胡進錕 / 研究員

pi_image

連絡資訊

學歷

  • 國立清華大學物理系博士

秘書

饒宇軒 / 886-2-2789-8916

研究興趣

統計物理 ; 計算物理 ; 非線性科學 ; 理論生物物理 ;

經歷

  • 多倫多大學副研究員
  • 哈佛大學訪問學者
  • IUPAP統計物理委員會秘書

學術著作

期刊論文

  • [1]     Yu-Hsin Hsieh, Chi-Ning Chen*, and Chin-Kun Hu*, 2016, “Efficient algorithm for computing exact partition functions of lattice polymer models”, COMPUTER PHYSICS COMMUNICATIONS, 209, 27-33. (SCI) (IF: 3.635; SCI ranking: 10.6%,1.9%)

  • [2]     Nickolay Sh. Izmailian*, Ming-Chya Wu*, and Chin-Kun Hu*, 2016, “Finite-size corrections and scaling for the dimer model on the checkerboard lattice”, PHYSICAL REVIEW E, 94, 052141. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [3]     David B Saakian* and Chin-Kun Hu*, 2016, “Solution of classical evolutionary models in the limit when the diffusion approximation breaks down”, PHYSICAL REVIEW E, 94, 042422. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [4]     David B. Saakian* , Tatiana Yakushkina* and Chin-Kun Hu*, 2016, “The rich phase structure of a mutator model”, Scientific Reports, 6, 34840. (SCI) (IF: 5.228; SCI ranking: 11.1%)

  • [5]     Nguyen Quoc Thai, Ning-Hsuan Tseng, Mui Thi Vu, Tin Trung Nguyen, Huynh Quang Linh, Chin-Kun Hu*, Yun-Ru Chen*, and Mai Suan Li:*, 2016, “Discovery of DNA dyes Hoechst 34580 and 33342 as Good Candidates for Inhibiting Amyloid Beta Formation: In silico and in vitro Study”, JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 30, 639-650. (SCI) (IF: 3.199; SCI ranking: 12.5%,39.1%,29.2%)

  • [6]     Chun-Ling Chang, Alexander S. Fridman, Inessa E. Grigoryan, Elena N. Galyuk, Oleg N. Murashko, Chin-Kun Hu* and Dmitri Y. Lando*, 2016, “Estimation of the Diversity between DNA Calorimetrical Profiles, Differential Melting Curves and Corresponding Melting Temperatures, Biopolymers”, Biopolymers, 105, 832-839. (SCI) (IF: 2.248; SCI ranking: 64.4%,54.2%)

  • [7]     K. G. Petrosyan* and Chin-Kun Hu*, 2016, “Noise-induced multistability in the regulation of cancer by genes and pseudogenes”, JOURNAL OF CHEMICAL PHYSICS, 145, 045102. (SCI) (IF: 2.894; SCI ranking: 37.5%,25.7%)

  • [8]     Guan-Rong Huang, David B. Saakian* and Chin-Kun Hu*, 2016, “Accurate analytic results for the steady state distribution of the Eigen Model,”, JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, 85, 044803. (SCI) (IF: 1.559; SCI ranking: 39.2%)

  • [9]     Liming Pan, Tao Zhou*, Linyuan Lu* and Chin-Kun Hu*, 2016, “Predicting missing links and identifying spurious links via likelihood analysis”, Scientific Reports, 6, 22955. (SCI) (IF: 5.228; SCI ranking: 11.1%)

  • [10]     Alexander S. Bratus, Chin-Kun Hu, and Mikhail V. Safro*, 2016, “On Diffusive Stability of Eigen’s Quasispecies Model”, JOURNAL OF DYNAMICAL AND CONTROL SYSTEMS, 22, 1-14. (SCI) (IF: 0.422; SCI ranking: 89.8%,89.8%)

  • [11]     Ting-Ting-Chi*, Shih-Chieh Wang, and Chin-Kun Hu*, 2015, “Word population analysis and other evidences indicate that Shiji was amended by Liu Xiang”, PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 437, 408-417. (SCI) (IF: 1.785; SCI ranking: 29.1%)

  • [12]     Tatiana Yakushkina*, David B. Saakian*, and Chin-Kun Hu*, 2015, “Exact Dynamics for a Mutator Gene Model”, CHINESE JOURNAL OF PHYSICS, 53, 100904. (SCI) (IF: 0.464; SCI ranking: 89.9%)

  • [13]     Y.Sh. Mamasakhlisov, S. Bellucci, Shura Hayryan, H. Caturyan, Z. Grigoryan, and Chin-Kun Hu*, 2015, “Collapse and hybridization of RNA: View from replica technique”, EUROPEAN PHYSICAL JOURNAL E, 38: 100. (SCI) (IF: 1.625; SCI ranking: 51.8%,69.4%,49.7%,50.9%)

  • [14]     S. G. Gevorkian, A. E. Allahverdyan, D. S. Gevorgyan, and Chin-Kun Hu*, 2015, “Thermal-induced force release in oxyhemoglobin”, Scientific Reports, 5, 13064. (SCI) (IF: 5.228; SCI ranking: 11.1%)

  • [15]     Guan-Rong Huang, W. Y. Tsai, J. C. Huang*, and Chin-Kun Hu, 2015, “Analytical modelling for ultrasonic surface mechanical attrition treatment”, AIP Advances, 5, 077126. (SCI) (IF: 1.444; SCI ranking: 57.2%,71.1%,56.6%)

  • [16]     K G Petrosyan* and Chin-Kun Hu*, 2015, “Fluctuation effects in gene regulation by microRNAs and correlations between gene and pseudogene mRNAs in the control of cancer”, JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT, P07019. (SCI) (IF: 2.091; SCI ranking: 21.5%,15.1%)

  • [17]     Dmitri Y. Lando*, Alexander S. Fridman, Chun-Ling Chang, Inessa E. Grigoryan, Elena N. Galyuk, Oleg N. Murashko, Chun-Chung Chen, Chin-Kun Hu*, 2015, “Determination of the DNA melting temperature and temperature melting range for multi-peak differential melting curves”, Analytical Biochemistry, 407, 28-36. (SCI) (IF: 2.243; SCI ranking: 64.7%,42.7%,54.5%)

  • [18]     Tatiana Yakushkina, David B. Saakian, Alexander Bratus, Chin-Kun Hu*, 2015, “Evolutionary games with randomly changing payoff matrices”, Journal of the Physical Society of Japan, 84, 064802. (SCI) (IF: 1.559; SCI ranking: 39.2%)

  • [19]     N. Sh. Izmailian*, Chin-Kun Hu*, and R. Kenna*, 2015, “Exact solution of the dimer model on the generalized finite checkerboard lattice”, Physical Review E, 91, 062139. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [20]     Chin-Kun Hu*, 2015, “Proteins aggregation and human diseases”, Journal of Physics: Conference Series, 604, 012009. (SCI-web)

  • [21]     Jan Busa Jr., Jan Busa, Shura Hayryan, Chin-Kun Hu*, and Ming-Chya Wu, 2015, “An OpenCL version of the package for detection and quantitative analysis of internal cavities in a system of overlapping balls: application to proteins”, COMPUTER PHYSICS COMMUNICATIONS, 190, 224-227. (SCI) (IF: 3.635; SCI ranking: 10.6%,1.9%)

  • [22]     P. Kopčanský, L. Tomčo, J. Jadzyn, J. Swiergiel, J. Majorošová, M. Kubovčíková, M. Timko, M. Rajňák, K. Šipošová, Z. Gažová, Z. Bednariková, N. Tomašovicová, Chin-Kun Hu, S. Hayryan, I. Studenyak, T.M. Kovalchuk, O.V. Kovalchuk, 2015, “Dielectric properties of lyotropic magnetic liquid crystal”, Acta Physica Polonica A, 127, 632-634. (SCI) (IF: 0.525; SCI ranking: 83.5%)

  • [23]     H. Chang, X.-L. Xu*, C.-K. Hu*, C. Fu, A.-X. Feng and D.-R. He, 2014, “A manipulator game model of urban public traffic network”, PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 416, 378-385. (SCI) (IF: 1.785; SCI ranking: 29.1%)

  • [24]     Dan Berco*, Chin-Kun Hu*, 2014, “A Spherical Harmonic Transform Spectral Analysis of a Localized Surface Plasmon on a Gold Nano Shell”, Journal of Computational Chemistry, 35, 2225-2230. (SCI) (IF: 3.648; SCI ranking: 25.2%)

  • [25]     Guan-Rong Huang, David B. Saakian*, Olga Rozanova, Jui-Ling Yu, and Chin-Kun Hu*, 2014, “Exact solution of master equation with Gaussian and compound Poisson noises”, JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT, P11033. (SCI) (IF: 2.091; SCI ranking: 21.5%,15.1%)

  • [26]     Berco Dan*, Chin-Kun Hu, 2014, “Plasmon resonance based analysis of a single protein conjugated Au nanoshell”, Biointerphases, 9, 031017. (SCI) (IF: 2.105; SCI ranking: 57.6%,58.3%)

  • [27]     Dmitri Y. Lando*, Chun-Ling Chang, Alexander S. Fridman, Inessa E. Grigoryan, Elena N. Galyuk, Ya-Wei Hsueh, Chin-Kun Hu*, 2014, “Comparative thermal and thermodynamic study of DNA chemically modified with antitumor drug cisplatin and its inactive analog transplatin”, Journal of Inorganic Biochemistry, 137, 85-93. (SCI) (IF: 3.205; SCI ranking: 23.9%,38.8%)

  • [28]     David B. Saakian*, Makar H. Ghazaryan*, Chin-Kun Hu*, 2014, “Punctuated equilibrium and shock waves in molecular models of biological evolution”, PHYSICAL REVIEW E, 90, 022712. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [29]     Phan Minh Truong, Man Hoang Viet, Phuong H. Nguyen, Chin-Kun Hu, Mai Suan Li*, 2014, “Effect of Taiwan Mutation (D7H) on Structures of Amyloid‑ Peptides: Replica Exchange Molecular Dynamics Study”, The Journal of Physical Chemistry B, 118, 8972−8981. (SCI) (IF: 3.187; SCI ranking: 33.3%)

  • [30]     Hsin-Lin Chiang, Chun-Jung Chen, Hisashi Okumura, and Chin-Kun Hu*, 2014, “Transformation Between alpha-Helix and beta-Sheet Structures of One and Two Polyglutamine Peptides in Explicit Water Molecules by Replica-Exchange Molecular Dynamics Simulations”, JOURNAL OF COMPUTATIONAL CHEMISTRY, 35, 1430–1437. (SCI) (IF: 3.648; SCI ranking: 25.2%)

