J.A. Hagen, N. Kelley-Loughnane, C.F. Chou, N.S. Swami, 2016, “Aptamer-functionalized nanoparticles for surface immobilization-free electrochemical detection of cortisol in a microfluidic device”, BIOSENSORS & BIOELECTRONICS, 78, 244–252. (SCI) (IF: 6.409; SCI ranking: 9.6%,6.7%,4.1%,3.6%,17.5%)

  • [9]     P. Spuul, P.Y. Chi, C. Billottet, C.F. Chou*, E. Genot* , 2016, “Microfluidic devices for the study of actin cytoskeleton in constricted environments: Evidence for podosome formation in endothelial cells exposed to a confined slit”, METHODS, 94, 65–74. (SCI) (IF: 3.645; SCI ranking: 24.1%,30.3%)

  • [10]     Y.H Su, P.C. Chiang, L.J. Cheng, C.H. Lee, N.S. Swami*, C.F. Chou* , 2015, “High aspect ratio nanoimprinted grooves of poly(lactic-co-glycolic acid) control the length and direction of retraction fibers during fibroblast cell division”, Biointerphases, 10, 041008. (SCI) (IF: 3.374; SCI ranking: 26%,45.5%)

  • [11]     B.J. Sanghavi, W. Varhue, A. Rohani, K.T. Liao, L. Bazydlo, C.F. Chou*, N. S. Swami* , 2015, “Ultrafast immunoassays by coupling dielectrophoretic biomarker enrichment on nanoslit molecular dam with electrochemical detection on graphene”, Lab Chip, 15, 4563-4570. (SCI) (IF: 6.115; SCI ranking: 7.6%,13.4%,20%)

  • [12]     T. Leichlé and C.F. Chou* , 2015, “Biofunctionalized Nanoslit Sensors for Wash-Free and Fast Real-Time Sensing with Spatiotemporally Resolved Kinetics”, Biomicrofluidics, 9, 034103. (SCI) (IF: 3.357; SCI ranking: 27.8%,27.4%,33.8%,9.7%)

  • [13]     C. F. Chou*, P. K. Wei, and Y. L. Chen , 2014, “Preface to Special Topic: Selected Papers from the Advances in Microfluidics and Nanofluidics 2014 Conference in Honor of Professor Hsueh-Chia Chang's 60th Birthday”, Biomicrofluidics, 8, 051901. (SCI) (IF: 3.357; SCI ranking: 27.8%,27.4%,33.8%,9.7%)

  • [14]     K. K. Sriram, C.L. Chang, U. R. Kumar, C.F. Chou*, 2014, “DNA Combing on Low-Pressure Oxygen Plasma Modified Polysilsesquioxane Substrates For Single-Molecule Studies”, Biomicrofluidics, 8, 052102. (SCI) (IF: 3.357; SCI ranking: 27.8%,27.4%,33.8%,9.7%)

  • [15]     J. P. Shen, C. F. Chou* , 2014, “Bacteria under the Physical Constraints of Periodic Micro-Nanofluidic Junctions Reveal Morphological Plasticity and Dynamic Shifting of Min Patterns”, Biomicrofluidics, 8, 041103 (Fast Track Article). (SCI) (IF: 3.357; SCI ranking: 27.8%,27.4%,33.8%,9.7%)

  • [16]     K.K. Sriram, J.W. Yeh, Y.L. Lin, Y.R. Chang, C.F. Chou*, 2014, “Direct Optical Mapping of Transcription Factor Binding Sites on Field-stretched λ-DNA in Nanofluidic Devices”, NUCLEIC ACIDS RESEARCH, 42, e85. (SCI) (IF: 9.112; SCI ranking: 6.9%)

  • [17]     B. Sanghavi, W. Varhue, J. Chávez, C.F. Chou, N. S. Swami* , 2014, “Electrokinetic preconcentration and detection of neuropeptides at patterned graphene-modified electrodes in a nanochannel”, ANALYTICAL CHEMISTRY, 86 (9), 4120–4125. (SCI) (IF: 5.636; SCI ranking: 5.4%)

  • [18]     C. Lin, E. H.-L. Chen, L. Y.-L. Lee, R. L. Hsu, F. Y. Luh, L. L. Yang, C. F. Chou, L. D. Huang, C. C. Lin, R. P.-Y. Chen*, 2014, “Comparison of the anti-amyloidogenic effect of O-mannosylation, O-galactosylation, and O-GalNAc glycosylation”, CARBOHYDRATE RESEARCH, 387, 46–53. (SCI) (IF: 1.929; SCI ranking: 73.8%,33.3%,56.9%)