  • [31]     Yevgeni Mamasakhlisov, Shura Hayryan, Vladimir Morozov, and Chin-Kun Hu*, 2014, “Kinetics of the long ssRNA: Steady state”, EPL, 106, 48007. (SCI) (IF: 1.963; SCI ranking: 24.1%)

  • [32]     K. G. Petrosyana* and Chin-Kun Hu*, 2014, “Oscillations in probability distributions for stochastic gene expression”, JOURNAL OF CHEMICAL PHYSICS, 140, 205104. (SCI) (IF: 2.894; SCI ranking: 37.5%,25.7%)

  • [33]     K. G. Petrosyan, Chin-Kun Hu*, 2014, “Nonequilibrium Lyapunov function and a fluctuation relation for stochastic systems: Poisson-representation approach”, PHYSICAL REVIEW E, 89, 042132. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [34]     Chin-Kun Hu*, 2014, “Historical Review on Analytic, Monte Carlo, and Renormalization Group Approaches to Critical Phenomena of Some Lattice Models”, CHINESE JOURNAL OF PHYSICS, 52, 1-76. (SCI) (IF: 0.464; SCI ranking: 89.9%)

  • [35]     Man Hoang Viet, Chun-Yu Chen, Chin-Kun Hu, Yun-Ru Chen*, Mai Suan Li*, 2013, “Discovery of Dihydrochalcone as Potential Lead for Alzheimer’s Disease: In Silico and In Vitro Study”, PLoS One, 8(11): e79151. (SCI) (IF: 3.057; SCI ranking: 17.5%)

  • [36]     David B. Saakian* and Chin-Kun Hu*, 2013, “Evolutionary advantage via common action of recombination and neutrality”, PHYSICAL REVIEW E, 88, 052717. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [37]     Sasun G. Gevorkian, Armen E. Allahverdyan, David S. Gevorgyan. Aleksandr L. Simonian, Chin-Kun Hu*, 2013, “Stabilization and Anomalous Hydration of Collagen Fibril”, PLoS One, 8(11), e78526. (SCI) (IF: 3.057; SCI ranking: 17.5%)

  • [38]     Chi-Ning Chen*, Yu-Hsin Hsieh, and Chin-Kun Hu*, 2013, “Heat capacity decomposition by partition function zeros”, EPL, 104, 20005. (SCI) (IF: 1.963; SCI ranking: 24.1%)

  • [39]     Maksim Kouza*, Chin-Kun Hu* Mai Suan Li*, and Andrzej Kolinski*, 2013, “A structure-based model fails to probe the mechanical unfolding pathways”, JOURNAL OF CHEMICAL PHYSICS, 139, 065103. (SCI) (IF: 2.894; SCI ranking: 37.5%,25.7%)

  • [40]     W.-J. Ma*, S.-C. Wang, C.-N. Chen, and C.-K. Hu*, 2013, “Crossover behavior of stock returns and mean square displacements of particles governed by the Langevin equation”, EPL, 102, 66003. (SCI) (IF: 1.963; SCI ranking: 24.1%)

  • [41]     Hsin-Lin Chiang, Son Tung Ngo, Chin-Kun Hu*, and Mai Suan Li*, 2013, “Oligomerization of peptides LVEALYL and RGFFYT and their binding affinity to insulin”, Plos one, 8, e65358. (SCI) (IF: 3.057; SCI ranking: 17.5%)

  • [42]     N. T. Co, C.-K. Hu* , and M. S. Li*, 2013, “Dual effect of crowders on fibrillation kinetics of polypeptide chains revealed by lattice models”, JOURNAL OF CHEMICAL PHYSICS, 138, 185101. (SCI) (IF: 2.894; SCI ranking: 37.5%,25.7%)

  • [43]     N. Sh. Izmailian and Chin-Kun Hu*, 2013, “Amplitude ratios for critical systems in the c= −2 universality class”, PHYSICAL REVIEW E, 87, 012110. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [44]     D. Y. Lando*, E. N. Galyuk, C.-L. Chang, C.-K. Hu*, 2012, “Temporal behavior of DNA thermal stability in the presence of platinum compounds. Role of monofunctional and bifunctional adducts”, JOURNAL OF INORGANIC BIOCHEMISTRY, 117, 164. (SCI) (IF: 3.205; SCI ranking: 23.9%,38.8%)

  • [45]     Jr. Jan. Busa; Shura, Hayryan, Ming-Chya Wu, Jan Bush, Chin-Kun Hu*, 2012, “ARVO-CL:The OpenCL Version of the ARVO Package -- An Efficient Tool for Computing the Accessible Surface Area and the Excluded Volume of Proteins via Analytical Equations”, COMPUTER PHYSICS COMMUNICATIONS, 183, 2494. (SCI) (IF: 3.635; SCI ranking: 10.6%,1.9%)

  • [46]      Z. Kirakosyan, D. B. Saakian and C.-K. Hu*, 2012, “Eigen model with correlated multiple mutations and solution of error catastrophe paradox in the origin of life”, JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, 81, 114801. (SCI) (IF: 1.559; SCI ranking: 39.2%)

  • [47]     Yevgeni Sh. Mamasakhlisov, Shura Hayryan, and Chin-Kun Hu*, 2012, “Long charged macromolecule in an entropic trap with rough surfaces”, PHYSICAL REVIEW E, 86, 051904. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [48]     David. B. Saakian*, Zara Kirakosyan and Chin-Kun Hu*, 2012, “Biological evolution in a multidimensional fitness landscape”, Physical Review E, 86, 031920. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [49]     Olga S. Rozanova*, Jui-Ling Yu, Chin-Kun Hu, 2012, “On position of vortex in a two-dimensional model of atmosphere”, Nonlinear Analysis Series B-Real World Applications, 13, 1941-1954.

  • [50]     Chun-Ling Chang, Dmitri Y. Lando*, Alexander S. Fridman, Chin-Kun Hu*, 2012, “Thermal stability of DNA with interstrand crosslinks”, Biopolymers, 97, 807. (SCI) (IF: 2.248; SCI ranking: 64.4%,54.2%)

  • [51]     Karen G. Petrosyan* and Chin-Kun Hu*, 2012, “Stepwise transition to higher synchronized states in a random network of phase oscillators”, EPL, 99, 10008. (SCI) (IF: 1.963; SCI ranking: 24.1%)

  • [52]     Nickolay Sh. Izmailiana, Philippe Ruelle*, Chin-Ku Hu*, 2012, “Finite-size Corrections for Logarithmic Representations in Critical Dense Polymers”, Physics Letters B, 711, 71. (SCI) (IF: 4.787; SCI ranking: 25%,22.6%,19%)

  • [53]     Hiroshi Watanabe*, Nobuyasu Ito, and Chin-Kun Hu*, 2012, “Phase diagram and universality of the Lennard-Jones gas-liquid system”, JOURNAL OF CHEMICAL PHYSICS, 136, 204102. (SCI) (IF: 2.894; SCI ranking: 37.5%,25.7%)

  • [54]     David B. Saakian*, Michael W. Deem, Chin-Kun Hu*, 2012, “Finite population size effects in quasispecies model with single-peak fitness landscape”, EPL, 98, 18001. (SCI) (IF: 1.963; SCI ranking: 24.1%)

  • [55]     Ming-Chya Wu*, Mai Suan Li, Wen-Jong Ma, Maksim Kouza, Chin-Kun Hu*, 2011, “Universal geometrical factor of protein conformations as a consequence of energy minimization”, EPL, 96, 68005. (SCI) (IF: 1.963; SCI ranking: 24.1%)

  • [56]     Singh Brajendra K*.; Parham Paul E.; Hu Chin-Kun*, 2011, “Structural Perturbations to Population Skeletons: Transient Dynamics, Coexistence of Attractors and the Rarity of Chaos ”, PLoS One, 6, e24200. (SCI) (IF: 3.057; SCI ranking: 17.5%)

  • [57]     Gevorkian S. G., Allahverdyan A. E.*, Gevorgyan D. S., Hu Chin-Kun, 2011, “ Glassy state of native collagen fibril? ”, EPL, 95, 23001. (SCI) (IF: 1.963; SCI ranking: 24.1%)

  • [58]     Saakian David B.; Biebricher Christof K.; Hu Chin-Kun*, 2011, “ Lethal Mutants and Truncated Selection Together Solve a Paradox of the Origin of Life ”, PLoS One, 6, e21904. (SCI) (IF: 3.057; SCI ranking: 17.5%)

  • [59]     Saakian D. B.*,Martirosyan A.,Hu Chin-Kun, Struzik, ZR , 2011, “Exact probability distribution function for multifractal random walk models of stocks ”, EPL, 95, 28007. (SCI) (IF: 1.963; SCI ranking: 24.1%)

  • [60]     Kirakosyan Zara; Saakian David B*.; Hu Chin-Kun*, 2011, “Finite Genome Length Corrections for the Mean Fitness and Gene Probabilities in Evolution Models ”, JOURNAL OF STATISTICAL PHYSICS, 144, 198-212. (SCI) (IF: 1.537; SCI ranking: 37.7%)

  • [61]     Y.-C. Hung*, C.-K. Hu, 2011, “Constructive Role of Noise in p53 Regulatory Network”, COMPUTER PHYSICS COMMUNICATIONS, 182,249. (SCI) (IF: 3.635; SCI ranking: 10.6%,1.9%)

  • [62]     Karen G. Petrosyan* and Chin-Kun Hu*, 2011, “Protein-mediated Loops and Phase Transition in Nonthermal Denaturation of DNA”, JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT, P01005. (SCI) (IF: 2.091; SCI ranking: 21.5%,15.1%)

  • [63]     J. Busa, S. Hayryan, C.-K. Hu*, J. Skrivanek, M.-C. Wu, 2010, “CAVE: A Package for Detection and Quantitative Analysis of Internal Cavities in a System of Overlapping Balls: Application to Proteins”, COMPUTER PHYSICS COMMUNICATIONS, 181 (12 ) , 2116-2125. (SCI) (IF: 3.635; SCI ranking: 10.6%,1.9%)

  • [64]     Zh. S. Gevorkian*, M. S. Li, C.-K. Hu*, 2010, “Sample to Sample Fluctuations in Heterogeneous DNA”, JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 48 (23) , 2432-2436. (SCI) (IF: 3.318; SCI ranking: 16.5%)

  • [65]     M. S. Li*, N. T. Co, G. Reddy, C. -K. Hu, J. E. Straub, and D. Thirumalai, 2010, “Factors Governing Fibrillogenesis of Polypeptide Chains Revealed by Lattice Models”, PHYSICAL REVIEW LETTERS, 105, 218101. (SCI) (IF: 7.645; SCI ranking: 7.6%)