  • [19]     S. Gautam, C. F. Chou, A. K. Dinda, P. D. Potdar, N. C. Mishra* , 2014, “Fabrication and Characterization of PCL/Gelatin/Chitosan Ternary Nanofibrous Composite Scaffold for Tissue Engineering Applications”, JOURNAL OF MATERIALS SCIENCE, 49, 1076–1089. (SCI) (IF: 2.371; SCI ranking: 24.2%)

  • [20]     L. Lesser-Rojas, P. Ebbinghaus, G. Vasan, M. L. Chu, A. Erbe*, C. F. Chou*, 2014, “Low-Copy Number Protein Detection by Electrode Nanogap-Enabled Dielectrophoretic Trapping forSurface-enhanced Raman Spectroscopy and Electronic Measurements”, NANO LETTERS, 14(5), 2242–2250. (SCI) (IF: 13.592; SCI ranking: 5.1%,5%,5%,3.5%,4.2%,10.4%)

  • [21]     S. Gautam, C. F. Chou, A. K. Dinda, P. D. Potdar, N. C. Mishra*, 2014, “Surface Modification of Nanofibrous Polycaprolactone/Gelatin Composite Scaffold by Collagen I Grafting for Skin Tissue Engineering”, Materials Science & Engineering C-Materials for Biological Applications, 34, 402–409. (SCI) (IF: 3.088; SCI ranking: 51.5%)

  • [22]     L. Lesser-Rojas, K. K. Sriram, K.T. Liao, S.C. Lai, P.C. Kuo, M.L. Chu, C.F. Chou*, 2014, “Tandem array of nanoelectronic readers embedded coplanar to a fluidic nanochannel for correlated single biopolymer analysis”, Biomicrofluidics, 8, 016501. (SCI) (IF: 3.357; SCI ranking: 27.8%,27.4%,33.8%,9.7%)

  • [23]     A. Taloni*, J. W. Yeh, C. F. Chou* , 2013, “Scaling Theory of Stretched DNA In Nanoslits”, MACROMOLECULES, 46 (19), 7989–8002. (SCI) (IF: 5.8; SCI ranking: 3.7%)

  • [24]     V. Chaurey, A. Rohani, Y.H. Su, K.T. Liao, C.F. Chou*, N.S. Swami* , 2013, “Scaling down constriction-based (electrodeless) dielectrophoresis devices for trapping nanoscale bio-particles in physiological media of high-conductivity”, ELECTROPHORESIS, 34, 1097–1104.. (SCI) (IF: 3.028; SCI ranking: 30.4%,18.9%)

  • [25]     V. Chaurey, F. Block, Y.H. Su, P.C. Chiang, E. Botchwey, C.F. Chou, N.S. Swami*, 2012, “Nanofiber size-dependent sensitivity of fibroblast directionality to the methodology for scaffold alignment”, Acta Biomaterialia, 8, 3982–3990. (SCI) (IF: 6.025; SCI ranking: 3.9%,6.1%)

  • [26]     Kuo-Tang Liao, Chia-Fu Chou*, 2012, “Nanoscale molecular traps and dams for ultrafast protein enrichment in high-conductivity buffers (Featured in JACS Spotlights)”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134 (21), 8742−8745. (SCI) (IF: 12.113; SCI ranking: 6.4%)

  • [27]     Jia-Wei Yeh, Alessandro Taloni, Yeng-Long Chen, Chia-Fu Chou*, 2012, “Entropy-driven single molecule tug-of-war of DNA at micro-nanofluidic interfaces (Research Highlighted by Nature)”, NANO LETTERS, 12 (3), 1597–1602. (SCI) (IF: 13.592; SCI ranking: 5.1%,5%,5%,3.5%,4.2%,10.4%)

  • [28]     T. Leïchlé, Y.L. Lin, P.C. Chiang, K.T. Liao, S.M. Hu, C.F. Chou* , 2012, “Biosensor-compatible encapsulation for pre-functionalized nanofluidic channels using asymmetric plasma treatment”, SENSORS AND ACTUATORS B-CHEMICAL, 161, 805–810. (SCI) (IF: 4.097; SCI ranking: 10.8%,21.4%,5.4%)

  • [29]     P.K. Lin, C.C. Hsieh, Y.L Chen*, C.F. Chou* , 2012, “Effects of Topology and Ionic Strength on Double-Stranded DNA Confined in Nanoslits”, MACROMOLECULES, 45(6), 2920–2927. (SCI) (IF: 5.8; SCI ranking: 3.7%)

  • [30]     V. Chaurey, C. Polanco, C.F. Chou*, N.S. Swami*, 2012, “Floating-electrode enhanced constriction dielectrophoresis for biomolecular trapping in media of high-conductivity”, Biomicrofluidics, 6, 012806. (SCI) (IF: 3.357; SCI ranking: 27.8%,27.4%,33.8%,9.7%)