  • [66]     H. L. Chen, C.-c. Hsu, M.-H. Viet, M. S. Li, C.-K. Hu, C.-H. Liu, F. Luk, E. Chang, A. Wang, M.-F. Hsu; W. Fann, R. Chen, 2010, “Studying the fast folding kinetics of an antifreeze protein RD1 using a photolabile caging strategy and time-resolved photoacoustic calorimetry on a nanosecond timescale, Proteins: Structure, Function, and Bioinformatics”, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 78, 2973-2983. (SCI) (IF: 2.499; SCI ranking: 45.8%,56.4%)

  • [67]     D. N. Klochkov, A. I. Artemyev, K. B. Oganesyan*, Y. V. Rostovtsev, C.-K. Hu , 2010, “Induced Smith-Purcell radiation”, JOURNAL OF MODERN OPTICS, 57 (20), 2060-2068. (SCI) (IF: 1.267; SCI ranking: 62.2%)

  • [68]     W.-J. Ma, C.-K. Hu*, 2010, “Molecular Dynamics Approach to Aggregation of Polymer Chains with Monomers Connected by Springs”, JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, 79, 104002. (SCI) (IF: 1.559; SCI ranking: 39.2%)

  • [69]     H.-Y. Hu, M.-C. Wu, H.-J. Fang, M. D. Forrest, C.-K. Hu, T.-Y. Tsong, H.-M. Chen*, 2010, “The role of tryptophan in staphylococcal nuclease stability”, BIOPHYSICAL CHEMISTRY, 151 (3 ), 170-177. (SCI) (IF: 2.363; SCI ranking: 50%,60.6%,45.8%)

  • [70]     D. N. Klochkov*, A. I. Artemyev, K. B. Oganesyan, Y. V. Rostovtsev, M. O. Scully, C.-K. Hu, 2010, “The dispersion equation of the induced Smith-Purcell instability”, PHYSICA SCRIPTA, T140, 014049. (SCI) (IF: 1.194; SCI ranking: 50.6%)

  • [71]     K. B. Oganesyan*, M. L. Petrosyan, M. V. Fedorov, A. I. Artemiev, Y. V. Rostovtsev, M. O. Scully, G. Kurizki, C.-K. Hu, 2010, “The threshold conditions for an FELWI”, PHYSICA SCRIPTA, T140, 014058. (SCI) (IF: 1.194; SCI ranking: 50.6%)

  • [72]     B. C. Bag, C.-K. Hu, M. S. Li*, 2010, “Colored Noise, Folding Rates and Departure from Kramers’ Behavior”, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 12, 11753-11762. (SCI) (IF: 4.449; SCI ranking: 22.2%,17.1%)

  • [73]     M. K. Sen, B. C. Bag, K. G. Petrosyan, C.-K. Hu*, 2010, “Effect of time delay on the onset of synchronization of the stochastic Kuramoto model”, JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT, P08018. (SCI) (IF: 2.091; SCI ranking: 21.5%,15.1%)

  • [74]     D. Y. Lando, A. S. Fridman, C.-K. Hu*, 2010, “Influence of strongly stabilized sites on DNA melting: A comparison of theory with experiment”, EPL, 91 (3 ), 38003. (SCI) (IF: 1.963; SCI ranking: 24.1%)

  • [75]     Chin-Kun Hu*, Wen-Jong Ma, 2010, “Molecular Dynamics Approach to Relaxation and Aggregation of Polymer Chains”, PROGRESS OF THEORETICAL PHYSICS SUPPLEMENT, 184, 369-384.

  • [76]     D. B. Saakian* , C.-K. Hu, 2010, “ Selection via flatness as a dynamical effect in evolution models with finite population”, Physical Review E, 82, 011902. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [77]     Z. Kirakosyan, D. B. Saakian, Chin-Kun Hu, 2010, “Evolution models with lethal mutations on symmetric or random fitness landscapes”, Physical Review E, 82, 011904. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [78]     D. B. Saakian*, A. S. Martirosyan, C.-K. Hu, 2010, “Different fitnesses for in vivo and in vitro evolutions due to the finite generation-time effect”, Physical Review E, 81, 061913. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [79]     O. S. Rozanova*, J.-L. Yu, Chin-Kun Hu, 2010, “Typhoon eye trajectory based on a mathematical model: comparing with observational data”, NONLINEAR ANALYSIS-REAL WORLD APPLICATIONS, 11, 1847. (SCI) (IF: 2.238; SCI ranking: 3.9%)

  • [80]     Wen-Jong Ma, Chin-Kun Hu*, 2010, “Molecular dynamics approach to aggregation of polymer chains with monomers connected by rigid bonds”, JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, 79, 054001. (SCI) (IF: 1.559; SCI ranking: 39.2%)

  • [81]     Wen-Jong Ma and Chin-Kun Hu*, 2010, “Molecular dynamics approach to aggregation of polymer chains with monomers connected by rigid bonds”, Journal of the Physical Society of Japan, 79, 054001. (SCI) (IF: 1.559; SCI ranking: 39.2%)

  • [82]     Cui-Lian Li*, Chin-Kun Hu, 2010, “Mechanism of morphological transition in heteroepitaxial growth of metal films”, APPLIED PHYSICS LETTERS, 96, 093101. (SCI) (IF: 3.142; SCI ranking: 19.3%)

  • [83]     Wen-Jong Ma, Chin-Kun Hu*, 2010, “ Generalized statistical mechanics and scaling behavior for non-equilibrium polymer chains I: monomers connected by rigid bonds”, Journal of the Physical Society of Japan, 79, 024005. (SCI) (IF: 1.559; SCI ranking: 39.2%)

  • [84]     Wen-Jong Ma, Chin-Kun Hu*, 2010, “Generalized statistical mechanics and scaling behavior for nonequilibrium polymer chains II: monomers connected by springs”, JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, 79, 024006. (SCI) (IF: 1.559; SCI ranking: 39.2%)

  • [85]     M. Kouza, Chin-Kun Hu, H. Zung, M. S. Li*, 2009, “ Protein mechanical unfolding: importance of non-native interactions”, JOURNAL OF CHEMICAL PHYSICS, 131, 215103. (SCI) (IF: 2.894; SCI ranking: 37.5%,25.7%)

  • [86]     M.-C. Wu*, E. Watanabe, Z. R. Struzik, Chin-Kun Hu, 2009, “Phase statistics approach to human ventricular fibrillation”, Physical Review E, 80, 051917. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [87]     David B. Saakian*, Christof K. Biebricher , Chin-Kun Hu, 2009, “Phase diagram for the Eigen quasispecies theory with a truncated fitness landscape ”, PHYSICAL REVIEW E, 79, 041905. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [88]     A. E. Allahverdyan*, Zh. S.Gevorkian, Chin-Kun Hu, Th. M.Nieuwenhuizen, 2009, “How adsorption influences DNA denaturation ”, PHYSICAL REVIEW E, 79, 031903. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [89]     Chung-Ke Chang, Yen-Lan Hsu, Yuan-Hsiang Chang, Fa-An Chao, Ming-Chya Wu,Yu-Shan Huang,Chin-Kun Hu, Tai-Huang Huang*, 2009, “Multiple Nucleic Acid Binding Sites and Intrinsic Disorder of Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein: Implications for Ribonucleocapsid Protein Packaging ”, JOURNAL OF VIROLOGY, 83 ,2255-2264. (SCI) (IF: 4.606; SCI ranking: 15.2%)

  • [90]     Huey-Jen Fang, Yong-Zhong Chen , Mai Suan Li , Ming-Chya Wu, Chun-Ling Chang, Chung-ke Chang, Yen-ian Hsu, Tai-huang Huang , Hueih-Min Chen, Tian-YowTsong , Chin-Kun Hu*, 2009, “Thermostability of the N-Terminal RNA-Binding Domain of the SARS-CoV Nucleocapsid Protein: Experiments and Numerical Simulations”, BIOPHYSICAL JOURNAL, 96, 1892-1901. (SCI) (IF: 3.632; SCI ranking: 25%)

  • [91]     N. Sh.Izmailian *, Chin-Kum Hu, 2009, “Boundary conditions and amplitude ratios for finite-size corrections of a one-dimensional quantum spin model ”, NUCLEAR PHYSICS B, 808 , 613-624. (SCI) (IF: 3.735; SCI ranking: 35.7%)

  • [92]     Bidhan Chandra Bag*, Chin-Kung Hu, 2009, “Current inversion induced by colored non-Gaussian noise ”, JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT, 02003. (SCI) (IF: 2.091; SCI ranking: 21.5%,15.1%)

  • [93]     Jan Busa,Shura Hayryan, Chin-Kun Hu*, Jaroslav Skrivanek, Ming-Chya Wu, 2009, “Enveloping Triangulation Method for Detecting Internal Cavities in Proteins and Algorithm for Computing Their Surface Areas and Volumes ”, JOURNAL OF COMPUTATIONAL CHEMISTRY, 30, 346-357. (SCI) (IF: 3.648; SCI ranking: 25.2%)

  • [94]     A. E. Allahverdyan*; C.-K. Hu, 2009, “Replicators in Fine-grained Environment: Adaptation and Polymorphism”, PHYSICAL REVIEW LETTERS, volume 102, p.058102. (SCI) (IF: 7.645; SCI ranking: 7.6%)

  • [95]     Yao-Chen Hung,Chin-Kun Hu, 2008, “Chaotic Communication via Temporal Transfer Entropy ”, PHYSICAL REVIEW LETTERS, 101 , 244102. (SCI) (IF: 7.645; SCI ranking: 7.6%)

  • [96]     B. K. Singh*, M. Gambhir, C.-K. Hu, 2008, “Quasi-cycles and sensitive dependence on seed values in a class of self-evolving maps”, Chaos Solitons & Fractals, 38 (3), 641-649. (SCI) (IF: 1.611; SCI ranking: 32.1%,29.7%,35.4%)

  • [97]     Brajendra K. Singh*, Manoj Gambhir, Chin-Kun Hu , 2008, “Quasi-cycles and sensitive dependence on seed values in edge of chaos behaviour in a class of self-evolving maps ”, CHAOS SOLITONS & FRACTALS, 38, 641-649. (SCI) (IF: 1.611; SCI ranking: 32.1%,29.7%,35.4%)

  • [98]     Hiroshi Watanabe, Chin-Kun Hu*, 2008, “Mapping functions and critical behavior of percolation on rectangular domains ”, PHYSICAL REVIEW E, 78, 041131. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [99]     Syamal Kumar Dana* , Brajendra K. Singh, Satyabrata Chakraborty, Ram Chandra Yadav, Juergen Kurths , Gregory V. Osipov, Prodyot Kumar Roy ,Chin-Kun Hu, 2008, “MULTISCROLL IN COUPLED DOUBLE SCROLL TYPE OSCILLATORS ”, INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, 18, 2965-2980. (SCI) (IF: 1.355; SCI ranking: 45.5%,34.9%)

  • [100]     C. -Y. Chow, Ming-Chya Wu, Huey-Jen Fang, Chin-Kun Hu ,Hueih-Min Chen,Tian-Yow Tsong*, 2008, “Compact dimension of denatured states of staphylococcal nuclease ”, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 72 , 901-909. (SCI) (IF: 2.499; SCI ranking: 45.8%,56.4%)

  • [101]     Tian-Yow Tsong, Chin-Kun Hu, Ming-Chya Wu, 2008, “Hydrophobic condensation and modular assembly model of protein folding ”, BIOSYSTEMS, 93, 78-89.