  • [31]     V. Chaurey, K.T. Liao, C. Polanco, C.F. Chou*, N.S. Swami*, 2012, “Nano-constriction device for rapid protein pre-concentration through balance of electrokinetic forces”, ELECTROPHORESIS, 33, 1958-1966. (SCI) (IF: 3.028; SCI ranking: 30.4%,18.9%)

  • [32]     C.C. Wang, Y.C. Kao, P.Y. Chi, C.W. Huang, J.Y. Lin, C.F. Chou, J.Y. Cheng*, C.H. Lee, 2011, “Asymmetric cancer-cell filopodium growth induced by electric-fields in a microfluidic culture chip”, LAB ON A CHIP, 11, 695-699. (SCI) (IF: 6.115; SCI ranking: 7.6%,13.4%,20%)

  • [33]     Y.L. Chen, P. K. Lin, C.F. Chou , 2010, “Generalized force-extension relation for worm-like chains in slit confinement”, MACROMOLECULES, 43, 10204–10207. (SCI) (IF: 5.8; SCI ranking: 3.7%)

  • [34]     V. Chaurey, P.C. Chiang, C. Polanco, Y.H. Su, C.F Chou*, N. Swami*, 2010, “Interplay of Electrical Forces for Alignment of Sub-100 nm Electrospun Nanofibers on Insulator Gap Collectors”, LANGMUIR, 26, 19022–19026. (SCI) (IF: 4.457; SCI ranking: 19.1%,23.7%,13.5%)

  • [35]     N. Swami, C. F. Chou*, V. Ramamurthy, V. Chaurey , 2009, “Enhancing DNA hybridization kinetics through constriction-based dielectrophoresis”, LAB ON A CHIP, 9, 3212. (SCI) (IF: 6.115; SCI ranking: 7.6%,13.4%,20%)

  • [36]     J. Gu, R. Gupta, C.F. Chou, Q. Wei, F. Zenhausern, 2007, “A simple polysilsesquioxane sealing of nanofluidic channels below 10 nm at room temperature”, LAB ON A CHIP, 7, 1198. (SCI) (IF: 6.115; SCI ranking: 7.6%,13.4%,20%)

  • [37]     N. Swami, C.F. Chou, R. Terbrueggen , 2005, “Two-potential electrochemical surface probe of DNA immobilization”, LANGMUIR, 21, 1937. (SCI) (IF: 4.457; SCI ranking: 19.1%,23.7%,13.5%)

  • [38]     L.J. Guo, X. Cheng, C.F. Chou* , 2004, “Fabrication of Size-Controllable Nanofluidic Channels by Nanoimprinting and Its Application for DNA Stretching”, NANO LETTERS, 4, 69-73. (SCI) (IF: 13.592; SCI ranking: 5.1%,5%,5%,3.5%,4.2%,10.4%)

  • [39]     C.F. Chou*, F. Zenhausern , 2003, “Electrodeless Dielectrophoresis for Micro Total Analysis Systems”, IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE, 22, 62-67.

  • [40]     C.Y. Chao, T.C. Pan, C.F. Chou, J.T. Ho , 2003, “Multiple Electron Diffraction and Two-Dimensional Crystalline Order in Liquid-Crystal Thin Films”, PHYSICAL REVIEW LETTERS, 91, 125504. (SCI) (IF: 7.512; SCI ranking: 7.7%)

  • [41]     D. Sadler, R. Changrani, P. Roberts, C.F. Chou, F. Zenhausern , 2003, “Thermal Management of BioMEMS: Temperature Control for Ceramic-based PCR and DNA Detection Devices”, IEEE TRANSACTIONS ON COMPONENTS AND PACKAGING TECHNOLOGIES, 26 (2), 309-316.

  • [42]     C.F. Chou*, R. Changrani, P. Roberts, D. Sadler, S. Lin, A. Mulholland, N. Swami, R. Terbrueggen, F. Zenhausern, 2002, “A Miniaturized Cyclic PCR Device-Modeling and Experiments”, MICROELECTRONIC ENGINEERING, 61/62, 921-925. (SCI) (IF: 1.197; SCI ranking: 51.8%,77.5%,62.1%,65.3%)

  • [43]     C.F. Chou, J.O. Tegenfeldt, O. Bakajin, S.S. Chan, E.C. Cox, N. Darnton, T.A.J. Duke, R.H. Austin , 2002, “Electrodeless Dielectrophoresis of Single and Double Stranded DNA”, BIOPHYSICAL JOURNAL, 83, 2170. (SCI) (IF: 3.972; SCI ranking: 23.3%)

  • [44]     J. O. Tegenfeldt, O. Bakajin, C. F. Chou, S. S. Chan, R. H. Austin, W. Fann, L. Liou, E. Chan, T. Duke, and E. C. Cox, 2001, “Near-Field Scanner for Moving Molecules”, PHYSICAL REVIEW LETTERS, 86, 1378-1381. (SCI) (IF: 7.512; SCI ranking: 7.7%)