  • [102]     David B. Saakian, Zara Kirakosyan , Chin-Kun Hu*, 2008, “Diploid biological evolution models with general smooth fitness landscapes and recombination ”, PHYSICAL REVIEW E, 77 , 061907. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [103]      E. M. Sarkisyan, K. G. Petrosyan, K. B.Oganesyan*, A. A. Hakobyan, V. A. Saakyan , S. G. Gevorkian, N. Sh. Izmailyan, C. K. Hu, 2008, “Detection of Casimir photons with electrons ”, LASER PHYSICS, 18 , 621-624. (SCI) (IF: 1.102; SCI ranking: 69.7%,68.9%)

  • [104]     Maksim Kouza,Chin-Kun Hu, Mai Suan Lia*, 2008, “New force replica exchange method and protein folding pathways probed by force-clamp technique ”, JOURNAL OF CHEMICAL PHYSICS, 128, 045103. (SCI) (IF: 2.894; SCI ranking: 37.5%,25.7%)

  • [105]     Yao-Chen Hung, Y.-T. Huang, M.-C. Ho,, C.-K. Hu*, 2008, “Paths to globally generalized synchronization in scale-free dynamical networks”, Physical Review E, 77, 016202. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [106]     Bidhan Chandra Bag , K. G. Petrosyan,Chin-Kun Hu *, 2007, “Influence of noise on the synchronization of the stochastic Kuramoto model ”, PHYSICAL REVIEW E, 76 , 056210. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [107]     N. Sh.Izmailian, Chin-Kun Hu*, 2007, “Finite-size effects for the Ising model on helical tori ”, PHYSICAL REVIEW E, 76, 041118. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [108]     V. V. Arutyunyan , N. Sh. lzmailyan , K. B. Oganesyan , K. G.Petrosyan, C. K. Hu, 2007, “Laser cooling of electrons and X-ray generation in a relativistic quantum heat engine ”, LASER PHYSICS, 17, 1073-1076. (SCI) (IF: 1.102; SCI ranking: 69.7%,68.9%)

  • [109]      Yevgeni Sh. Mamasakhlisov, Shura Hayryan,V. F.Morozov , Chin-Kun Hu *, 2007, “RNA folding in the presence of counterions ”, PHYSICAL REVIEW E, 75, 061907. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [110]     B. C. Bag, C.-K. Hu*, 2007, “Escape through an unstable limit cycle driven by multiplicative colored non-Gaussian and additive white Gaussian noises”, Phys. Rev. E, 75, 042101. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [111]     Yevgeni Sh. Mamasakhlisov ,Shura Hayryan, Chin-Kun Hu *, 2007, “Random sequences with power-law correlations exhibit proteinlike behavior ”, JOURNAL OF CHEMICAL PHYSICS, 126 ,145103. (SCI) (IF: 2.894; SCI ranking: 37.5%,25.7%)

  • [112]     N. Sh. Izmailian, Vl. V. Papoyan, V. B. Priezzhev, Chin-Kun Hu*, 2007, “Self-organizing behavior in a lattice model for co-evolution of virus and immune system”, Physical Review E, 75, 041104. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [113]     C.-H. Lin, Y.-C. Tsai*, Chin-Kun Hu, 2007, “Wrapping conformations of a polymer on a curved surface”, Physical Review E, 75, 031903. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [114]     R. G. Ghulghazaryan; S. Hayryan; C.-K. Hu*, 2007, “Efficient combination of Wang-Landau and transition matrix Monte Carlo methods for protein simulations ”, JOURNAL OF COMPUTATIONAL CHEMISTRY, volume 28, p.715-p.726. (SCI) (IF: 3.648; SCI ranking: 25.2%)

  • [115]     Chuan-Ji Fu, Bing-Hong Wang*, Chuan-Yang Yin, Tao Zhou, Bo Hu, Kun Gao , P. M. Hui, Chin-Kun Hu , 2007, “Analytical studies on a modified Nagel-Schreckenberg model with the Fukui-Ishibashi acceleration rule ”, CHAOS SOLITONS & FRACTALS, 31, 772-776. (SCI) (IF: 1.611; SCI ranking: 32.1%,29.7%,35.4%)

  • [116]     Mai Suan Li,, Maksim Kouza , Chin-Kun Hu*, 2007, “Refolding upon force quench and pathways of mechanical and thermal unfolding of ubiquitin”, BIOPHYSICAL JOURNAL, 92(2), 547-561. (SCI) (IF: 3.632; SCI ranking: 25%)

  • [117]     E. M. Sarkisyan, K. B. Oganesyan, N. Sh. Izmailian, and C.-K. Hu, 2007, “Graphite cylinder withpulse-periodical sourse of energy for diamond synthesis”, Laser Physics, 17, 1073-1076. (SCI) (IF: 1.102; SCI ranking: 69.7%,68.9%)

  • [118]     Syamal Kumar Dana*, Dipendra Chandra Sengupta, Chin-Kun Hu , 2006, “Spiking and bursting in Josephson junction ”, IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS, 53 ,1031-1034. (SCI) (IF: 1.136; SCI ranking: 55.3%)

  • [119]      Ming-Chya Wu, Cui-Lian Li, Chin-Kun Hu, Yuan-Chih Chang, Yuan-Hong Liaw ,Li-Wei Huang, Chia-Seng Chang,Tien-Tzou Tsong, Tung Hsu , 2006, “Curvature effect on the surface diffusion of silver adatoms on carbon nanotubes: Deposition experiments and numerical simulations ”, PHYSICAL REVIEW B, 74, 125424. (SCI) (IF: 3.718; SCI ranking: 23.9%)

  • [120]     Jun Dai, Chin-Kun Hu, Xiang-Sheng Chu ,Da-Ren He* , 2006, “Unpredictability of iteration destination in an integrate-and-fire circuit ”, CHINESE PHYSICS LETTERS, 23, 2023-2026. (SCI) (IF: 0.875; SCI ranking: 68.4%)

  • [121]      Bidhan Chandra Bag, Chin-Kun Hu *, 2006, “Escape through an unstable limit cycle: Resonant activation”, PHYSICAL REVIEW E, 73, 061107. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [122]     M.-C. Wu, Hu, Chin-Kun*, 2006, “Empirical mode decomposition and cardiorespiratory synchrogram approach to cardiorespiratory synchronization”, Phys. Rev. E, 73, 32767,1-11. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [123]     Saakian DB, Munoz E, Hu CK*, Deem MW, 2006, “Quasispecies theory for multiple-peak fitness landscapes”, PHYSICAL REVIEW E, 73, 041913. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [124]     A.E. Allahverdyan,, Zh.S. Gevorkian,, Hu, Chin-Kun and Th.M. Nieuwenhuizen., 2006, “Adhesion induced DNA naturation”, Phys. Rev. Lett, 96, 32767,1-4. (SCI) (IF: 7.645; SCI ranking: 7.6%)

  • [125]     AE Allahverdyan* , ZS Gevorkian , CK Hu, TM Nieuwenhuizen, 2006, “Adhesion-induced DNA naturation ”, PHYSICAL REVIEW LETTERS, 96 , 098302. (SCI) (IF: 7.645; SCI ranking: 7.6%)

  • [126]     F. Eisenmenger,, U. H.E. Hansmann,, S. Hayryan, Chin-Kun Hu*, 2006, “An enhanced version of SMMP - Open-source software package for simulation of proteins”, COMPUTER PHYSICS COMMUNICATIONS, 174, 422-429. (SCI) (IF: 3.635; SCI ranking: 10.6%,1.9%)

  • [127]      F Eisenmenger, UHE Hansmann, S Hayryan, CK Hu*, 2006, “An enhanced version of SMMP-open-source software package for simulation of proteins ”, COMPUTER PHYSICS COMMUNICATIONS, 174, 422-429. (SCI) (IF: 3.635; SCI ranking: 10.6%,1.9%)

  • [128]     D. B. Saakian; Chin-Kun Hu*, 2006, “Exact solution of the Eigen model with general fitness functions and degradation rates”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, volume 103, p.4935-p.4939. (SCI) (IF: 9.423; SCI ranking: 6.3%)

  • [129]     P. M. Gade and Hu, Chin-Kun, 2006, “Scaling and universality in transition to synchronous chaos with local-global interactions”, Phys. Rev. E, 73, 32767,1-11. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [130]     R. E. Amritkar and Hu, Chin-Kun, 2006, “Synchronized state of coupled dynamics on time-varying net-works”, Chaos, 16, 15117. (SCI) (IF: 2.049; SCI ranking: 6.7%,18.9%)

  • [131]      RE Amritkar*, CK Hu, 2006, “Synchronized state of coupled dynamics on time-varying networks ”, CHAOS, 16, 015117. (SCI) (IF: 2.049; SCI ranking: 6.7%,18.9%)

  • [132]     M Kouza ,MS Li, EP O'Brien ,CK Hu, D Thirumalai, 2006, “Effect of finite size on cooperativity and rates of protein folding ”, JOURNAL OF PHYSICAL CHEMISTRY A, 110, 671-676.

  • [133]     N. Sh. Izmailian,*, K. B. Oganesyan,, M.-C. Wu and Hu, Chin-Kun, 2006, “Finite-size corrections and scaling for the triangular lattice dimer model with periodic boundary conditions”, Phys. Rev. E, 73, 16128,1-9. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [134]     MS Li, CK Hu, DK Klimov , D Thirumalai*, 2006, “Multiple stepwise refolding of immunoglobulin domain I27 upon force quench depends on initial conditions ”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103, 93-98. (SCI) (IF: 9.423; SCI ranking: 6.3%)

  • [135]     Li MS, Hu CK, Klimov DK, Thirumalai D*, 2006, “Multiple stepwise refolding of immunoglobulin domain I27 upon force quench depends on initial conditions”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103, 93-98. (SCI) (IF: 9.423; SCI ranking: 6.3%)

  • [136]      H Watanabe, CK Hu, 2005, “Comment on "superscaling of percolation on rectangular domains" - Reply ”, PHYSICAL REVIEW LETTERS, 95, 258902. (SCI) (IF: 7.645; SCI ranking: 7.6%)

  • [137]      PH Nguyen*, G Stock, E Mittag , CK Hu, MS Li, 2005, “Free energy landscape and folding mechanism of a beta-hairpin in explicit water: A replica exchange molecular dynamics study ”, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 61, 795-808. (SCI) (IF: 2.499; SCI ranking: 45.8%,56.4%)

  • [138]     NS Izmailian , VB Priezzhev, P Ruelle, CK Hu*, 2005, “Logarithmic conformal field theory and boundary effects in the dimer model ”, PHYSICAL REVIEW LETTERS, 95 ,260602. (SCI) (IF: 7.645; SCI ranking: 7.6%)

  • [139]      M Kouza, CF Chang , S Hayryan, TH Yu,MS Li ,TH Huang , CK Hu*, 2005, “Folding of the protein domain hbSBD ”, BIOPHYSICAL JOURNAL, 89, 3353-3361. (SCI) (IF: 3.632; SCI ranking: 25%)

  • [140]     C.-J. Fu,, B.-H. Wang,*, C.-Y. Yin,, T. Zhou,, K. Gao,, P. M. Hui, and Hu, Chin-Kun, 2005, “Analytical Studies on a Modified Nagel-Schreckenberg Model with the Fukui-Ishibashi Acceleration Rule”, Chaos Solitons & Fractals, 31, 772-776. (SCI) (IF: 1.611; SCI ranking: 32.1%,29.7%,35.4%)

  • [141]     YB Xie,BH Wang*, CK Hu, T Zhou, 2005, “Global optimization of minority game by intelligent agents”, EUROPEAN PHYSICAL JOURNAL B, 47(4), 587-593. (SCI) (IF: 1.223; SCI ranking: 70.1%)

  • [142]     Maksim Kouza,, Mai Suan Li,, Edward P. Obrien,, Hu, Chin-Kun and D. Thirumalai., 2005, “Effect of finite size on cooperativity and rates of protein folding”, J. Phys. Chem. A, 110, 671-676. (SCI) (IF: 2.883; SCI ranking: 38.2%,31.4%)

  • [143]     S Jalan , RE Amritkar*, CK Hu, 2005, “Synchronized clusters in coupled map networks. I. Numerical studies ”, PHYSICAL REVIEW E, 72, 016211. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [144]      RE Amritkar*, S Jalan, CK Hu, 2005, “Synchronized clusters in coupled map networks. II. Stability analysis ”, PHYSICAL REVIEW E, 72, 016212. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [145]     EV Ivashkevich , CK Hu*, 2005, “Exact multileg correlation functions for the dense phase of branching polymers in two dimensions ”, PHYSICAL REVIEW E, 71, 015104. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [146]     S Hayryan , CK Hu , J Skrivanek , E ayryan, I Pokorny, 2005, “A new analytical method for computing solvent-accessible surface area of macromolecules and its gradients ”, JOURNAL OF COMPUTATIONAL CHEMISTRY, 26,334-343.

  • [147]     Hayryan S, Hu CK and Skrivanek J et al., 2005, “A new analytical method for computing solvent-accessible surface area of macromolecules and its gradients”, JOURNAL OF COMPUTATIONAL CHEMISTRY, 26(4), 334-343. (SCI) (IF: 3.648; SCI ranking: 25.2%)

  • [148]      VF Morozov*, ES Mamasakhlisov, AV Grigoryan, AV Badasyan , S Hayryan, CK Hu, 2005, “Helix-coil transition in closed circular DNA ”, PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 348 , 327-338. (SCI) (IF: 1.785; SCI ranking: 29.1%)

  • [149]      J Busa, J Dzurina, E Hayryan,S Hayryan , CK Hu, J Plavka, I Pokorny, JcSkrivanek , MC Wu , 2005, “ARVO: A Fortran package for computing the solvent accessible surface area and the excluded volume of overlapping spheres via analytic equations”, COMPUTER PHYSICS COMMUNICATIONS, 165, 59-96. (SCI) (IF: 3.635; SCI ranking: 10.6%,1.9%)

  • [150]     Ivashkevich EV , CK Hu*, 2005, “Exact multileg correlation functions for the dense phase of branching polymers in two dimensions”, PHYSICAL REVIEW E, 71, 015104. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [151]      H Watanabe, S Yukawa , N Ito, CK Hu*, 2004, “Superscaling of percolation on rectangular domains ”, PHYSICAL REVIEW LETTERS, 93 , 190601. (SCI) (IF: 7.645; SCI ranking: 7.6%)

  • [152]     D. B. Saakian, C.-K. Hu *, H. Khachatryan, 2004, “Solvable biological evolution models with general fitness functions and multiple mutations in parallel mutation-selection scheme”, Phys. Rev. E, 70, 041908. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [153]     DB Saakian , CK Hu*, H Khachatryan, 2004, “Solvable biological evolution models with general fitness functions and multiple mutations in parallel mutation-selection scheme”, PHYSICAL REVIEW E, 70 ,041908. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [154]     Ma WJ, CK Hu *, RE Amritkar , 2004, “Stochastic dynamical model for stock-stock correlations”, PHYSICAL REVIEW E, 70, 026101. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [155]      CK Hu , Ou-Yang ZC, Hu B, Wang BH , 2004, “ Progress in Statistical and Nonlinear Physics: Proceedings of the first cross Taiwan-strait Conference on Statistical Physics Yangzhou, China - 26-31 August 2003 - Preface ”, INTERNATIONAL JOURNAL OF MODERN PHYSICS B, 18,V-VIII. (SCI) (IF: 0.85; SCI ranking: 80.6%,66%,80%)

  • [156]      AE Allahverdyan*, ZS Gevorkian , CK Hu, MC Wu, 2004, “Unzipping of DNA with correlated base sequence ”, PHYSICAL REVIEW E, 69, 061908. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [157]     D. B. Saakian , C.-K. Hu.*, 2004, “Solvable biological evolution model with parallel mutation-selection scheme”, Phys. Rev. E, 69, 046121. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [158]     D Saakian , CK Hu*, 2004, “Eigen model as a quantum spin chain: Exact dynamics ”, PHYSICAL REVIEW E, 69 , 021913. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [159]      Z Usatenko , CK Hu, 2003, “Crossover between special and ordinary transitions in random semi-infinite Ising-like systems ”, PHYSICAL REVIEW E, 68 , 066115. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [160]     Usatenko Z* , Hu CK, 2003, “Crossover between special and ordinary transitions in random semi-infinite Ising-like systems”, PHYSICAL REVIEW E, 68((6): Art. No. 066115 Part 2). (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [161]      AM Povolotsky, VB Priezzhev, CK Hu , 2003, “Transition from Kardar-Parisi-Zhang to tilted interface critical behavior in a solvable asymmetric avalanche model ”, PHYSICAL REVIEW LETTERS, 91, 255701. (SCI) (IF: 7.645; SCI ranking: 7.6%)

  • [162]     Povolotsky AM, Priezzhev VB and Hu CK, 2003, “Transition from Kardar-Parisi-Zhang to tilted interface critical behavior in a solvable asymmetric avalanche model”, PHYSICAL REVIEW LETTERS, 91((25): Art. No. 255701). (SCI) (IF: 7.645; SCI ranking: 7.6%)

  • [163]     Yang WS, Wang BH, Quan HJ , CK Hu , 2003, “Strategy uniform crossover adaptation evolution in a minority game ”, CHINESE PHYSICS LETTERS, 20 , 1659-1661. (SCI) (IF: 0.875; SCI ranking: 68.4%)

  • [164]     CY Lin , CK Hu, UHE Hansmann, 2003, “Parallel tempering simulations of HP-36 ”, PROTEINS-STRUCTURE FUNCTION AND GENETICS, 52, 436-445.

  • [165]     Lin CY, Hu CK and Hansmann UHE*, 2003, “Parallel tempering simulations of HP-36”, PROTEINS-STRUCTURE FUNCTION AND GENETICS, 52(3), 436-445.

  • [166]     NS Izmailian , KB Oganesyan, CK Hu , 2003, “Exact finite-size corrections of the free energy for the square lattice dimer model under different boundary conditions ”, PHYSICAL REVIEW E, 67, 066114. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [167]     Izmailian NS, Oganesyan KB, Hu CK*, 2003, “Exact finite-size corrections of the free energy for the square lattice dimer model under different boundary conditions”, PHYSICAL REVIEW E, 67((6): Art. No. 066114 Part 2). (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [168]     AM Povolotsky , VB Priezzhev , CK Hu, 2003, “The asymmetric avalanche process ”, JOURNAL OF STATISTICAL PHYSICS, 111, 1149-1182. (SCI) (IF: 1.537; SCI ranking: 37.7%)

  • [169]     Povolotsky AM*, Priezzhev VB, Hu CK, 2003, “The asymmetric avalanche process”, JOURNAL OF STATISTICAL PHYSICS, 111(5-6), 1149-1182. (SCI) (IF: 1.537; SCI ranking: 37.7%)

  • [170]      MC Wu, CK Hu , NS Izmailian, 2003, “Universal finite-size scaling functions with exact nonuniversal metric factors ”, PHYSICAL REVIEW E, 67, 065103. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [171]     Wu MC, Hu CK* and Izmailian NS, 2003, “Universal finite-size scaling functions with exact nonuniversal metric factors”, PHYSICAL REVIEW E, 67((6): Art. No. 065103 Part 2). (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [172]     NS Izmailian , KB Oganesyan ,CK Hu , 2003, “Exact finite-size corrections for the square-lattice Ising model with Brascamp-Kunz boundary conditions ”, PHYSICAL REVIEW E, 65, 056132. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [173]      AM Povolotsky, VB Priezzhev , CK Hu, 2003, “Finite size behavior of the asymmetric avalanche process ”, PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 321, 280-285. (SCI) (IF: 1.785; SCI ranking: 29.1%)

  • [174]     Povolotsky AM*, Priezzhev VB, Hu CK, 2003, “Finite size behavior of the asymmetric avalanche process”, PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 321(1-2), 280-285. (SCI) (IF: 1.785; SCI ranking: 29.1%)

  • [175]     YH Shiau , YF Peng , YC Cheng,CK Hu , 2003, “Multistability and chaos in a semiconductor microwave device with time-delay feedback ”, JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, 72, 801-804. (SCI) (IF: 1.559; SCI ranking: 39.2%)

  • [176]      CK Hu, CY Lin , 2003, “Universality in critical exponents for toppling waves of the BTW sandpile model on two-dimensional lattices ”, PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 318 , 92-100. (SCI) (IF: 1.785; SCI ranking: 29.1%)

  • [177]     Hu CK* , Lin CY, 2003, “Universality in critical exponents for toppling waves of the BTW sandpile model on two-dimensional lattices”, PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 318(1-2), 92-100. (SCI) (IF: 1.785; SCI ranking: 29.1%)

  • [178]      S Hayryan, CK Hu, E Hayryan , I Pokorny, 2003, “Parallel solution of the Poisson-Boltzmann equation for proteins ”, COMPUTATIONAL SCIENCE - ICCS 2003, PT I, PROCEEDINGS, 2657, 54-62.