  • [45]     O. Bakajin, T. A. J. Duke, J. Tegenfeldt, C. F. Chou, S. S. Chan, R. H. Austin and E. C. Cox , 2001, “Separation of 100 kilobase DNA molecules in 10 seconds”, ANALYTICAL CHEMISTRY, 73, 6053-6056. (SCI) (IF: 5.636; SCI ranking: 5.4%)

  • [46]     C.F. Chou, R.H. Austin, O. Bakajin, J.O. Tegenfeldt, J.A. Castelino, S.S. Chan, E.C. Cox, H.G. Craighead, N. Darton, T.A.J. Duke, J. Han, S.W. Turner , 2000, “Sorting Biomolecules with Microdevices”, Electrophoresis, 21, 81-90. (SCI) (IF: 3.028; SCI ranking: 30.4%,18.9%)

  • [47]     C.Y. Chao, T.C. Pan, C.F. Chou, and J.T. Ho , 2000, “Structural Characterization of Surface Hexatic Behavior in Free-Standing 4O.8 Liquid-Crystal Films”, PHYSICAL REVIEW E, 62 (2): R1485-R1488. (SCI) (IF: 2.288; SCI ranking: 29%,9.3%)

  • [48]     C.F. Chou, O. Bakajin, S.W. Turner, T. Duke, S.S. Chan, R.H. Austin, E.C. Cox, and H.G. Craighead , 1999, “Sorting by Diffusion: an Asymmetric Obstacle Course for Continuous Molecular Separation”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96, 13762-13765. (SCI) (IF: 9.674; SCI ranking: 7%)

  • [49]     O.B. Bakajin, T.A.J. Duke, C.F. Chou, S.S. Chan, R.H. Austin, and E.C. Cox , 1998, “Electrohydrodynamic Stretching of DNA in Confined Environments”, PHYSICAL REVIEW LETTERS, 80, 2737-2740. (SCI) (IF: 7.512; SCI ranking: 7.7%)

  • [50]     C.F. Chou*, A.J. Jin, S.W. Hui, C.C. Huang, and J.T. Ho , 1998, “Multiple-Step Melting in Two-Dimensional Hexatic Liquid-Crystal Films”, SCIENCE, 280, 1424-1426. (SCI) (IF: 33.611; SCI ranking: 3.5%)

  • [51]     M. Veum, C.C. Huang, C.F. Chou, and V. Surendranath , 1997, “Stability and Phase Transitions of Single-Molecular-Layer Free-Standing Liquid-Crystal Films”, PHYSICAL REVIEW E, 56, 2298-2301. (SCI) (IF: 2.288; SCI ranking: 29%,9.3%)

  • [52]     C.Y. Chao, S.W. Hui, J.E. Maclennan, C.F. Chou, and J.T. Ho , 1997, “Surface-Freezing Transitions and Novel Tilted Hexatic Phases in Smectic Liquid-Crystal Films”, PHYSICAL REVIEW LETTERS, 78, 2581-2584. (SCI) (IF: 7.512; SCI ranking: 7.7%)

  • [53]     C.Y. Chao, C.F. Chou, J.T. Ho, S.W. Hui, A.J. Jin, and C.C. Huang , 1996, “Nature of Layer-by-Layer Freezing in Free-Standing 4O.8 Films”, PHYSICAL REVIEW LETTERS, 77, 2750-2753. (SCI) (IF: 7.512; SCI ranking: 7.7%)

  • [54]     A.J. Jin, M. Veum, T. Stoebe, C.F. Chou, J.T. Ho, S.W. Hui, V. Surendranath, and C.C. Huang , 1996, “Nature of the Smectic-A–Hexatic-B–Crystal-B Transitions of One Liquid-Crystal Compound”, PHYSICAL REVIEW E, 53, 3639-3646. (SCI) (IF: 2.288; SCI ranking: 29%,9.3%)

  • [55]     C.F. Chou, J.T. Ho, S.W. Hui, and V. Surendranath , 1996, “Scaling of 6n-Fold Bond-Orientational Order Parameters in a Hexatic Liquid-Crystal Thin Film”, PHYSICAL REVIEW LETTERS, 76, 4556-4559. (SCI) (IF: 7.512; SCI ranking: 7.7%)

  • [56]     A.J. Jin, M. Veum, T. Stoebe, C.F. Chou, J.T. Ho, S.W. Hui, V. Surendranath, and C.C. Huang , 1995, “Calorimetric and Structural Characterization of Thin Liquid-Crystal Films Exhibiting the Smectic-A–Hexatic-B–Crystal-B Transitions”, PHYSICAL REVIEW LETTERS, 74, 4863-4866. (SCI) (IF: 7.512; SCI ranking: 7.7%)

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