  • [179]     Hayryan S, Hu CK and Hayryan E et al., 2003, “Parallel solution of the Poisson-Boltzmann equation for proteins”, LECTURE NOTES IN COMPUTER SCIENCE, 2657, 54-62.

  • [180]      D Mao,BH Wang , L Wang, PM Hui, CK Hu, 2003, “Traffic flow CA model in which only the cars following the trail of the ahead car can be delayed ”, INTERNATIONAL JOURNAL OF NONLINEAR SCIENCES AND NUMERICAL SIMULATION, 4, 239-250. (SCI) (IF: 0.687; SCI ranking: 83%,65.9%,85.9%,62.2%)

  • [181]     CY Lin , CK Hu, 2002, “Renormalization-group approach to an Abelian sandpile model on planar lattices ”, PHYSICAL REVIEW E, 66, 021307. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [182]     EV Ivashkevich ,NS Izmailian , CK Hu, 2002, “Kronecker's double series and exact asymptotic expansions for free models of statistical mechanics on torus ”, JOURNAL OF PHYSICS A-MATHEMATICAL AND GENERAL, 35 , 5543-5561.

  • [183]     Z Usatenko , CK Hu , 2002, “Critical behavior of semi-infinite random systems at the special surface transition ”, PHYSICAL REVIEW E, 65, 066103. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [184]      MC Wu, CK Hu , 2002, “Exact partition functions of the Ising model on M x N planar lattices with periodic-aperiodic boundary conditions ”, JOURNAL OF PHYSICS A-MATHEMATICAL AND GENERAL, 35 , 5189-5206.

  • [185]      M Weigel, W Janke, CK Hu, 2002, “ Random-cluster multihistogram sampling for the q-state Potts model”, PHYSICAL REVIEW E, 65, 036109.

  • [186]      NS Izmailian, CK Hu , 2002, “Exact amplitude ratio and finite-size corrections for the M X N square lattice Ising model ”, PHYSICAL REVIEW E, 65, 036103.

  • [187]     CK Hu, 2002, “Low temperature properties of a spin model with varying ferromagnetic and antiferromagnetic couplings ”, NEW KINDS OF PHASE TRANSITIONS: TRANSFORMATIONS IN DISORDERED SUBSTANCES Book Series: NATO SCIENCE SERIES, SERIES II: MATHEMATICS, PHYSICS AND CHEMISTRY, 81,633-641.

  • [188]     YH Shiau , CK Hu , 2001, “Pattern competition in the photorefractive semiconductors”, JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, 70, 3636-3640. (SCI) (IF: 1.559; SCI ranking: 39.2%)

  • [189]      CY Lin, CK Hu, UHE Hansmann, 2001, “Proteinlike behavior of a spin system near the transition between a ferromagnet and a spin glass”, PHYSICAL REVIEW E, 64, 052903.

  • [190]     YC Tsai , CK Hu, 2001, “Generalized antiferromagnetic Heisenberg spin ladders”, PHYSICA B-CONDENSED MATTER, 305, 21-37.

  • [191]     S. Hayryan, C.-K. Hu, S.-Y. Hu ,R.-J. Shang, 2001, “ Multicanonical parallel simulations of proteins with continuous potentials ”, JOURNAL OF COMPUTATIONAL CHEMISTRY, 22, 1287-1296. (SCI) (IF: 3.648; SCI ranking: 25.2%)

  • [192]     V.B. Priezzhev, E.V. Ivashkevich, A.M. Povolotsky, C.-K. Hu, 2001, “ Exact phase diagram for an asymmetric avalanche process”, PHYSICAL REVIEW LETTERS, 87, 084301. (SCI) (IF: 7.645; SCI ranking: 7.6%)

  • [193]     F. Eisenmenger, U.H.E. Hansmann, S. Hayryan,C.-K. Hu, 2001, “ [SMMP] A modern package for simulation of proteins”, COMPUTER PHYSICS COMMUNICATIONS, 138, 192-212.

  • [194]     H. Watanabe, S. Yukawa, N. Ito, C.-K. Hu, C.-Y. Lin,W.-J. Ma, 2001, “ Polydispersity effect and universality of finite-size scaling function”, JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, 70, 1537-1542. (SCI) (IF: 1.559; SCI ranking: 39.2%)

  • [195]      HP Hsu, SC Lin , CK Hu, 2001, “Universal scaling functions for bond percolation on planar-random and square-lattices with multiple percolating clusters”, PHYSICAL REVIEW E, 64, 016127. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [196]     Z.E. Usatenko, M.A. Shpot, C.-K. Hu, 2001, “ Surface critical behavior of random systems: Ordinary transition”, PHYSICAL REVIEW E, 63, 056102.

  • [197]     NS Izmailian , CK Hu, 2001, “Exact universal amplitude ratios for two-dimensional Ising models and a quantum spin chain”, PHYSICAL REVIEW LETTERS, 86, 5160-5163.

  • [198]      A Silchenko, CK Hu, 2001, “Multifractal characterization of stochastic resonance”, PHYSICAL REVIEW E, 63, 041105. (SCI) (IF: 2.252; SCI ranking: 11.3%,33.3%)

  • [199]     ZS Gevorkian , CP Chen, CK Hu, 2001, “New mechanism of x-ray radiation from a relativistic charged particle in a dielectric random medium”, PHYSICAL REVIEW LETTERS, 86, 3324-3327.

  • [200]     C.-K. Hu, E. V. Ivashkevich, C.-Y. Lin, V.B. Priezzhev, 2000, “ Inversion symmetry and exact critical exponents of dissipating waves in the sandpile model”, PHYSICAL REVIEW LETTERS, 85, 4048-4051. (SCI) (IF: 7.645; SCI ranking: 7.6%)

  • [201]     PM Gade , CK Hu , 2000, “Synchronous chaos in coupled map lattices with small-world interactions”, PHYSICAL REVIEW E, 62, 6409-6413.

  • [202]     CP Chen , ZS Gevorkian,CK Hu , 2000, “ X-ray radiation from a relativistic charge in super-conducting granule device by diffusional scattering of pseudophotons”, PHYSICA A, 281, 450-462.

  • [203]     Y. Okabe, K. Kaneda, Y. Tomita, M. Kikuchi, C.-K. Hu, 2000, “Cluster analysis of the Ising model and universal finite-size scaling”, PHYSICA A, 281, 233-241. (SCI) (IF: 1.785; SCI ranking: 29.1%)

  • [204]     JR Roan ,CK Hu , 2000, “Crossover from the hydrodynamic regime to the thermal fluctuation regime in a two-dimensional phase-separating binary fluid containing surfactants”, PHYSICAL REVIEW E, 62, 766-774.

  • [205]     V.F. Morozov, E.S. Mamasakhlisov, S. Hayryan, C.-K. Hu, 2000, “Microscopical approach to the helix-coil transition in DNA ”, PHYSICA A, 281, 51-59. (SCI) (IF: 1.785; SCI ranking: 29.1%)

  • [206]     S.-Y. Kim, R.J. Creswick, C.-N. Chen, C.-K. Hu, 2000, “Partition function zeros of the Q-state Potts model for non-integer Q”, PHYSICA A, 281, 262-267. (SCI) (IF: 1.785; SCI ranking: 29.1%)

  • [207]      CK Hu, KT Leung, 2000, “StatPhys-Taiwan-1999: Equilibrium and Non-Equilibrium Phase Transitions - Proceedings of the Fifth Taiwan International Symposium on Statistical Physics, held at Institute of Physics, Academia Sinica, Taipei, 9-12 August 1999 and at Department of Physics, National Dong Hwa University, Hualien, 12-16 August 1999 - Preface”, PHYSICA A, 281, XV-XVI. (SCI) (IF: 1.785; SCI ranking: 29.1%)

  • [208]     H.-C. Tseng, P.-R. Huang, H.-J. Chen, C.-K. Hu, 2000, “The diffusion behavior of a simple map with periodic quenched disorder ”, PHYSICA A, 281, 323-336.

  • [209]     C.-K. Hu, J.-A. Chen, N.Sh. Izmailian, P. Kleban, 2000, “: Recent developments in the Monte Carlo approach to percolation problems”, COMPUTER PHYSICS COMMUNICATIONS, 126, 77-81. (SCI) (IF: 3.635; SCI ranking: 10.6%,1.9%)

  • [210]      NS Izmailian, CK Hu, FY Wu , 2000, “The 6-vertex model of hydrogen-bonded crystals with bond defects ”, JOURNAL OF PHYSICS A-MATHEMATICAL AND GENERAL, 33, 2185-2193.

學術會議(研討會)論文

  • [1]     Yu-Hsin Hsieh, Chi-Ning Chen*, and Chin-Kun Hu*, 2015, “Exact partition functions of interacting self-avoiding walks on lattices”, EPJ Web of Conferences 108, 01005 (2016) pages, paper presented at International Conference on Mathematical Modelling and Computational Physics 2015 (MMCP 2015), Stara Lesna, Slovakia: Technical University of Kosice, 2015-07-13 ~ 2015-07-17.

  • [2]     Chin-Kun HU*, 2014, “Protein aggregation and human diseases”, Journal of Physics: Conference Series 604, 012009 (2015) pages, paper presented at The 4th International Workshop on Statistical Physics and Mathematics for Complex Systems (SPMCS2014), Yichang, China: Central China Normal University, 2014-10-13 ~ 2014-10-16.

  • [3]     Chin-Kun Hu*, 2012, “Slow Dynamics in Proteins and Polymer Chains”, AIP Conf. Proc. 1518, 541-550 (2013) pages, paper presented at The 4th International Symposium on Slow Dynamics in Complex Systems, Sendai, Japan: Tohoku University, 2012-12-02 ~ 2012-12-07.

  • [4]     Y.-C. Hung and C.-K. Hu, 2007, “Detecting essential nodes in complex networks from measured noisy time series”, 589-594 pages, paper presented at AIP Conference Proceedings 922, Tokyo: University of Tokyo, 2007-09-09 ~ 2007-09-14.

  • [5]     C.-K. Hu, 2007, “Quantum and lattice modles of biological evolution”, paper presented at AIP Conference Proceedings 922, Tokyo: University of Tokyo, 2007-09-09 ~ 2007-09-14.

  • [6]     M.-C. Wu, Z. R. Struzik, E. Watanabe, Y. Yamamoto, and C.-K. Hu, 2007, “Temporal evolution for the phase histogram of ECG during human ventricular brillation”, 573-576 pages, paper presented at AIP Conference Proceedings 922, New York: University of Tokyo, 2007-09-09 ~ 2007-09-14.

  • [7]     M.-C. Wu and C.-K. Hu., 2007, “Application of empirical mode decomposition to cardiorespiratory synchronization”, paper presented at International workshop on complex dynamics of physio¬logical systems: from heart to brain, Kolkata, INDIA: Indian Institute of Chemical Biology, 2007-02-12 ~ 2007-02-14.

專書

專書著作

主編之專書

  • [1]      Chin-Kun Hu, K.T. Leung and Ming-Chya Wu, 2005, Biologically motivated statistical physics and related problems - Proceedings of the 7th Taiwan International Symposium on Statistical Physics, 162 pages, Holland: North-Holland.

  • [2]     Chin-Kun Hu, Z.-C. Ou-Yang, B. Hu, and B.-H. Wang, 2004, Progress in Statistical and Nonlinear Physics: Proceedings of the First Cross Taiwan-strait Conference on Statistical Physics, 409 pages, Singapore: World-Scientific.

  • [3]     Chin-Kun Hu, K.-T. Leung, 2003, Lattice models and complex systems - Proceedings of the 2nd APCTP and 6th Taiwan International Symposium on Statistical Physics, 380 pages, Holland: North-Holland.

  • [4]     Chin-Kun Hu, K.-t. Leung, 2000, Equilibrium and Non-Equilibrium Phase Transitions - Proceedings of the Fifth Taiwan International Symposium on Statistical Physics, 469 pages, Holland: North-Holland.

  • [5]     Chin-Kun Hu, K.-T. Leung, 1998, New Directions in Statistical Physics - Proceedings of the First Asia-Pacific and the Fourth Taipei International Workshop and Symposium on Statistical Physics, 332 pages, Holland: North-Holland.

  • [6]     Chin-Kun Hu, K.-T. Leung, 1995, PROCEEDINGS OF THE 2ND IUPAP TOPICAL CONFERENCE AND THE 3RD TAIPEI INTERNATIONAL-SYMPOSIUM ON STATISTICAL PHYSICS, 388 pages, Holland: North-Holland.

  • [7]     Chin-Kun Hu and K.-T. Leung, 1994, ORDER-DISORDER TRANSITIONS AND CRITICALITY - PROCEEDINGS OF THE 1ST IUPAP TOPICAL CONFERENCE AND THE 2ND TAIPEI INTERNATIONAL-SYMPOSIUM ON STATISTICAL PHYSICS, 485 pages, Holland: North-Holland.

  • [8]     Chin-Kun Hu, 1992, Computer Aided Statistical Physics, AIP Conference Proceedings 248, 279 pages, New York: American Institute of Physics.

  • [9]     Chin-Kun Hu, 1988, Progress in Statistical Physics:Progress in statistical mechanics: proceedings of the 1986 summer school and the 1088 Workshop, 408 pages, Singapore: World-Scientific.

專書內之論文

技術報告

其他論文

獎項及殊榮

(1) 國內學術研究獎項 2005-10 教育部第49屆學術獎
(2) 國內學術研究獎項 1995, 1996, 1997, 1998, 1999, 國科會特約研究計劃主持人
(3) 國內學術研究獎項 1993, 1994, 1995 國科會傑出研究獎
(4) 國內學術研究獎項 1989-11 吳三連自然科科學獎
(5) 國內學術研究獎項 1989, 1990, 1991 國科會傑出研究獎
(6) 國內學術研究獎項 1987, 1988, 1989 國科會傑出研究獎
(7) 國內學術研究獎項 1985, 1986, 1987 國科會傑出研究獎

發現與突破

(1) 西元年:2010
研究人員(中):胡進錕
研究人員(英):HU, CHIN-KUN, M. S. Li, N. T. Co, G. Reddy, J. E. Straub, and D. Thirumalai
研究成果名稱(中):影響蛋白質群集現象的關鍵因素
研究成果名稱(英):Key Factors for Protein Aggregation
簡要記述(中):胡進錕博士與合作者研究蛋白質群集現象最近有突破性的進展。他們發現影響蛋白質群集現象的關鍵因素,研究論文已經刊於”物理評論通訊(Physical Review Letters, 簡稱PRL)”與”日本物理學會期刊(Journal of the Physical Society of Japan, 簡稱JPSJ)”。這些發現可望有助於揭開蛋白質群集現象的神秘面紗,為預防或治療神經退化性疾病開了一扇希望之門。

神經退化性疾病是指神經結構和功能逐步喪失而造成的疾病,包括阿茲海默症(Alzheimer's disease, 簡稱AD),巴金森症(Parkinson's disease,簡稱PD,也稱為震顫麻痺綜合症),杭丁頓舞蹈症(Huntington's disease,簡稱HD),小腦脊髓萎縮症(Spinocerebellar Atrophy),額顳葉退化症(Frontotemporal lobar degeneration,簡稱FTLD-U)等。這些疾病源於蛋白質在腦部發生群集現象而造成腦神經退化或死亡。例如:AD乃源自蛋白質Aβ40(含40個胺基酸)和Aβ42(含42個胺基酸)群集現象。而HD和小腦脊髓萎縮症乃源自 PolyQ蛋白質(包含許多穀氨醯胺的蛋白質)的群集現象。瞭解造成蛋白質群集現象的關鍵因素是學術上和神經醫學上極重要的問題。

在一篇與波蘭、美國和越南研究人員合作而於2010年11月19日,發表於PRL論文中,胡進錕博士和合作者用晶格模型研究影響群集速率的關鍵因素。他們發現可以由計算單獨一條蛋白質出現在群集形態的機率,決定該蛋白質最容易產生群集現象的溫度。他們也發現群集時間與蛋白質上正負電荷作用強度的相關性,此一發現與實驗數據相符。

在另四篇與國立政治大學應用物理研究所助理教授馬文忠博士合作而於2010年二月、五月和十月發表於JPSJ的論文中,胡博士和馬博士用分子動力學模擬蛋白質的簡化模型在各種情況下的鬆弛和群集現象。他們發現影響群集現象的關鍵因素是和彎曲角(bending angle) 和雙面角(torsion angle)有關的作用力。當二者都是0或是很小時,蛋白質就容易形成群集現象。此一結果可以解釋何以Aβ40和Aβ42會產生群集現象。


簡要記述(英):Dr. Chin-Kun Hu and his collaborators have made a breakthrough discovery about key factors for protein aggregation. The research results have been published in a series of papers at Physical Review Letters (PRL) and Journal of the Physical Society of Japan (JPSJ). Such results are useful for uncovering the mystery of protein aggregation and opening an avenue to guard against or cure neurodegenerative diseases.

Neurodegenerative diseases include Alzheimer's disease (AD),Parkinson's disease (PD), Huntington's disease (HD),Spinocerebellar Atrophy,Frontotemporal lobar degeneration (FTLD-U), etc. Such diseases are due to progressive loss of structure or function of neurons, including death of neurons caused by protein aggregation. For example, AD is considered to be related to aggregation of Aβ40 (protein with 40 amino acids) and Aβ42 (protein with 42 amino acids) and HD and Spinocerebellar Atrophy are related to aggregation of PolyQ (protein with a long sequence of glutamine). Understanding the conditions and mechanism of protein aggregation is a very important academic and biomedical research problem.

In a paper published at PRL on 19 November 2010, Dr. Hu and collaborators at Poland, Vietnam and USA used a lattice model to study the aggregation rates of proteins. They found that the probability for a protein sequence to appear in the conformation of the aggregated state can be used to determine the temperature at which proteins can aggregate most easily. They also found a correlation between aggregation time and the strength of interactions between charged amino acids, which is consistent with experimental observation.

In a series of four papers published in JPSJ in February, May and October 2010, Dr. Wen-Jong Ma (now at Graduate Institute of Applied Physics, National Chengchi University, Taipei) and Dr. Hu used molecular dynamics to study relaxation and aggregation of protein chains under various conditions. They found that when the bending-angle dependent and torsion-angle dependent interactions are zero or very small, then protein chains tend to aggregate at lower temperatures. Such result is useful for understanding aggregation of Aβ40 and Aβ42.

主要相關著作:
M. S. Li*, N. T. Co, G. Reddy, C. -K. Hu, J. E. Straub, and D. Thirumalai, 2010, “Factors Governing Fibrillogenesis of Polypeptide Chains Revealed by Lattice Models”, PHYSICAL REVIEW LETTERS, 105, 218101. (SCI) (IF: 7.645; SCI ranking: 7.6%)
(2) 西元年:2009
研究人員(中):胡進錕
研究人員(英):HU, CHIN-KUN, Armen Allahverdyan
研究成果名稱(中):物理所胡進錕研究員提出新理論 解釋生物多形現象及同域物種形成
研究成果名稱(英):Researchers from Taiwan and Armenia Propose New Theory of Polymorphism and Sympatric Speciation
簡要記述(中):世界上的生物擁有變化萬千的多樣性面貌,即使同種生物外形上也有多樣變化, 這是自然界多采多姿的關鍵。正如同人類血型有O型、A型、B型和AB型,小樹林蝸牛(Grove snail,學名 Cepaea Nemoralist)也有褐、黃、粉紅等不同顏色。而對生物學家來說,這種多形現象(polymorphism)不僅有趣,更具有生物演化的重要學術意涵。因為這些呈現多形的生物可能有相同基因體(如雌雄鱷魚基因體相同);也可能有不同的基因體(如雌雄哺乳類動物基因體不同)。這些都與物種為求適應環境,試圖存活下去,息息相關。

生物學家同時也發現,環境 ( environment ) 是促使同一物種(species)發展多形(morph)的非常重要因素。例如,在春天時與環境顏色相近的褐、粉紅色小樹林蝸牛,不易被獵食,容易存活,而夏、秋天,黃色小樹林蝸牛則存活較多。時序與環境的變化,如何影響多形現象是非常吸引人的學術問題。

本院物理所胡進錕教授與亞美尼亞葉里溫物理研究所的 Armen Allahvendyan 教授,2人共同於2009年2月6日在頂尖物理學專業期刊「物理評論通訊」(Physical Review Letters 102,058102) 發表一篇論文,指出隨時間精細週期變化的環境(fine-grained time-periodic environment)有可能讓原來居於劣勢的物種型態(morph)存活下來,而造成多形現象,這有利於該物種的繁衍。本理論與一項微生物族群的實驗結果相符。

胡進錕研究員解釋,隨時間精細週期變化的環境是指在一生物體的生命期中,環境已有數個週期的變化。例如,小樹林蝸牛生命期約7至8年,它在生命期中經歷7至8次四季的變化,因此它可感受到精細週期變化的環境。胡進錕研究員與Armen Allahvendyan 教授應用演化博弈理論(evolutionary game theory)和Kapiza法(P.L. Kapiza 1894~1984,得1978年諾貝爾物理獎) 研究各種形態生物總數隨時間變化的現象而獲得先前所說的結論。


簡要記述(英):The impact of the environment on adaptation, selection, and evolution is an important subject of biological research. The main mechanism by which adaptation occurs on the population level is by polymorphism and consequently mechanisms of polymorphism attract much attention in various scientific communities, from fields as diverse as ecology, population genetics and biology. On 6 February, 2009, Dr. Armen Allahverdyan of the Yerevan Physics Institute, Yerevan, Armenia and Dr. Chin-Kun Hu of the Institute of Physics published a new theory of polymorphism and sympatric speciation in a leading international physics journal, Physical Review Letters. The article explored a new mechanism of polymorphism related to the influence of a fast, time-dependent (fine-grained) environment. Polymorphism is the term used for two or more clearly different types of phenotype (morphs) that exist in one interbreeding population. One of the most well-known and vivid examples of polymorphism are the human ABO blood groups. Humans with four different blood groups – A, B, AB and O live in one population. The origin of this environmentally-driven polymorphism is related to periodically appearing epidemics of cholera. In normal (cholera-free) periods the O group has a physiological advantage over all other groups, but the other three groups, especially the AB group, are more resistant to cholera. In the context of the current theory 'fast' means that the environment can change many times during an individual's life-time. For example a Grove snail (Cepaea Nemoralist) which lives 7-8 years can experience many seasonal changes. Up until now such a fine-grained environment was not viewed as a potential source of polymorphism, as according to generally accepted common-sense among biologists, individuals exist in an average, static environment, and thus adapt to it. Up until now time-dependence was not considered. However, Allahverdyan and Hu discovered that under certain conditions, weak morphs (i.e., certain groups within the population) can compete and survive in the struggle with strong morphs, since they adjust more flexibly to their time-varying environment, thereby creating a polymorphic state. Moreover, the researchers show that overall fitness during the establishment of this polymorphism can decrease. Paradoxical as it seems, this result agrees with recent experiments on microbial populations subject to a fine-grained environment.
主要相關著作:
A. E. Allahverdyan*; C.-K. Hu, 2009, “Replicators in Fine-grained Environment: Adaptation and Polymorphism”, PHYSICAL REVIEW LETTERS, volume 102, p.058102. (SCI) (IF: 7.645; SCI ranking: 7.6%)
(3) 西元年:2008
研究人員(中):胡進錕、洪耀正
研究人員(英):HU, CHIN-KUN, Yao-Chen Hung
研究成果名稱(中):「瞬間轉換熵」與混沌通訊加密方法
研究成果名稱(英):Novel Method of Chaotic Communications with Potentially Wide-ranging Applications
簡要記述(中):本所「統計與計算物理實驗室」研究員胡進錕教授與物理研究所博士後研究學者洪耀正提出一個嶄新的「瞬間轉換熵」(Temporal Transfer Entropy)觀念,為傳統通訊傳遞方式頻遭破解的窘境,開創嶄新加密方法。這篇論文已於2008年12月12日發表在國際知名期刊《物理評論通訊》(Physical Review Letters) [1],由於此概念應用層面非常廣泛,可望受到國際學術界和產學界的高度重視。傳統的混沌加密方式,是將想要隱藏的資訊,加載於由混沌信號所構築的載波裡。藉由載波紊亂、無序的特性,第三者無從獲悉加密者所欲傳遞的訊息。然而隨著訊號析離技術的發展,這樣的方式已經漏洞百出。
針對這些問題,洪耀正博士和胡進錕教授提出一個新穎的解決之道,亦即利用混沌載波間的因果相關性(Causality)來編撰二元訊息。換句話說,訊息不再包含於混沌載波之中,而是載波與載波間具有方向性的瞬時相關性。為了讓接收者轉譯出訊息,他們基於訊息理論(Information Theory)引入了「瞬間轉換熵」(Temporal Transfer Entropy)的概念,以監控並量取因果相關性的瞬時變化。如此一來,外人眼中沓亂隱晦的數字陣列,卻同時也是知情者眼中意涵豐富的二元符號。
更令人鼓舞的是,這項「瞬間轉換熵」的分析工具,可進一步應用到其它不同領域,諸如醫學、經濟學、以及氣象學等學科。舉例來說,癲癇症患者在進行外科手術切除大腦局部前,必須明確地定位出癲癇發作區間以減少手術對病人腦部的傷害。藉由腦波訊號的紀錄以及即時因果相關性的分析,醫師將可準確掌握發作部位從而降低手術造成的損傷。而藉由此工具分析歷年來溫度變化、二氧化碳濃度變化等數據資料,也有助於釐清造成地球暖化現象的因果關係。

簡要記述(英):Two physicists from the Institute of Physics of Academia Sinica in Taipei, Dr. Yao-Chen Hung and Dr. Chin-Kun Hu, have developed a new method of “chaotic communication,” an application of Chaos Theory aimed at providing secure transmission of information through telecommunications technologies. Their research, published in Physical Review Letters, a leading international physics journal, on 12 December 2008, has potential applications in fields as wide-ranging as brain-surgery and climate change.

“In the bestseller ‘The Da Vinci Code,’ symbologist Robert Langdon is stunned to discover a trail of clues to a bizarre murder hidden in the works of Da Vinci – the clues visible for all to see, and yet ingeniously disguised by the painter,” said Dr. Hu, in an attempt to explain the complicated abstract physical concepts that surround his latest paper. “Physics, it seems, can mask its secrets in a similar manner!”

Traditionally, the basic idea underpinning chaotic communication has been to mask a weak message onto a strong chaotic carrier. Because of the randomness and disorderliness of the carrier, the intruder fails to uncover the transmitted message. However, since the development of time series analysis, says Hu, such a scheme has become a little antiquated. In the newly published paper, the two Taiwanese physicists have developed a counterintuitive scheme which hides binary messages in causal relationships between coupled chaotic systems. In other words, the message is no longer contained in the carrier, but in the instantaneous causality between carriers. At the receiver, the encrypted message is recovered by a measure termed, ‘temporal transfer entropy’ (TTE), a concept based on information theory. The scheme has been demonstrated to be robust against external noise and some traditional attacks.

Most interestingly, the proposed nonlinear measurement, TTE, can be applied to many different fields, such as neurophysiology, economics, and climatology. For example, successful brain surgery in patients with medically intractable epilepsy strongly depends on an accurate definition of the brain volume that evokes seizure; monitoring the causality of possible interactions within the epileptogenic network would be beneficial to locate the epileptic focus and then minimize surgery-induced neurological deficits. (See Matthaus Staniek and Klaus Lebnertz in a Physics Review Letters paper published, 18 April 2008). Moreover, the analysis of variations of temperature, concentration of greenhouse gases, and solar total irradiance, could be of great importance in identifying the exact origins causing global warming.

The paper entitled “Chaotic Communication via Temporal Transfer Entropy” was published in Physical Review Letters volume 101, 244102 on 12 December 2008.


主要相關著作:
Yao-Chen Hung,Chin-Kun Hu, 2008, “Chaotic Communication via Temporal Transfer Entropy ”, PHYSICAL REVIEW LETTERS, 101 , 244102. (SCI) (IF: 7.645; SCI ranking: 7.6%)
(4) 西元年:2007
研究人員(中):胡進錕
研究人員(英):HU, CHIN-KUN
研究成果名稱(中):電腦模擬蛋白質的的展開與再摺疊
研究成果名稱(英):Computer Simulations of Protein Unfolding and Refolding
簡要記述(中):美國哥倫比亞大學Julio M. Fernandez 和 Hongbin Li以原子力顯微鏡研究泛素(ubiquitin)的重新摺疊過程。他們將泛素用原子力顯微鏡拉開,再將拉力降至某一值fq,然後觀察泛素重新摺疊。他們發現重新摺疊的過程與起始條件有關,摺疊所需的時間tF的指數與fq成正比[Science 303,1674(2004)]。中央研究院物理所胡進錕與合作者用鄉信廣模型(Go model)及分子動力學模擬法研究免疫球蛋白氨基酸系列I27用力拉開,再將拉力降至fq的重新摺疊過程,他們也發現重新摺疊的過程與起始條件有關,且摺疊所需的時間tF的指數與fq成正比。此研究成果發表於「美國科學院論文集 [Proc. Natl. Acad. Sci. U.S.A. 103, 93-98 (2006)]」。有關泛素的模擬結果則刊於2007年生物物理期刊 [Biophysical Journal 91, 547-561(2007). ]

簡要記述(英):Mechanical folding trajectories for polyproteins starting from initially stretched conformations generated by single-molecule atomic force microscopy experiments [Fernandez, J.M. & Li, H. (2004) Science 303, 1674-1678] show that refolding, monitored by the end-to-end distance R, occurs in distinct multiple stages. To clarify the molecular nature of folding starting from stretched conformations, we have probed the folding dynamics, upon force quench, for the single 127 domain from the muscle protein titin by using a Cα-Go model. Upon temperature quench, collapse and folding of 127 are synchronous. In contrast, refolding from stretched initial structures not only increases the folding and collapse time scales but also decouples the two kinetic processes. The increase in the folding times is associated primarily with the stretched state to compact random coil transition. Surprisingly, force quench does not alter the nature of the refolding kinetics, but merely increases the height of the free-energy folding barrier. Force quench refolding times scale as tF~t0Fexp(fq∆xf/kBT), where xf~0.6 nm is the location of the average transition state along the reaction coordinate given by end-to-end distance. [Mai Suan Li, Chin-Kun Hu, Dmitri K. Klimov, and D. Thirumalai, Proc. Natl. Acad. Sci. U.S.A. 103, 93-98 (2006)]. Similar results for unfolding and refolding of ubiquitin was published by M. S. Li, M. Kouza, and C.-K. Hu at [Biophysical Journal, 91, 547 (2007)].

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